Long Non-coding RNA: The Dark Side of the Genome

by Antonin Morillon

The dark side of the genome represents vast domains of the genome that are not encoding for proteins – the basic bricks of cellular structure and metabolism. Up to 98% of the human genome is non-coding and produces so-called long non-coding RNA. Some of these non-coding RNA play fundamental roles in cellular identity, cell development and cancer progression. They are now widely studied in many organisms to understand their function. This book reviews this expanding field of research and present the broad functional diversities of those molecules and their putative fundamental and therapeutic roles and develops the recent history of non-coding RNA, their very much debated classification and how they raise a formidable interest for developmental and tumorigenesis biology. Using classical examples and an extensive bibliography, the book illustrates the most studied and attractive examples of these long non-coding RNA, how they interface with epigenetics, genome integrity and expression and what are the current models of their regulatory mechanisms.

190 pages, Hardcover

Published January 31, 2018

Reviews

[Mike Lisanke · Rating 2 out of 5]

This is Not light reading... it's filled with jargon which is assumed understood by the reader. In general, I'd say this book will only benefit those in ancillary fields of genetics/epigenetic study. I have studied biochemistry and some biotechnology and understand the basics of genetics/epigenetics but this book is not much of an explanation of the deeper nature of non-coding RNA and does little story telling to acquaint the reader with the topic (IMO).

[Rafał Grochala · Rating 4 out of 5]

Nice overview of 'a veritable terra incognita'. Short, but deep (fifty pages of bibliography FTW). Worth checking out on a cold winter evening.