A renowned authority on diseases, presents a radical theory about the origin of deadly microbes in a book that takes us into the "hot zones" of today's most dangerous viral outbreaks, then into the research labs and hospitals where doctors and scientists are risking their lives trying to control them.
AIDS, Ebola, "mad cow disease," "flesh-eating" viruses...Today's newspapers are full of articles about new plagues and viruses. Where do these new viruses come from? Why do new plagues arise? Could there be -- will there be -- a lethal and incurable Virus X that spreads as easily as the common cold?
Frank Ryan is a consultant physician in the UK as well as being an innovative evolutionary biologist, who has introduced the concepts of aggressive symbiosis to virology, and the concepts of genomic creativity and the holobiontic human genome to the story of human evolution. His major scientific interest has been the pioneering and development of the concept of viruses as symbionts, thus bringing together the disciplines of evolutionary virology and symbiology. He has a major interest in the evolution of the human genome and the implications this has for medicine.
BOOKS
Frank's books include the recently published "The Mysterious World of the Human Genome", Virolution, Metamorphosis, Darwin's Blind Spot, Virus X, and The Forgotten Plague. World in Action and Horizon based programs on Frank's books. The Forgotten Plague was a non-fiction book of the year for the New York Times. Virus X also received outstanding reviews in the New York Times and The Washington Post's Bookworld, and Darwin's Blind Spot was the book of choice for Charlie Munger in 2003.
Frank's books have also been the subject of TV and radio documentaries and have been translated into many languages. He is also an occasional reviewer of books for the New York Times.
SOCIAL LIFE
Frank is married with two children. He is an entertaining speaker, which has helped to make him popular with the live media, professional colleagues and lay audiences alike.
I read this for research on my new book. Interesting, if long, read. Well-written, hence the 3 stars. But I have some issues, hence the 3 stars. One: obviously, it's written by a doctor. Terms like 'desquamation', 'teratogenicity' litter the text without translation. Two: it's written by a medical doctor. Viruses in plants are touched on (barely). Three: bioweaponising of viruses is never mentioned. Vaccination/therapeutics of viruses are mentioned (in one paragraph only). Yet viruses aren't only pandemic causing; perhaps sometimes they are beneficial, even benevolent. Finally, I'm not so sure about the doomsday scenario painted in the book; public health teams are better prepared, I think, than the author allows. However, Virus X is a useful, rather sobering reminder, especially in light of the current ebola virus outbreak.
This is a bit out of date now, in that there are emerging viruses it doesn’t touch on and scientific advances in studying them that it doesn’t include, but it’s still a fascinating glimpse into some of the emerging diseases of the last century or so, how the outbreaks were handled and what they mean. If you’re read David Quammen’s Spillover, it’s somewhat along the same lines, discussing many of the same diseases; it’s been a while since I read Spillover, so I found this a good refresher on the diseases mentioned and the early stages of their emergence.
If you find this whole subject a little stressful, this won’t exactly be reassuring; it does show that the world simply doesn’t have the infrastructure to deal with the kind of pandemics that are coming our way. We’ve been lucky so far — I’m honestly shocked there’s been nothing worse since this book was published.
Virus X: Tracking the New Killer Plagues, by Frank Ryan, MD, details various epidemics and outbreaks, the known or proposed vectors thereof and efforts of healthcare authorities (local, federal-CDC, and worldwide-WHO) to stop the spread and treat the victims. The topic is right down my alley, but I must say, this was 2/3 of a good book. I enjoyed the epidemiological discussions & the sleuthing aspect of them. I liked the discussion of co-evolution of species – namely that of some diseases and their hosts – to explain micro-outbreaks (e.g., Ebola) in other species; why some species don’t appear to be affected; and the explanation of why some germ hasn’t wiped out our species yet. What I didn’t like was Dr. Ryan’s P.C. treatment of HIV/AIDS and his goofy descriptions of the epidemiological players (researchers, physicians, etc.) – really gaack. He could have cut down the length of the text too – at times he just went on and on with the tracking down of a virus in nauseating detail, and I just wanted him to come the punchline. I think Dr. Ryan was trying too hard to make the subject matter accessible for the layman, but it wasn’t altogether necessary. That said, for anyone who enjoys reading virus-hunter type stuff, it’s an interesting read.
Dropped a star due to increasing irrelevancy, not because it wasn't any good. Each of the "new killer plagues" has either 1) been covered by an earlier book, with no new information added, 2) has a better book written specifically on that pathogen (and if I weren't defending in 2 weeks I'd look them up and reference them here. Alas, PowerPoint calls.), or 3) developed so far beyond what Ryan has written about that should really find a more recent book. (Ebola, this is all you.)
