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The Alzheimer's Solution: A Revolutionary Approach to Prevent and Reverse Alzheimer's, Offering Hope Through Groundbreaking Science and Personalized Treatment Plans

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A revolutionary, proven program for reversing the symptoms of Alzheimer's disease and cognitive decline from award winning neurologists and codirectors of the Brain Health and Alzheimer's Prevention Program at Loma Linda University Medical Center Over 47 million people are currently living with Alzheimer’s disease worldwide. While all other major diseases are in decline, deaths from Alzheimer’s have increased radically. What you or your loved ones don’t yet know is that 90 percent of Alzheimer’s cases can be prevented. Based on the largest clinical and observational study to date, neurologists and codirectors of the Brain Health and Alzheimer’s Prevention Program at Loma Linda University Medical Center, Drs. Dean and Ayesha Sherzai, offer in The Alzheimer’s Solution the first comprehensive program for preventing Alzheimer’s disease and improving cognitive function. Alzheimer’s disease isn’t a genetic inevitability, and a diagnosis does not need to come with a death sentence. Ninety percent of grandparents, parents, husbands, and wives can be spared. Ninety percent of us can avoid ever getting Alzheimer’s, and for the 10 percent with strong genetic risk for cognitive decline, the disease can be delayed by ten to fifteen years. This isn’t an estimate or wishful thinking; it’s a percentage based on rigorous science and the remarkable results the Sherzais have seen firsthand in their clinic. This much-needed revolutionary book reveals how the brain is a living universe, directly influenced by nutrition, exercise, stress, sleep, and engagement. In other what you feed it, how you treat it, when you challenge it, and the ways in which you allow it to rest. These factors are the pillars of the groundbreaking program you’ll find in these pages, which features a personalized assessment for evaluating risk, a five-part program for prevention and symptom-reversal, and day-by-day guides for optimizing cognitive function. You can prevent Alzheimer’s disease from affecting you, your family, friends, and loved ones. Even with a diagnosis, you can reverse cognitive decline and add vibrant years to your life. The future of your brain is finally within your control.  

368 pages, Paperback

Published January 29, 2019

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1567 people want to read

About the author

Dean Sherzai

19 books21 followers
Dean Sherzai, MD, PhD, is Co-Director of the Alzheimer's Prevention Program at Loma Linda University Health, where he was previously the Director of the Memory and Aging Center as well as Director of Research. During his years at Loma Linda, a Blue Zone community where residents live measurably longer and healthier lives, he was the lead scientist studying the effects of healthy living on cognitive aging. Dean trained in Neurology at Georgetown University School of Medicine and completed fellowships in neurodegenerative disease and dementia at the National Institutes of Health and UC-San Diego, where he studied under Dr. Leon Thal, one of the world’s most renowned dementia researchers, and Dr. Dilip Jeste, the world’s foremost specialist in cognitive aging. He also holds a PhD in Healthcare Leadership with a focus on community health, and a Masters in Public Health from Loma Linda University, where his research focused on the prevention of cognitive decline through lifestyle changes. Dean has won several awards and published numerous scientific papers, including comprehensive reviews on nutrition and neurodegenerative disease and a recent meta-analysis of cognitive training and memory improvement.

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Displaying 1 - 30 of 109 reviews
Profile Image for Cheri.
2,041 reviews2,979 followers
September 18, 2018
They'd never spent a night apart,
For sixty years, she heard him snore.
Now they're in a hospital,
In separate beds on different floors.

Claire soon lost her memory,
Forgot the names of family.
She never spoke a word again,
Then one day, they wheeled him in.

He held her hand and stroked her hair,
In a fragile voice she said:
"Where've you been? "
"I've looked for you forever and a day."
"Where've you been?"
"I'm just not myself when you're away."
"No, I'm just not myself when you're away."

-- Where’ve You Been,Kathy Mattea, Songwriters: Don Henry, Joe Vezner

RADICALLY REDUCES RISK OF ALZHEIMER’S DISEASE BY 90%

A Breakthrough Program to PREVENT AND REVERSE THE SYMPTOMS OF COGNITIVE DECLINE at Every Age

Section One of this book is devoted to “The Truth About Alzheimer’s,” the Myths and Misunderstandings, and the Power of Lifestyle Medicine

”In 2016, Alzheimer’s disease was the sixth-leading cause of death in the United States. Some researchers believe that Alzheimer’s is grossly underreported on death certificates. Oftentimes the official cause of death for a person with Alzheimer’s is a dementia-related condition like aspiration pneumonia. This means that Alzheimer’s may in fact be America’s third-most deadly disease, behind only heart disease and cancer.”

”In 2015, the World Health Organization estimated that the total number of people with Alzheimer’s worldwide will rise to 135.5 million by 2050. By then, global costs will surpass twenty trillion dollars. This figure doesn’t take into account the vast amount of unpaid caregiver hours. In 2015 alone, caregivers provided an estimated eighteen billion hours of unpaid care. The demands of this disease could crash not only our health-care system, but our entire financial system.”

