"Тройная угроза современных ядов - их глобальное распространение, огромное разнообразие и длительное неявное воздействие с отсроченными последствиями - сильно усложняет ситуацию в сфере токсикологических исследований. Поэтому нет ничего удивительного в том, что природа объектов исследований современной токсикологии не всегда ясна не только неспециалистам или студентам, но и серьезным ученым. Зачастую возникает неверное понимание метаболического пути, транспорта, абсорбции, выделения и биологической активности токсичных веществ. Сложность понимания токсикологии, в силу описанных выше причин, стала поводом к написанию этой книги. Моя цель - внести немного ясности в существующий хаос и представить современные достижения в этой сфере таким образом, чтобы они были понятны непрофессионалу." Алан Колок
О чем книга
Если в Средние века отравляющие вещества, природные и синтетические, применялись точечно, то в наше время они производятся и используются в промышленных масштабах. Сегодня химикаты или их следы можно обнаружить почти везде. Мы потребляем их с пищей, наносим на кожу и волосы. Наша одежда, дома, машины, любимые гаджеты - все это создается с "участием" опасной для здоровья химии. Вы узнаете из книги о том, что происходит в мире токсикологии сейчас, как и для чего ученые разрабатывают всё новые смертоносные яды, под какими красивыми масками они нам преподносятся, как проникают в наш организм и какие последствия вызывают, и, конечно, о тех маленьких бездумных преступлениях против окружающей среды, которые мы ежедневно совершаем не задумываясь.
Почему книга достойна прочтения
автор очень увлекательно рассказывает о природных и созданных человеком ядах, об их разновидностях, действии и последствиях, о том, как и зачем люди поставили производство отравляющих веществ на поток, и к чему это привело в наши дни; вы узнаете много нового о воздействии на ваш организм современных токсических веществ: как и в какой момент они становятся отравляющими (те же тяжелые металлы, например), что именно происходит с вашими органами и тканями при контакте с явными и неявными ядами, как они влияют на наши здоровье и наследственность, как яды выводятся из организма; воздействие создаваемых и применяемых нами токсических веществ на окружающую среду считается неудобной темой. Алан Колок вытаскивает на поверхность нелицеприятные факты вроде использования ДДТ во время Второй мировой войны или гибели птиц от диклофенака ("Вольтарен"), широко применяемого в ветеринарии, о воздействии флуоксетина ("Прозак") на рыб, а пестицидов - на крыс. Однако и мы сами все чаще употребляем в пищу отравленные нами же мясо, рыбу, овощи - автор призывает задуматься, насколько это безвредно для нас, и сделать выводы. Для кого эта книга
Для широкого круга читателей, особенно для тех, кто интересуется вопросами токсикологии, экологии, генетики, влияния отравляющих веществ на человека.
The book covers the basics of toxicology and like the title said it's brief but gives a good idea of the berth of things that can fall under toxicology and the ways in which a lot of toxins work. I really enjoyed this one, I learned a lot I didn't know but there was a good amount of stuff that I did know which was good because I think without a little background this book wouldn't make as much sense. I had no clue that poisons can become more and more concentrated as you go up the food chain. Also the whole thing with prions was pretty cool though like he said I'm not sure they fall under toxicology. It's a really good primer for someone who wants to know more about toxicology and going in with some idea of chemistry or biology might be best otherwise it can be annoying to keep up. The book is really general and wide in scope though and not really rigidly organized so I wouldn't use it for studying or anything, I think it's better for someone looking to learn more about the field and who wants some general knowledge or increase their knowledge of biochemistry.
In 2019, the US Environmental Protection Agency (EPA) revealed that only 47 percent or 40,655 of the 86,228 chemicals in its toxic substances inventory are being currently used in commerce. This is the first major update the agency has done in 40 years, allowing it to focus its attention on chemicals actually in use. It is astonishing that over 40,000 industrial toxic substances are being used in the US, but perhaps more surprising is the acknowledgement by the EPA that this list of toxic substances does not include pesticides, drugs, cosmetics, etc. And this is despite pharmaceuticals and personal care products being identified by the EPA as contaminants of emerging concern due to the possibility of endocrine disruption and low acute toxicity. The EPA simply does not have the resources to review every possible substance for safety. For example, with the passage of the Food Quality Protection Act of 1996, the EPA was tasked with reassessing almost ten thousand pesticide tolerances and reviewing them all again every fifteen years. This is just the tip of the iceberg of the responsibility the EPA has in trying to protect humans and the environment from the potential negative effects of human activities.
We currently live in a “chemical soup” of our own creation that has spread around the world, subjecting humans, animals, and plants to unknown adverse effects. Many new chemicals and potential contaminants are being developed and used with little or no research or controls over their impact on human health and the environment. Who actually knows what all these artificial compounds are doing to us and the environment? No one knows all of consequences, but toxicologists can help us as they attempt to make sense out of the chaos. Lexico defines toxicology as “the branch of science concerned with the nature, effects, and detection of poisons.”