British science journalist and physician Frank Ryan covers a lot of ground in this extensively researched and engagingly written trek into the world of emerging viruses. These viruses, indigenous to disturbed areas of the world, particularly in the tropics, are now being sprung loose to threaten humankind.
The first third of the book covers the story of the "Four Corners" hantavirus that jumped from deer mice to humans with fatal effect in the southwestern United States in 1993. This is science journalism at its best.
In the next third of the book Ryan takes us to the jungles of Africa and traces the origin and effect of the horrendously brutal Ebola virus. Again he tells an engaging story with a pictorial vividness. One is amazed at the courage and dedication of the health care workers and medical scientists who risked their lives to treat the sick and dying and to find the source of the deadly disease.
At the beginning of the last third of the book, Ryan reprises what we know about HIV, its origins, its spread, the political and social stupidities involved in its spread, and the prospects for combating this terror. Again he makes the personalities and the nature of their work come to life. Then beginning with "Chapter Sixteen: The Aggressive Symbiont," Dr. Ryan discusses in general and theoretically the evolutionary nature of viruses, where they came from, why they exist and what we can expect from them in the future. Most pointedly he explores the possibility of a doomsday virus that is simultaneously as easily spread as influenza and as deadly as Ebola.
In a sense this part of the book, originally published in 1996, predicts the SARS outbreak, but does not stop there. Ryan argues persuasively that, because of increased international travel, because of increased disturbance of natural environments, especially equatorial forests, and because of lack of sufficient preparedness, we are in mortal danger from a horrendous pandemic caused by an emerging virus, a virus he dubs "Virus X."
Part of his argument comes from the realization that every species on the planet harbors viruses. Most of these viruses exist in the host in a relatively benign manner. Ryan believes that virus and host are in a symbiotic relationship that has developed over the eons. The host shelters the virus while the virus, when shed into the environment, attacks other species with a deadly ferocity that protects the ecological position of the host. He calls this virus the "aggressive symbiont." It is here that Ryan's thesis is somewhat controversial.
For my part I think it is better to explain the deadly ferocity of an emerging virus by observing that the virus is killing its new host not to protect the old one but because it has not yet fine tuned its relationship so as not to kill the new host. Also the new host has not yet developed mechanisms for dealing with the virus to prevent it from doing egregious harm. Yet, it is valuable to see the virus as an "aggressive symbiont." Clearly the viruses (and other diseases) of the African rain forests are one of the reasons, as Ryan points out--perhaps the most important reason--that those jungles are still standing. It is clear that the AIDS virus that jumped from chimpanzees to humans would, in the pre-modern world, have the long-term effect of keeping humans from successfully usurping their territory. Perhaps it is best to say that viruses help to maintain the existing ecology.
However, to resolve this controversy will require predictive scenarios and experiments by scientists in the field. We should have a better understanding (and perhaps some more precise terminology) a few years down the road. For more information on symbiotic relationships see Ryan's recent and very excellent, Darwin's Blind Spot: Evolution Beyond Natural Selection (2002). Another excellent book on a closely related subject is Parasite Rex: Inside the Bizarre World of Nature's Most Dangerous Creatures (2000) by Carl Zimmer where the emphasis is on the parasitic stage of symbiosis.
One of the most interesting ideas Ryan presents is that of "genomic intelligence." We are accustomed to thinking of intelligence in terms of computer chips or neurological growths, but perhaps the most important intelligence on this planet is of another kind, something like that of the ant colony or our immune system or that contained in the form and "behavior" of the virus. Consider, as Ryan does, that the virus has been co-evolving with its hosts, beginning with single-celled bacteria for perhaps a couple billion years or so. During this vast expanse of time it has "explored" the "landscape of the genome" (p. 226) and come to "understand" it so well that it is able to use the genome of virtually every creature on earth for its reproduction. Yet, the genome itself has its intelligence that has allowed it to continue to reproduce itself despite what the viruses are doing. This sort of intelligence cannot be discerned from examining the virus or the genetic code alone because such intelligence exists in concert with an environment at the molecular level of shapes and surfaces that is only expressed through the dynamics of growth. As in an ant colony there is no centralized "authority" where this intelligence exists; indeed the intelligence is an emergent property of the entity's interaction with its environment.
This book is therefore more than just a compelling report on the threat we face from emerging viruses, but an exploration of the evolutionary significance of our place within the viral environment. It is so well written, so well thought out and still so entirely pertinent to what is happening today that I would like to see Ryan revise it to include material on SARS and other outbreaks and to bring us up to date on what is now being done by the World Health Organization and other institutions to fight the grave dangers we face.