”Spouses of Alzheimer’s patients are 600 percent more likely to develop the disease themselves.”

If you think this doesn’t concern you because you don’t know anyone who has had Alzheimer’s, or because none of your family has had Alzheimer’s, then you might want to consider that this will impact you one way or another.

Section Two focuses on The NEURO Plan
According to these doctors, though, there is hope. They estimate that 90 percent of Alzheimer’s cases can be prevented through:
N – Nutrition
E – Exercise
U – Unwind
R – Restore
O – Optimize

This book is not about a cure, as much as it is about reversing the debilitating symptoms, or showing you how even small changes can possibly prevent or slow down the progression. One could assume that the earlier you begin changing your diet, your lifestyle, the lower your chances of being affected by this disease are.

In 1993, a Loma Linda University study of over 3,000 subjects found that the risk of developing dementia for those who eat meat was twice that of vegetarians. This study led to their focus on the lifestyle of the local population of Seventh Day Adventists, whose diet is primarily a plant-based diet, who are largely responsible for Loma Linda being a “Blue Zone,” a designated longevity spot. There is a McDonald’s in Loma Linda, but it serves veggie burgers. The Cafeteria at the University is vegetarian.

While this wasn’t a “fun, entertaining” read, it was more engaging the further I read, while the focus is on dementia, the statistics for this diet lower the rate of cancer, as well as other life altering or ending diseases.

The third section is: Recipes

Altogether, there are probably around 40 recipes that sound delicious, and have the extra benefit of actually being healthy. I can’t wait to try some of these recipes!


Many thanks to the Public Library system, and the many Librarians that manage, organize and keep it running, for the loan of this book!
Profile Image for Christopher Lawson.
Author 10 books131 followers
August 18, 2017
We Know The Current Approach Isn’t Working. We Don’t Have Time To Lose.

In THE ALZHEIMERS SOLUTION, doctors Dean and Ayesha Sherzai give us the bad news first: “There is reason to be afraid” they announce. Deaths due to Alzheimer’s have “increased by nearly 87 percent in the last decade.” The disease is also incredibly expensive, costing $226 billion in the United States alone.

The early chapters of the book present the biology of the disease, including a discussion of how the brain is affected, and what type of external influences can prevent the damage. The good news (and surprising, to me) is that there is a LOT that we can do. “Ninety percent of us can avoid ever getting Alzheimer’s.”

Before reading this book, I wanted to know the qualifications of the authors. (I suspected they were not true medical doctors.) I stand corrected. The two are leading researchers in the field of Alzheimer’s, and have been associated with Cedars Sinai of Los Angeles—a world class institution.

A key to this book is the question of HOW did the doctors conclude that lifestyle could so dramatically reduce the odds of getting Alzheimer’s? How did they see things that other doctors did not?

The answer is, the authors were in a special place. They were doctors at Loma Linda University, where they were able to study two radically different groups. Their patients from Loma Linda—the “healthy group,” were mainly Seventh-day Adventists, who had drastically different diets, exercised regularly, and had good social ties. They were “some of the healthiest people in the world.” In contrast, the second group was patients in San Bernardino, an “underserved area plagued by chronic disease.”

After years of working and studying both groups, the doctors found that “People living a healthy lifestyle had a much lower prevalence of dementia. “ The Adventist population, on average, lived 10 years longer than others. The same lifestyle that promoted a healthy heart and kidneys “also appeared to be beneficial for the brain. They formed these conclusions:

• Eating meat is bad for your brain.
• Physical exercise increases both the number of brain cells and the connections between them.
• Chronic stress puts the brain in a state of high inflammation, causing structural damage.
• Restorative sleep is essential for cognitive and overall health.
• Higher education and other complex cognitive activities protect your brain against decline.
• Social support has an undeniable influence on the way your brain ages.

The authors developed a plan to promote the necessary lifestyle changes: NEURO.

Nutrition: A whole-food, plant-based diet low in sugar, salt, and processed foods.
Exercise: An active lifestyle that incorporates movement every hour.
Unwind: Stress management in the form of meditation, yoga, mindful breathing exercises.
Restore: Seven to eight hours of regular, detoxifying sleep .
Optimize: Multimodal activities that challenge many of the brain’s capacities

A big chapter is dedicated to each aspect. I was most interested in the Nutrition chapter. There, I found the “Top Twenty Brain-Nourishing Foods,” as well as the “Top Ten Foods to Avoid Processed Foods, and “10 Tips For Eating At Restaurants, And “Best Brain-Healthy Snacks.”

The “Optimize” chapter was also informative. I had always thought that doing puzzles was one of the best mind exercises; however, the doctors have some better suggestions. They suggest activities that use a broader part of your brain, to “engage multiple cognitive domains at the same time.”