Well aware of the global spread, massive diversity, and complications from chemical contaminants, Alan Kolok seeks to shed some light on the field of modern toxicology by presenting a general overview to those new to the subject with his book Modern Poisons: A Brief Introduction to Contemporary Toxicology. He believes that his book may also benefit scientists by highlighting important points that are not always apparent, even to toxicologists. Alan Kolok is Professor and Director of the Idaho Water Resources Research Institute, Director of the Center for Environmental Health and Toxicology at the University of Nebraska Medical Center, and an Editor of the journal Environmental Toxicology and Chemistry.
The first several chapters of the book take the reader on a journey through the fundamentals of chemistry and biology, describing the chemical makeup of toxins and how this affects their ability to be absorbed by the body. Kolok illuminates the various organs and bodily defenses down to the cellular level, showing how the body can manage toxins but is also vulnerable depending on the substance or situation. The rest of the book focuses on a variety of topics, including the negative effects of specific toxins, the history of regulation, and the transgenerational effects of exposure.
To those not familiar with the impetus for regulating food and drugs, Kolok recounts the pre-regulation “wild west” where everyone had to look out for themselves amongst the onslaught of bogus claims, which led to an array of laws to centralize evaluation for improved safety. By the end of the book, it is clear why toxic substances should be taken seriously by everyone. This is emphasized in the chapter on transgenerational toxicology, where it is shown how a mother’s exposure can not only harm her children but possibly her grandchildren as well.
After reading Kolok’s book you will realize that there is no such thing as pristine when it comes to the environment. Earth is no longer “natural” and human disturbances are pervasive. Kolok explains how no microbe, plant, or animal is safe as pollutants move around the globe through the air, land, and water following the path of earth’s geochemical cycles. A specific example in the chapter on persistent organic pollutants shows how DDT can travel by vaporizing, entering the atmosphere, and condensing to return to earth. More concerning for the future is climate change, which Kolok declares to be a “toxic enabler.”
Kolok achieves his goal of stimulating the reader’s curiosity in chemicals and their effect on our health. His book superbly describes complex topics in toxicology with plain language and bite-sized sections that allow the reader to understand his essential points and connect the science to the challenges of the past, present, and future. If you have any interest in toxicology, I would highly recommend this book.
When I was nearing the end of a course in environmental toxicology in my graduate program, I felt a bit overwhelmed at the complexity of toxicology. My textbook was over 600 pages and only covered the basics on a great deal of topics within environmental toxicology, and many parts of the textbook were not definitive regarding the effects of contaminants on organisms or ecosystems because the science is still emerging. Reading Kolok’s book reassured me a little by realizing we have experts who are able to navigate through the vast and intricate field of toxicology, and who are able to communicate the complex science into simple messages for non-experts while acknowledging there is much left to be discovered.
References US Environmental Protection Agency (2019, February). EPA Releases First Major Update to Chemicals List in 40 Years. https://www.epa.gov/newsreleases/epa-...
US Environmental Protection Agency (n.d.). Contaminants of Emerging Concern including Pharmaceuticals and Personal Care Products. https://www.epa.gov/wqc/contaminants-...
"Modern Poisons" explains the basic principles of toxicology for the average person. The tone was generally formal, and the beginning chapters were technical enough that it's helpful if you've taken at least a high school chemistry or biology class. He clearly explained any technical language, and I don't think most people would find the text confusing though you do need to pay attention. I would highly recommend this book to everyone as it's an important topic to understand.
The author began with information on how our body deals with toxins, how things are tested for toxicity, and how things have changed in testing as concerns have grown from determining lethal doses to include adverse affects at lower doses and toxins that aren't broken down. He discussed both natural toxins (like harmful metals and snake venom) and synthetic chemicals. I really liked the information on how our body absorbs chemicals through our skin, lungs, and digestive tract and how our body protects us from toxins. I feel like I can better sort out popular health claims now.
The author also talked about toxins in the air, water, land, and animals and how toxins are broken down (through biotransformation) or aren't (and so accumulate in animals higher up the food chain). He discussed drugs, pesticides, cosmetics, and food additives. He talked about historical issues (like DDT), newer concerns (like prions, persistent organic pollutants, multi-generational impacts, and antibacterial and pesticide resistance), and the social impact and regulation resulting from these concerns.
I received an ebook review copy of this book from the publisher through NetGalley.
This was an excellent and very educational read! As a long time studier (on an amateur level) of toxicology, this book approaches the subject on both an approachable to new student level and a long time student of the subject. This new take on a more modern look was very enlightening as well!