--Dennis Littrell, author of “Understanding Evolution and Ourselves”
This book is incredibly well-researched and well-written. Frank Ryan's look at emerging viruses is thorough and engaging. He gives enough molecular biology background that readers with a shaky biology background can understand disease mechanisms at the cellular level AND he manages to keep it from getting too dry. Ryan covers the emergence of the hantaviruses, Machupo, Lassa, Ebola, and HIV as well as touching on a few emerging bacteria such as Beta hemolytic streptococcus.
My favorite chapter is 16, The Aggressive Symbiont, in which the author discusses the theme of coevolution as it applies to viruses and their hosts. He suggests first a closer look at the concept of intelligence, defining it as "the ability to receive important information about its surroundings and then to be able to change its behavior, perhaps its very heredity, so as to respond to that information" (p. 302). Instinct is an example of such intelligence, and as another example, he cites "genomic intelligence" to refer to the "capacity of the genome to be both receptive and responsive to nature" (p. 303). He suggests that this genomic intelligence leads viruses to evolve with their natural hosts from a predator-prey relationship to a symbiotic equilibrium in which the virus becomes non-lethal to the host (p. 308).
Ryan suggests that, like ants that are symbionts with rattan cane in Borneo and attack herbivores who try to eat the cane, viruses come to an "aggressive symbiosis" with their hosts (p. 309). The viruses protect their hosts by infecting beings (human and otherwise) who encroach on the host's ecological niche.
A little dated (1997), but hearty and informative. Fun and interesting read. It was hard not to compare this book to The Hot Zone, which I read ad nauseum during high school. I was delighted to find that it had more information, including real names and more specific locations in Africa, and a juicier story of what happened at Reston (I knew that the virus jumped species into humans, but was unaware that people actually got sick). Also, his account of the Zaire outbreak was equally exciting and graphic. I got the sense that Dr. Ryan really enjoys thesauruses, and he really likes to assume the worst (saying that one in one-hundred people will have AIDS by the 21st Century), but with all older science/doomsday books, it's just another "fact" to chuckle at. I think I missed the part where I was supposed to be scared, and even Ryan seems nonplussed as he hems and haws between "diseases are important ways of controlling population, and species only have a lifespan of one million years anyway" and "diseases might entirely wipe out the human race and we deserve it because we are unprepared".
This is about some of the viral plagues that have been emerging over the past couple of decades. Specifically, it talks about hantavirus, ebola and HIV. It describes how many of these organisms work and how they have evolved into the killers that they are.
It makes on scared about the possibility of another such virus striking in the future.
The book was a little bit dated. I would have enjoyed a more updated version that discussed H1N1 and so forth. But viruses are fascinating creatures and scary.
Fascinating. Viruses are scary. I mean, really scary. Of things I try not to wish upon people, Ebola is one of those things.
Anyway, this book is really interesting. It goes and describes the rise of a few epidemic viruses. The Sin Nombre Hantavirus from 1993 or so, the Ebola outbreak from 1976, and some others. It goes through some of the cases like a mystery novel. Describing the behind the scenes processes involved in identifying these diseases and how they were transmitted.
An interesting book that outlines epidemics and viral outbreaks that have occurred throughout recent civilization. There is discussion of how scientists discover these viruses and try to trace them back to their host species. We learn how viruses evolve, how some have a symbiotic relationship with their host and are introduced to theories on why epidemics suddenly flare up. It is written at a fairly high level but you don't have to be a science nerd to get the gist of this book.
A fascinating look at viral infection, and what it means for our continued survival-and possibly evolution. I read this book when I was just in middle school, and it has influenced me so much in my thought, even now pushing me towards Microbiology in my college courses. Its a fascinating read, and I highly reccomend it.
A well written book though partially for the non scientist and partially for the scientist. Our author gets a little carried away with technicalities which does make the book slightly painful in parts.
Overall a very insightful thought provoking text and despite its age, it is still extremely relevant today.
This book was interesting but far too technical for my needs. Reading some of the facts about viruses compared to current world conditions makes me realize that we are lucky a major virus has not decimated most of humanity - yet.
This was excellent. The author details some of the most recent emergent viruses-Ebola, Hanta, and HIV-and their origins. Particular attention is paid to humanity's impact on the environment and how this has led to outbreaks.
I love the way the author explains the different medical outbreaks in this book. I know to some it may seem dramatic, but I like the author’s concept. I believe there will always be changes in nature that we have to learn to overcome or change. The plastic eating bacteria we created comes to mind!
A fascinating background to viral science. Even someone with basic science knowledge can enjoy this book. Well written and pulls the reader into the world on a microscopic level.