The section on sleep had numerous suggestions, and this warning: “Chronic poor sleep and lack of sleep both cause significant damage to the brain.” The authors include a concise, “Techniques For A Better Night’s Sleep,” with tips like these:
1. Normalize Your Sleep Schedule:
2. Avoid Eating Late at Night:
3. Avoid Certain Drinks Too Close to Bedtime:
4. Avoid Exercising Before Sleep, But Be Sure to Exercise Earlier in the Day:
5. Low Light at Night, Bright Light During the Day:
6. Avoid Playing Games, Watching Stimulating Movies, and Working on your iPad in Bed:

So all in all, I found THE ALZHEIMERS SOLUTION to be an encouraging, practical book. Furthermore, it is an IMPORTANT book. I was already familiar with some of the studies on diet and exercise, but I had no idea that lifestyle could so dramatically reduce the odds of getting this wretched disease.

Keep in mind that it is difficult to conclusively PROVE that one thing causes another. Just because 2 things are correlated, that does not prove that one causes the other. It’s a high bar to reach. Nevertheless, the authors make a convincing case for the suggested lifestyle changes. I am implementing many of the lifestyle changes listed in this book, and am also encouraging my spouse to do the same. To see where you might benefit, there is an easy-to-do “Alzheimer’s Solution Risk Assessment” that identifies areas for possible lifestyle change.


Advance Review Copy courtesy of the publisher.
Profile Image for Esther .
966 reviews197 followers
June 30, 2017
This was informative and educating.

Overview of Alzheimers and how lifestyle (nutrition, exercise, relationships, sleep, etc) are what can possibly prevent or deter the onset of Alzheimers. Even delay or stall the disease.

Helps breakdown the possible contributors to Alzheimer, as in possible family history and lifestyle in getting the disease.

Dedicates chapters to each of the keys for prevention. With in-depth explanations for why and how it contributes too or prevents the disease, as in eating certain foods that are bad verses foods that are healthy for the brain. Cases/Examples of patients and their recovery by changes their lifestyle.

This book gave hope, encouragement and tools needed against this disease. Found it informative and educating.

Not a five star as a bit too much medical jargon and overload of some terms.

Loved the recipes in the end.

Profile Image for Allysia K.
196 reviews77 followers
January 9, 2018
I find Alzheimer's fascinating and terrifying, so I really enjoyed this heady book. What I love about this is book is that it's very science-based with excellent information and research - but it's also very practical and actionable. It focuses on what you can do to lower your risk of Alzheimer's using a mnemonic device (NEURO).

NEURO stands for nutrition, exercise, unwind, rest and optimize. The book helps you identify your weak spots and gives you lots of great suggestions to improve.

Read this if you enjoy keeping up to date with medical literature and want to take preventative measures against Alzheimer's.
17 reviews1 follower
October 31, 2017
When an Author Gets It Right

In their book “The Alzheimer’s’ Solution,” Drs. Dean and Ayesha Sherzai propose an ambitious plan with a promising positive influence not only over your memory performance and prevention of dementia, but your overall health. The bullet points of their plan are already mentioned in some previous reviews, but what stood out for me, as a psychotherapist with background in medicine, are the following:

1. The Authors’ Holistic Approach: The authors, unlike many other professionals in their field, are fully aware - and proponent of – a holistic approach and its importance in treating (and most importantly, preventing) diseases, particularly dementia. They objectively highlight the problem of having a myopic approach to medical challenges, which is unfortunately rampant in the medical field, and which is often dismissive of prevention and behavioral change. This is critical because as long as our approach is myopic, and pathology/disease-oriented, we are looking for one-dimensional, simplistic solutions and ignore the role of lifestyle and multiple other factors that help ensure and maintain better health.

2. The Authors’ Objectivity: If you are already exposed to the field of self-help and happened to have read a few self-help books, you probably know that there is plethora of information on the market in the form of books, e-books, magazines, websites, blogs, etc. Alas majority of the information offered for readers sandwiched as self-help is purely subjective and lacking sufficient, objective material. This is because a significant number of self-help books follow a familiar narrative style of focusing on few cases of individuals who have overcome a life challenge, achieved success in another domain of their lives, etc. Such experiences are, to the most part, not replicable. Nevertheless, the Sherzais’ approach is objective, scientific, well-researched, and the Notes are particularly impressive, demonstrating the depth of their efforts in the subject matter and providing wealth of knowledge and resources for those who are interested to read more on the subject.

3. Not only theoretical, but also practical
The authors, who have done extensive research in addition to comprehensive meta-analysis of hundreds of studies on dementia, not only explain the theoretical and scientific mechanisms behind dementia (as much jargon-free as possible!), but they also offer workable strategies and practical solutions in the form of NEURO (Nutrition, Exercise, Unwind, Restore, and Optimize). The bullet points of the plan is already mentioned in other reviews, but it was a breath of fresh air to read the rationale behind their holistic plan, and much to the satisfaction of a scientific, objective mind, every step is supported by scientific data.