In 2019, the US Environmental Protection Agency (EPA) revealed that only 47 percent or 40,655 of the 86,228 chemicals in its toxic substances inventory are being currently used in commerce. This is the first major update the agency has done in 40 years, allowing it to focus its attention on chemicals actually in use. It is astonishing that over 40,000 industrial toxic substances are being used in the US, but perhaps more surprising is the acknowledgement by the EPA that this list of toxic substances does not include pesticides, drugs, cosmetics, etc. And this is despite pharmaceuticals and personal care products being identified by the EPA as contaminants of emerging concern due to the possibility of endocrine disruption and low acute toxicity. The EPA simply does not have the resources to review every possible substance for safety. For example, with the passage of the Food Quality Protection Act of 1996, the EPA was tasked with reassessing almost ten thousand pesticide tolerances and reviewing them all again every fifteen years. This is just the tip of the iceberg of the responsibility the EPA has in trying to protect humans and the environment from the potential negative effects of human activities.
We currently live in a “chemical soup” of our own creation that has spread around the world, subjecting humans, animals, and plants to unknown adverse effects. Many new chemicals and potential contaminants are being developed and used with little or no research or controls over their impact on human health and the environment. Who actually knows what all these artificial compounds are doing to us and the environment? No one knows all of consequences, but toxicologists can help us as they attempt to make sense out of the chaos. Lexico defines toxicology as “the branch of science concerned with the nature, effects, and detection of poisons.”
Well aware of the global spread, massive diversity, and complications from chemical contaminants, Alan Kolok seeks to shed some light on the field of modern toxicology by presenting a general overview to those new to the subject with his book Modern Poisons: A Brief Introduction to Contemporary Toxicology. He believes that his book may also benefit scientists by highlighting important points that are not always apparent, even to toxicologists. Alan Kolok is Professor and Director of the Idaho Water Resources Research Institute, Director of the Center for Environmental Health and Toxicology at the University of Nebraska Medical Center, and an Editor of the journal Environmental Toxicology and Chemistry.
The first several chapters of the book take the reader on a journey through the fundamentals of chemistry and biology, describing the chemical makeup of toxins and how this affects their ability to be absorbed by the body. Kolok illuminates the various organs and bodily defenses down to the cellular level, showing how the body can manage toxins but is also vulnerable depending on the substance or situation. The rest of the book focuses on a variety of topics, including the negative effects of specific toxins, the history of regulation, and the transgenerational effects of exposure.
To those not familiar with the impetus for regulating food and drugs, Kolok recounts the pre-regulation “wild west” where everyone had to look out for themselves amongst the onslaught of bogus claims, which led to an array of laws to centralize evaluation for improved safety. By the end of the book, it is clear why toxic substances should be taken seriously by everyone. This is emphasized in the chapter on transgenerational toxicology, where it is shown how a mother’s exposure can not only harm her children but possibly her grandchildren as well.
After reading Kolok’s book you will realize that there is no such thing as pristine when it comes to the environment. Earth is no longer “natural” and human disturbances are pervasive. Kolok explains how no microbe, plant, or animal is safe as pollutants move around the globe through the air, land, and water following the path of earth’s geochemical cycles. A specific example in the chapter on persistent organic pollutants shows how DDT can travel by vaporizing, entering the atmosphere, and condensing to return to earth. More concerning for the future is climate change, which Kolok declares to be a “toxic enabler.”
Kolok achieves his goal of stimulating the reader’s curiosity in chemicals and their effect on our health. His book superbly describes complex topics in toxicology with plain language and bite-sized sections that allow the reader to understand his essential points and connect the science to the challenges of the past, present, and future. If you have any interest in toxicology, I would highly recommend this book.
When I was nearing the end of a course in environmental toxicology in my graduate program, I felt a bit overwhelmed at the complexity of toxicology. My textbook was over 600 pages and only covered the basics on a great deal of topics within environmental toxicology, and many parts of the textbook were not definitive regarding the effects of contaminants on organisms or ecosystems because the science is still emerging. Reading Kolok’s book reassured me a little by realizing we have experts who are able to navigate through the vast and intricate field of toxicology, and who are able to communicate the complex science into simple messages for non-experts while acknowledging there is much left to be discovered.
References US Environmental Protection Agency (2019, February). EPA Releases First Major Update to Chemicals List in 40 Years. https://www.epa.gov/newsreleases/epa-...
US Environmental Protection Agency (n.d.). Contaminants of Emerging Concern including Pharmaceuticals and Personal Care Products. https://www.epa.gov/wqc/contaminants-...
После недавнего отравления каэндээровскими спецслужбами Ким Чен Нама руки сами тянутся к подобным книгам. Увы, в этой рассказа о боевых ядах типа VX, которым, судя по всему, «окропили» корейца, нет. Однако других парадоксальных смертей, за которыми стоят неожиданные вещества, предостаточно.
