Before it was adapted for a forthcoming Captain America movie, Civil War was Marvel's attempt to graft the mutant dilemma of the X-Men onto the rest of its landscape, so that everyone was at war at each other. The term "Avengers Initiative," likewise later appropriated by the movies, came from this series, a lackluster follow-up to Civil War that imagined what the revised landscape would look like.
If nothing else, it ably demonstrates how little the idea was thought out, more like a failed attempt at creative expansion, and inexplicably by the end of this second and concluding volume, the worst art imaginable for a mainstream comic book.
Writer Dan Slott would go on to become the longest-running Spider-Man writer (outside of Brian Michael Bendis, who until recently specialized in non-canon stories) I personally know of, responsible for a string of storylines including the Dr. Octopus-becomes-Spider-Man that ran in the series called Superior Spider-Man. Christos Gage was simultaneously co-writing some of the best G.I. Joe stories ever for IDW, along with Mike Costa, under the Cobra banner. I have to assume editorial didn't want to see anything too impressive from them, asked to see something a little more lightweight.
The result is like Marvel publishing generic superhero comics you'd see from d-list companies. The series ignores its own premise, introducing characters who need no real training, are unleashed in the very same ways that ostensibly created the very disaster that sparked Civil War, and so many of them, and mixed with enough veteran characters, that the storytelling makes it very hard to care about any of them. (Two of the new characters are clearly derived from the Top Cow formula. If you know what that means, congratulations.) And it just goes on and on.
And yes, by the end, the art sucks. So don't even bother. Go see the movie. As far as the comics go, just remember: Captain America eventually came back from the dead. (And by some extraordinary, I mean even for comics, bending of logic, was never even dead to begin with...) Surprisingly, his death doesn't impact anything in this comic. Figures.