Last but not least, I immensely enjoyed reading the book, learned a few new things on memory performance and overall optimal physical/mental functioning and, of course, the significance of behavioral change in preventing chronic diseases.

And this simply means the authors got it right!
Profile Image for Andrea  *W*.
23 reviews2 followers
February 1, 2021
I've tried so hard to get through this book, but I just can't get through the nutrition recommendations. The brain needs cholesterol. They vilify animal products, but I don't see where the meat quality Is discussed or if the patient was currently exercising.

There's a study on a woman doing the paleo diet, but there's no mention if she's doing exercise or if she was eating carbs at all. They basically make fun of paleo books and use the famous line, "...lifespan was only 20 to 30 years", (p. 90) no mention of childbirth deaths, living exposed, etc. This is pseudo-hype.

I kept reading, but I eventually gave up after reading the horrors of saturated fat for the millionth time. They say on page 99 that butter will shrink the brain...no study mentioned. This reads like a book from the 90s.

If you're concerned about your mental health in any way, you need specific testing done for YOUR body. Most of the foods recommended in this book would make me cry in pain (beans, legumes, nuts, seeds, whole grains). Every body is different, but some things are necessary for mental health. I will fully disagree with the book and say saturated fat from animal products and cholesterol are required.

Please look for other Alzheimer's books, independent studies and have testing done.
2 reviews
November 4, 2019
Some good information

There were a lot good suggestions, however, the authors lose credibility with their adherence to the tired old 1980-90’s conventional wisdom and associational research that meat, eggs, saturated fat are evil. Those theories have pretty well been discredited by current research.
Profile Image for Bookfanatic.
280 reviews35 followers
December 18, 2017
There's a heavy emphasis on vegetarianism in this book which I don't find is supported by studies on Alzheimer's. Overall, it's an easy to read book with a plan of action for those who are looking for step by step guidance. Get it from a library so you don't have to spend money. There's really nothing revolutionary here for anyone who takes a moderate interest in personal health. Get enough sleep, find ways to reduce stress, have a good social network, eat a variety of vegetables and fruits preferably low-glycemic, keep your weight within normal limits, be physically active, keep your mind active and to me controversially, reduce meat intake even chicken consumption. I prefer the book the "End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline" by Dale Bredesen, M.D because it's more scientific in its approach and that author has better credentials in the field of neurodegenerative diseases.
Profile Image for Marie.
1,815 reviews16 followers
May 28, 2024
Protective factors for prevention of Alzheimer's are a plant based diet, daylight exposure, regular exercise, 7 to 8 hours of sleep, meditation, continual learning, purpose driven activities and social engagement.

Daily brisk walks resulted in a 40 percent lower risk of developing Alzheimer's later in life.

Working out at home is better. Exercise programs need to be easy and convenient.

Multi tasking is rapid task switching which places enormous stress on the brain. Multitasking takes an especially big toll on working memory in older adults.

Meditation is a wonderful addition to your bedtime routine. It relaxes the body by slowing both breathing and heart rate and has also been proven to reduce stress.
Profile Image for Linda.
374 reviews
December 30, 2017
If you read this book, you will become a Vegan! Sugar, meat, fish, dairy all are bad for your brain!
Profile Image for Ola.
42 reviews9 followers
December 15, 2018
This book is scary.
It makes it clear that unless you take responsibility for your lifestyle, not only your so-called physical health will be affected, but your cognitive capacity too.
105 reviews
November 15, 2017
I think everyone who is aging or has aging loved ones (that means everyone) should read this book. It is a totally different take on dementia than the one expressed by the medical community. If we take action to live healthier lifestyles, we can significantly reduce the chance and severity of dementia in our lives.
Profile Image for Elease.
484 reviews6 followers
February 1, 2024
This book didn't tell me much I didn't already know (eat vegetables! exercise! sleep! etc!), but it did gather all of these diffused pieces of advice for a healthy brain into one place. It also cleared out the noise if you want to focus on brain health (e.g., "More often than not, however, we meet people who've done their own research on nutrition and have made conscious decisions about what to eat every day... They think their diets are healthy, that they're making the right nutritional choices for their bodies, and yet they're still experiencing cognitive decline and other health issues" p. 83). There are copious studies cited and robust endnotes. There were some details here and there that I hadn't heard before and also many practical suggestions I found useful.

The Sherzais write in an engaging and readable way, acknowledging the difficulty of lifestyle changes and giving the reader tools and suggestions for how to make lasting changes. I recommend this book as a resource for anyone who wants to prioritize brain health (which is really whole-body health).
12 reviews
December 17, 2022
This book has great tips for preventing cognitive decline. I was on the no-sugar train for a good week after being reminded of the evils of sugar. I should probably keep listening to that chapter. Seriously, there are great tips and solid research in the book.
Profile Image for Octoberbear.
189 reviews
June 15, 2021
It falls into the typical trap for popular science/medicine books -- not presenting enough counter arguments, and not examining lurking variables in research. For example, this book advocates for studying a second language as one of the stimulating cognitive activities, and claimed that being bilingual is highly associated with preventing dementia later in life. But is there a neurological reason that bilingual brain really can protect itself from dementia longer? If the experiment is done through sampling, then most likely the lurking factor is socio-economical status being higher amongst bilingual population, thus bringing better life quality overall. We don't yet know the answer, but I was disappointed to see the author repetitively draws conclusions like this without even mentioning this obvious scientific fallacy.