Some people might find this tedious but I thought it was a good read. This book shows you how medicine, viruses and societies evolve. I recommend it to those interested in any of those three.
"Virus X by Frank Ryan M.D. is an extraordinary journey into the invisible world of viruses, narrated with the perfect blend of scientific precision and compelling storytelling. Dr. Ryan, a highly acclaimed virologist, uses his vast professional experience to weave a masterful narrative that is as enlightening as it is engrossing.
The book delves into the emergence and impact of various deadly viruses that have plagued humankind throughout history, from the familiar HIV and Ebola to lesser-known threats like the Hantavirus. Dr. Ryan’s ability to explain complex scientific phenomena in clear and accessible language is nothing short of remarkable. He meticulously breaks down how viruses operate, mutate, and spread, providing readers with a thorough understanding of their deadly potential.
One of the most striking aspects of Virus X is its thoughtful examination of the relationship between humans and viruses. Dr. Ryan skillfully contextualizes each viral outbreak within its social, economic, and environmental frameworks, offering insights into how human behavior and ecological changes contribute to the rise of these pathogens. His analysis underlines a profound, often unsettling, truth: that the deadliest enemy is not the virus itself, but humanity's negligence and unpreparedness.
Each case study is vivid and gripping, filled with real-life drama that reads like a medical thriller. Dr. Ryan includes poignant personal anecdotes that bring a human touch to the scientific data, making the gravity of the situations feel immediate and real. His compassionate portrayal of patients and front-line health workers elevates the narrative, turning abstract statistics into moving stories of courage and resilience.
Furthermore, the book is a timely wake-up call in the wake of recent global health crises. Dr. Ryan’s discussions on the importance of vigilance, research, and international cooperation in combating viral diseases are more relevant than ever. He also emphasizes the critical role of science and innovation in our ongoing battle against viral threats, instilling a sense of urgency and hope.
In Virus X, Dr. Frank Ryan has penned not just a scientific recount of viral infections but a vital narrative that underscores the interconnectedness of global health. It is a chilling yet fascinating read that will captivate anyone interested in epidemiology, public health, or simply an expertly told tale of survival against odds. I cannot recommend this book highly enough. It is not only educational but also deeply thought-provoking and extraordinarily engaging."
4/5 stars. I wanted to give 5/5, but I'll get to that in a second. This book is FANTASTIC. I'm a biochemist, so the technical terminology wasn't at all too much for me, and I think Ryan did a great job at explaining methods and theory he talked about. I'm really interested in plague viruses, so the emergence of viruses and how they were tracked and studied was what I wanted to read about. I got so much more than just facts about viruses. Let me tell you, I have taken virology and disease classes. This book introduced theories that were never touched on by my coursework. Ryan wrote about the prejudice that stalled the realization of the AIDS pandemic, included the idea of aggressive symbiosis, covered antibiotic resistance and some bacterial plagues, and detailed the features of what a killer virus would have. I LOVE THIS BOOK. My one compliant: it is outdated. I would love to see an updated and revised version that included the 2014-2016 Ebola outbreak (even though that wasn't its initial emergence), recent scientific techniques, updates about antibiotic resistance, updated theories of viral emergence, evolution, and aggressive symbiosis, and, of course, the SARS-CoV-2 pandemic. This book combines thriller stories and scientific facts... and is nonfiction.
This is the second time I’ve read this book. Great research, lower stars just because every scientist involved seems to be named and described, which is fine, but obstructs reading for me. Basically this is the background history about Hantavirus, Ebola, and HIV for the most part, with other viruses touched upon as well, but not as deeply. Makes a good case for why we need more money and more expertise readily available to lessen the effects and reach of new viruses that can start pandemics!
Reading about emerging viral plagues in the middle of a global pandemic is oddly satisfying. However, this book was simply too outdated. The information is good, it’s just almost 25 years old, and there have been too many technology advances in that time for this to still feel relevant. I love the premise and would be intrigued to read something similar written more recently.
This book is dated and long winded with lots of medical terms without explanation, which really slowed down my reading. The premise is solid and some of the information was interesting but not enough for me to give it more than two starts.
I only gave this three stars the first time I read it, but enjoyed it significantly more the second time. Very strongly researched and interesting book.
This is a very good book. The author is well educated and engaging on the subject. In light of 2020, some sections are down right prophetic. I would love to see updated chapters to included SARS, MERS, Avian flu, H1N1, and Covid.
Two notes: the editor of the digital version missed several misspellings and typographical errors. This was a minor distraction. Second: the book would have been enhanced with pictures of the viruses and scientists, and in the last chapter, of the animals referenced. While not necessary, they would have been a wonderful inclusion.