The drama centers on the relationships between his main protagonists, Octavius Ceasar, Mark Antony and Cleopatra and the highly charged affair between Mark Antony and the Egyptian queen that forms the backdrop to the pervading theme of struggle between East and West throughout the play. The internal battle of personal emotion and duty that Antony experiences and the dynamics of power and sexuality portrayed by Cleopatra, give the play its dramatic tension.
El genio de Cleopatra nada tenía de masculino, ni trataba de imponerse violentamente a los hombres; para eso era demasiada mujer, y de ahí nace el secreto de sus triunfos.