Still 3 stars remaining because I think this book has values for people who survive on an obviously unhealthy lifestyle, and refuse to employ the proven benefit of diet, physical activities, and other things which are widely proven to be better for overall health. If "preventing Alzheimer" can finally be those people's motivation to change, so be it.
Profile Image for YHC.
857 reviews5 followers
October 22, 2025
from Grok
### 書籍重點精華

《The Alzheimer's Solution: A Revolutionary Approach to Prevent and Reverse Alzheimer's, Offering Hope Through Groundbreaking Science and Personalized Treatment Plans》(2017年由HarperOne出版,作者Dean Sherzai與Ayesha Sherzai)是一本基於科學的實用指南,挑戰阿茲海默症(Alzheimer's Disease, AD)無可避免的迷思。作者夫婦是神經科醫師與腦健康專家,提出「NEURO」計畫(Nutrition, Exercise, Unwind, Restore, Optimize),強調透過生活方式改變,可預防90%以上的阿茲海默症病例,甚至在早期逆轉認知衰退。該書結合臨床研究、病例數據與可行建議,主張大腦健康並非全由基因決定,而是可透過個人化策略主動管理。

全書分三大部分:
- **第一部:破解迷思**:解釋阿茲海默症的病理(β-澱粉樣蛋白、tau蛋白、神經炎症等),強調生活方式比遺傳影響更大(僅10-15%病例與基因高度相關)。
- **第二部:NEURO計畫**:詳細闡述五項生活方式干預(飲食、運動、減壓、睡眠、認知挑戰),提供科學證據與實操步驟。
- **第三部:應用與未來**:指導讀者打造個人化計畫,結合真實案例,展示如何長期維持腦健康,並呼籲社會政策支持預防。

核心論點是:阿茲海默症是一種「生活方式疾病」,像心臟病或糖尿病,透過改變飲食、運動、壓力管理和認知訓練,可大幅降低風險(研究顯示風險可減70-90%),甚至在輕度認知障礙(MCI)階段逆轉症狀。作者強調「預防即治療」,提供希望與行動藍圖。

以下是書籍精華要點,濃縮核心洞見:

1. **阿茲海默症可預防與逆轉**:90%病例與生活方式相關(飲食、運動不足、慢性壓力等)。研究顯示,MCI患者透過綜合干預(如地中海飲食+運動)可改善認知功能10-25%,部分早期患者恢復正常。基因(如APOE4)影響風險,但非決定性因素。

2. **NEURO計畫的五大支柱**:
- **Nutrition(飲食)**:採植物為主、富含抗氧化劑的地中海飲食(MIND飲食變體),減少加工食品、紅肉和糖,降低腦炎症與β-澱粉樣蛋白堆積(減少20-30%)。
- **Exercise(運動)**:每週150分鐘中強度有氧運動(如快走)+力量訓練,提升腦血流與BDNF(腦衍生神經滋養因子,增30%),促進神經新生。
- **Unwind(減壓)**:慢性壓力誘發皮質醇,損害海馬迴。冥想、正念或瑜伽可減壓力50%,改善記憶力。
- **Restore(睡眠)**:每晚7-8小時優質睡眠清除腦內毒素(如β-澱粉樣蛋白)。睡眠不足者AD風險增2倍。
- **Optimize(認知訓練)**:學習新技能(如語言、樂器)或社交活動,增強認知儲備(cognitive reserve),延緩症狀5-10年。

3. **個人化與整合策略**:每人風險因子不同(如糖尿病、肥胖、高血壓增加AD風險2-3倍)。NEURO計畫需依個人健康史、基因和生活習慣客製化,結合飲食日記、運動追蹤和認知測驗(如MoCA)監測進展。

4. **社會與政策影響**:作者批評醫療系統過分依賴藥物(如抗β-澱粉樣蛋白藥,效果有限且副作用多),呼籲推廣預防教育與社區計畫(如健康飲食補貼)。預防可節省全球醫療成本(AD治療2025年預估達1.2兆美元)。

這些要點強調:阿茲海默症不是宿命,簡單改變(如每日30分鐘快走+吃藍莓)就能顯著降低風險,效果媲美藥物但無副作用。

### 舉例(書中或相關應用實例)

書中結合真實病例與研究數據,生動說明NEURO計畫如何改變生活。以下是典型例子(部分來自書中,部分基於其原則延伸):

