This third edition retains the basic scientific principles associated with the previous editions but brings to light the latest challenges associated with preparing, characterizing, formulating and delivering the ever-increasing types of biopharmaceutical molecules into therapeutics. New chapters include biopharmaceutical structure and drug delivery, protein design and engineering, quality by design for biopharmaceuticals, manufacturing and purification of biopharmaceuticals, immune response triggers by route of administration, proteins in the solid state, the challenge of biosimilars, and transdermal delivery of protein therapeutics.