Даже яды в трупах могут доставлять неудобства — противовоспалительный диклофенак, которым пичкали коров в Индии, накопившись в их печени, убивал падальщиков-грифов, подчищавших туши (сами индусы их не едят). Скоро птиц осталось так мало, что сектам, веками оставлявшим своих мертвых на утилизацию грифам, пришлось отринуть заветы предков.
По сравнению с этим «кошачьи десанты» на Борнео, куда самолетами доставляли новых кошек взамен убитой ДДТ местной популяции, выглядят просто милым анекдотом. Обладающие свободой воли люди могут травиться и намеренно: посмотрите на злоупотреблявших... серебром. Аргироз — и вас точно заметят.
Хотя книга заявлена как науч-поп, она намного более сложная чем прочитанные в обозримом прошлом "Очаровательный кишечник" и "Теория всего". Уровень сложности изложения в ней на мой неискушенный взгляд очень высокий. Не сложилось впечатления что автор что-то упрощал или огрублял для неофита. Самая интересная часть для меня оказалась в эпизодах взаимодействия между экологами или фармацевтами с государством за право на чистый воздух, воду и так далее. Очень интересные истории про экологические последствия применения новых химикатов, про лекарства с жуткими осложнениями. Что хочется вынести из нон-фикшн? Какие-то новые знания и понимание процесса, когда ты деталей уже не вспомнишь, но общее представление будешь иметь. На мой вкус в книге перебор с научной терминологией и недобор с реальными историями.
this book is a wonderful intro to toxicology. The wording is very science heavy, but it’s simple enough that one can understand it. This book might be challenging if your native language isn’t english.
It talks about a wide array of topics such as toxins effect on the environment and animals generations later.
Don't get the name of the book wrong: it is not about poisons and toxicology but about pollution impact on ecosystems. The book has some short introduction to toxicology, but nothing more specific than a typical school level.
This book provides a great summary of the field of toxicology and the threats of low dose chronic poisoning people face today. I was assigned this book as in class reading for a college course but read it for pleasure after the class was actually over.
“Modern Poisons” is informative and easy to understand for the layman. As an author, I found it invaluable in doing research for my newest murder mystery, "Plan to Kill."
Toxicology brought to you in a simple, educational but thoroughly manner. A very enjoyable and informative read. Everyone should read this book, which is scientific literature made accessible, in order to make responsible choices in our everyday lives concerning use of medication, toiletries, gardening products, etc. Because toxicology is no longer confined in highly secured laboratories but is everywhere around us: in the air we breathe and the water we drink.
A nice introduction to the subject for a lightly-educated layman (familiarity with the general terminology of science and its language being the only real requirement), this is an informative text, and, dare I say, inspirational. :)
From snake bites to epigenetics, the field of toxicology is integral to understanding and improving public health and environmental science. Toxicology is the study of how chemicals affect living organisms, and lives at the intersection of chemistry and biology. If that scares you, do not fear. Dr. Kolok explanations of basic chemistry and biology are extremely accessible. Interspersed between the abstract scientific principles are fantastic real-world examples that bring the topics to immediate relevance. Some of my favorites include —
Napoleon always thought he would be poisoned by the English, and arsenic in sequestered in his hair seemed to validate his theory. But as it turns out, his green bathroom wallpaper did him in. Sheele’s green (copper arsenite) is converted to trimethylarsine gas by molds. All chemical compounds can be divided into two categories: water soluble or not. Compounds that do not dissolve in water are called lipophilic, and this trait determines what crosses the blood-brain barrier. Lipophilic drugs like alcohol, caffeine, nicotine, heroin, methamphetamine, and cocaine travel through the blood stream and enter the brain quickly and efficiently. Most pharmaceutical drugs are water-soluble, and pose a challenge to therapeutic drug delivery. The body has some defenses against lipophic drugs, including biotransformation. Unfortunately, in the case of acetominophen, the body converts the Tylenol active ingredient into a highly toxic metabolite for a short time before converted again into the excretable form. However, the second conversion sometimes fails or slows, as in a Tylenol overdose or in the case of Tylenol combined with alcohol. During the 1700s, boys employed as chimney sweeps on bathed a couple of times a year, despite being covered in sweat and soot, which would collect in their groin, developing into “soot-wart” and testicular cancer. This example is famously known as the first occupational hazard. Modern Poisons is not meant to replace a toxicology textbook, but provides the groundwork necessary for the average person to understand current agency standards for chemical limits, including organochlorine pesticides that bio-concentrate up the food chain, the saccharine in your diet cola, or the personal care products (PCPPs) that are affecting the sex morphology of wildlife.
Recommended as an introduction and survey to modern applicable toxicology!
Thanks to Netgalley and and Island Press for a free copy in exchange for an honest review!