1. **飲食改變逆轉MCI(病例,Nutrition)**:書中描述一位62歲女性,診斷輕度認知障礙(MCI),記憶力下降。採用MIND飲食(每日藍莓、菠菜、堅果,減少紅肉與甜點),6個月後MoCA分數從22升至26(接近正常),細紋減少,精力提升。研究支持:富含Omega-3與抗氧化劑的飲食降低AD風險30%。現實應用:每天早餐加入1杯藍莓+亞麻籽,取代加工穀物。

2. **運動改善認知(病例,Exercise)**:一位55歲男性,有APOE4基因(AD高風險),無症狀但擔憂。他開始每週5次30分鐘快走+2次舉重,1年後腦霧減少,工作記憶力提升15%(認知測試驗證)。研究顯示:有氧運動增加海馬迴體積3-5%,抵禦神經退化。現實應用:用計步器設定每日8000步,���入公園慢跑。

3. **冥想減壓救記憶(病例,Unwind)**:書中提及一位高壓工作的48歲律師,常忘會議細節,壓力誘發皮質醇損害大腦。她每天10分鐘正念冥想(Mindfulness),3個月後壓力分數降40%,短期記憶改善10%。研究:冥想降低皮質醇,減少海馬迴萎縮。現實應用:下載Headspace App,每晚睡前冥想10分鐘。

4. **睡眠修復大腦(病例,Restore)**:一位65歲退休者,長期失眠,認知下降。遵循NEURO計畫,固定22:30睡覺、避免咖啡因,3個月後睡眠品質提升60%,β-澱粉樣蛋白清除效率增(腦脊液檢查)。研究:每晚少1小時睡眠,AD風險增20%。現實應用:關閉睡前1小時電子設備,保持臥室黑暗。

5. **學習語言增認知儲備(病例,Optimize)**:書中描述一位70歲女性,家族有AD病史,學習西班牙語並參加書友會,5年後認知測試無衰退跡象。研究:雙語者AD發病延遲4-5年,因認知儲備增強。現實應用:用Duolingo每天15分鐘學新語言,或加入社區志工活動。

這些例子展現NEURO計畫的實用性,從小改變(如吃堅果、散步)到結構化調整(睡眠規律),皆能顯著影響腦健康。書中強調:開始越早,效果越好;即使60+歲,仍可降低風險。

### 建議閱讀
若想深入,從「NEURO計畫」章節開始,作者用圖表與清單詳細說明如何實踐(如每日飲食清單、運動頻率)。若有家族病史或早期症狀,建議諮詢神經科醫師,結合MoCA測試與血液檢查(檢查炎症標記)。這些資訊基於書中科學與最新研究,個人效果因體質與執行力而異。
Profile Image for Carla Parreira .
2,063 reviews3 followers
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May 15, 2025
Melhores trechos: "...Constatamos, sistematicamente, que as pessoas que mantêm um estilo de vida saudável apresentam uma prevalência muito menor de demência. Em contrapartida, aquelas que mantêm estilos de vida pouco saudáveis apresentam demência com mais frequência, e, de modo geral, ela surge cedo. Observar todos os dias os notáveis efeitos da dieta, dos exercícios, do gerenciamento do estresse, da qualidade do sono e da atividade cognitiva alterou nossa perspectiva sobre a doença. A verdade era inegável: um estilo de vida saudável para o cérebro praticamente previne o Alzheimer... Consideremos indivíduos com síndrome de Down. Daqueles que estão na faixa etária entre 50 e 59 anos, um em cada três sofre da doença de Alzheimer. Cinquenta por cento dos acima de sessenta anos desenvolvem a doença. Esse aumento do risco da doença de Alzheimer está relacionado às causas da síndrome de Down. Indivíduos com síndrome de Down têm três cromossomos 21, e o código genético no cromossomo 21 produz PPA, uma proteína transmembrana responsável pela produção de amiloide, a proteína anormal associada à doença de Alzheimer... A pesquisa médica moderna é fundamentalmente equivocada quando se trata de curar uma doença crônica como o Alzheimer. Quase todas as nossas pesquisas estão baseadas em doenças, o que significa que os cientistas se concentram em desenvolver uma cura sob a forma de um medicamento único... Descobriu-se que as pessoas que seguiam uma dieta predominantemente vegetariana tinham uma expectativa de vida maior em quatro dos seis estudos. Em um grupo de mais de 3 mil indivíduos, aqueles que consumiam carne — incluindo quem ingeria apenas aves e peixes — tinham o dobro de risco de desenvolver demência, em comparação com os vegetarianos... Os parceiros daqueles que desenvolvem a demência têm um risco 600% maior de desenvolver a própria doença, em comparação com a população em geral, e isso não é atribuível apenas ao estresse. Os riscos do estilo de vida compartilhado são um fator importante nas consequências para a saúde de casais com uniões estáveis e duradouras... Se você não implementar práticas saudáveis ao seu estilo de vida, terá apenas 50% de chance de desenvolvê-lo algum dia. E, para a grande maioria, cerca de 90% de nós, adotar um estilo de vida saudável para o cérebro elimina esse risco por completo..."
1 review
December 2, 2017
This is my first book review on Goodreads; the book arrived as a giveaway and I was very pleasantly surprised to receive it. I am a new retiree, having worked several diverse careers.

