This is not an easy read for laymen, so if you're not in a neuro-doctoral program or residency, you might be hard pressed to get to the end. I had read one of Mr. Siegel's other books which was not as scientific and technical. With that said, here are the highlights for me. Being mindful is a way of becoming your own best friend.
Mindful awareness is paying attention. This can improve healing, immune response, and overall life. There's tons of acronyms like MAP, COAL, SOCK, which refer to traits one needs to be mindful. Curiosity, openness, acceptance, and love = COAL. There are chapters on brain basics with diagrams and more. You've got your Left/Right dichotomy. Left for linguistics, linearity, logic, literal thinking. Right for non-verbal, holistic, visuospatial, autobiographical memory, emotion. Creativity is from integration of both.
The author immersed himself in a week of silence and other mindful retreats and I found those very interesting. When he gives examples, it's easier to comprehend and relate to the concepts at hand.
Being in the present and get rid of top-down concepts. (So many people I know are closed minded and could use a little mindful meditation!) Try to be non-reactive, regulate your emotions, etc. He sites lots of other scientists, psychologists, etc., and provides references in the back. I enjoyed the chapter on education and how the typical learning in public schools is antithetical to this way of thinking and they should adopt some of these practices to help students achieve better outcomes. Resiliency should be taught in the schools, at young ages.
In short, you can change your brain, neuroplasticity, and become more compassionate and kind. Sign up for meditation, breathworks, yoga, or tai chi and see if it makes a difference in your life.