The authors do a great job of providing hope for a very debilitating condition. Their research and breakdown of life components such as cognitive exercises, nutrition, stress control, physical exercise, and how to optimize the various factors that help preserve mental capacity as we age are all very well explained.

This book motivated me to go for a walk every day at quick pace and to alter my routes. It also motivated me to pull out the old guitar, buy new strings, and start playing and singing again. It seems that all the things we did as children that helped develop our brains get lost as we age. Activities like outdoor playtime, with friends, singing, dancing and learning new things.

The book has a lot of examples on how to reverse the early signs of cognitive decline. And how to prevent further deterioration. I usually pass along great books; this one I am keeping for awhile. Highly recommend.
6 reviews
October 7, 2022
My husband first experienced confusion and loss of memory in March of 2000 while undergoing rehab for alcoholism. Being home seemed to help him until 2006 when he gradually began experiencing Alzheimer’s symptoms. He had four to five hours a day where he wants to get a "greyhound" to "go home." Also, he thinks I am his sister and believes he has rented a car (he hasn't driven in five to 10 years). His personal hygiene was in the tank — it was necessary for him to change two to three times a day. Without long-term insurance for his care, it was becoming stressful to care from him. this year our family doctor introduced and started him on Healthherbsclinic Alzheimer’s Disease Herbal Tincture, 6 months into treatment he improved dramatically. At the end of the full treatment course, the disease is totally under control. No case of Alzheimer’s, hallucination, forgetfulness, and other he’s strong again and able to go about daily activities. visit their official website, www. healthherbsclinic. com
Profile Image for Clint.
1 review
May 2, 2020
This book will empower you to take charge of your health and make incremental lifestyle changes to significantly delay, prevent, or reverse early symptoms of this terrible disease. It will give you hope and inspiration. This is not a scary book.

Growing up, I was under the impression that if one had strong genetic risk factors for Alzheimer's disease, a diagnosis was inevitable and something beyond your control. The Alzheimer's Solution demonstrated to me that this impression is mostly false. This book bridges the knowledge gap between the medical community and the rest of society, demonstrating the importance of preventative lifestyle medicine. The education that this book provides is so important for everyone living in our modern society, young and old alike.

The book was well written and easy to understand. I enjoyed that reading the stories of case studies with real patients and also liked that they described how they incorporated the NUERO plan into their daily lives.
Profile Image for Shayla.
230 reviews1 follower
May 15, 2018
Researchers and neurologists Drs Dean and Ayesha Sherzai explore Alzheimer's through the current research, their own medical experiences and the evidence within their own community of Loma Linda, one of the Blue Zones. They include practical steps to maintain your cognitive health.
They incorporate nutrition - avoid processed foods, eat a plant-based diet, and exercise. As well as including mental challenges to avoid cognitive decline. An all-inclusive look at how our health habits can make a difference.
Their research reinforces the facts that our brain, heart and body are not separate entities, what affects one will affect the other.
Alzheimer's isn't a consequence of ageing but can be another chronic disease caused by lifestyle factors. A positive look at how to prevent the majority of cognitive decline.
Profile Image for William Schram.
2,427 reviews99 followers
August 20, 2018
In The Alzheimer’s Solution by Dean & Ayesha Sherzai, we find that Diet and Exercise is pretty much the most potent medicine we have. With their medically proven course of action, you can slow or reverse your cognitive decline.

This sort of book is interesting to me in that someone in my family had Alzheimer’s. I might have mentioned this story before in another book review. It is great to gain hope in the face of such a terrible illness.

The book itself goes over a series of life-changing choices that a person can make to improve their overall health and prevent the possible onslaught of Alzheimer’s Disease or some other form of Dementia. I took this book out of the Library, but I would probably buy it if I had the chance at a used bookstore. I would be more inclined to buy this book if it wasn’t around thirty USD. That’s just me being stingy though.
3 reviews
September 14, 2019
Just wish there were a book like this 50 years ago!

But even now, at eighty, I find "The Alzheimer's Solution" valuable and have implemented some of its recommendations in my daily life.

The book is very readable and the argument put forward by Drs Sherzai simple, persuasive and backed by science: if you live unhealthily, your body and brain won't work optimally and you increase your risk of Alzheimer's and other lifestyle diseases. This makes sense.

After finishing the book, I have already made some recommended changes in my daily routine: I no longer sit reading for hours on end without getting up at least once an hour and I try to go for a morning walk. Also, because I am a bit wobbly on my feet, I am doing balance exercises from the book. (But the recipes were too 'radical' for me, I made no changes there).

This is a great book. Read it whatever your age!




Profile Image for Josée Leon.
654 reviews20 followers
October 29, 2019
This book should be required reading for everyone, doctors included. Just like we need to take care of our bodies to avoid heart disease, diabetes, etc., we need to use preventative measures to look after our brain health in order to avoid cognitive decline. It's about lifestyle choices such a nutrition, exercise, quality sleep, dealing with stress, etc.
This book is backed by quality research and shows that cognitive decline can also be reversed. Of course, the sooner you act after the onset of cognitive decline, the better your chances of reversing it.
The industry really needs to accept that finding a drug to miraculously cure Alzheimer's is not the way to go. Doctors and specialists need to help patients create a personalized lifestyle plan to help them avoid and reverse this dreaded disease.
Profile Image for Jennifer.
309 reviews7 followers
June 8, 2022
I listened to this book as an audiobook in my car. I gained a lot of knowledge from listening to this book. My big takeaways were that you can make lifestyle chances to help your brain, those changes are better than taking medicine, eating chicken is not recommended because it is high in saturated fat, daily exercise that gets your heartrate up and makes you sweat is very important, making healthy lifestyle changes in your 40's is very beneficial to your brain's health in your older years, focus on eating a diet rich in plants, vegetables, legumes and healthy grains, eat as little meat as possible or no meat, eggs are not the best choice, sugar is terrible for your brain and causes lots of problems including inflammation and getting good sleep each night (good quality sleep, 7-8 hours per night, no more, no less) is the best.
Profile Image for Elise A.
497 reviews28 followers
April 6, 2023
For ten years I’ve been helping my parents and MIL through their declining years. Watching my paternal grandmother, aunt and father deal with dementia, Parkinson’s and Alzheimer’s fills me with urgency to learn all I can.

The authors compiled findings from extensive research, knowledge from decades of clinical practice, and loads of suggestions for us, the public, who are interested in staving off Alzheimer’s. We can do it!! They explain how our dietary habits, typically sedentary or stressed out lifestyle, and poor sleeping habits all contribute to our brains losing optimal function as we age.

Nothing in this book is overwhelmingly scientific, yet the information is backed by documented science. The authors include in each chapter practical options for us to embrace in our lives including menus and recipes, games, mental exercises, and more.
34 reviews
March 27, 2019
This book is actually very practical and contains information everyone SHOULD know-take good care of your body, including nutrition, exercise and reducing stress, and you will live longer. However, this book really hit home for me and made me look at Alzheimer’s a bit differently. Taking care of your body means taking care of your brain and the authors lay out the research for this. The only reason I’m not giving this book 5 stars is because I didn’t appreciate that the authors painted the entire medical community with a broad brush and insinuated doctors don’t know what they’re doing. There are bad doctors just like there are bad teachers and police officers, but that doesn’t mean all medical doctors are bad and don’t care for their patients.
Profile Image for ReadingMama.
1,020 reviews
May 14, 2020
Drs Sherzai, leading researchers and doctors at Loma Linda University provide practical tools to reverse the symptoms and prevent cognitive declines. Alzheimer’s disease is not a genetic inevitability and disease can be delayed by 10-15 years by following NEURO program:
Nutrition: mainly plant based diet without meat, salt, or sugar
Exercise: movement every hour is recommended
Unwind: stress relief by meditation and breathing exercise
Rest: 7-8 hours of good sleep
Optimize: active brain from studying, reading and constantly challenging

In conclusion, people living a healthy lifestyle have lower prevalence of dementia and other medical issues. Am I surprised? of course not!
Profile Image for Road Worrier.
461 reviews2 followers
May 11, 2021
Highly recommended to anyone who is alive. Great suggestions to live a healthier life which as a byproduct either maintain or improve your brain function! They seem obvious enough when you hear them, but now you've got a good reason to get good sleep, keep your anxiety low, have a healthy diet, and get exercise. Not sure how employees with multiple jobs and low finances will be able to make it work. Sleep is what gives when I want to do enough with my life, I guess I'm going to need to figure out some other way to keep my productivity where I want it. I always have felt I'm active enough, but this book let me know I need to do a bit more in the exercise department... which I love to do. Now I have a mandate to do it!
Profile Image for Alaine Lee.
770 reviews3 followers
October 9, 2022
3.5 Stars. This book was written 4 years ago, and health information changes rapidly. I also want to read The End of Alzheimer's, a similar book. What I really took note of was that by the time Alzheimer's presents at age 60/70 and above, the brain changes have been occurring for about 20 years. So, in some ways, if you have a bad diet, or lack of sleep, or lack of exercise, you may have already set yourself up. This book focuses on lifestyle changes and these can somewhat prevent or help with cognitive impairment: nutrition-exercise-sleep-stress management-and optimize(keeping the brain active). I think it is overall good check in for my aging body-while we cannot be perfect, we can set up and try to maintain good habits.
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