I wanted to like this book more than I did. Dr. Nuland's writing can be a little old fashioned and dense, but my main complaint is his personal musings and anecdotes. In the chapter on sex, a story of him as a young boy being hit in the groin with a baseball was a little jarring, even if it did explain how certain anatomical features work.
My other issue was with the anti-atheist and anti-skeptical tropes that Dr. Nuland used. Despite him repeatedly writing that he attributed none of the wonder of what he calls the human spirit to the supernatural, he writes things like how science is just another belief system, and that "TRUE skeptics" keep their minds open because anything is possible. This makes him come across as someone prepared to dismiss criticism of his own ideas.
I've liked other of Dr. Nuland's books, and I enjoyed the medical stories and explanations in this book of how the body is put together and works, but this one was a real struggle to get through.
Because I read the paper edition of this book, I'll include my highlights here:
Sharon was speaking about that of the human spirit which sustained her. But it would be a mistake to rely on it as necessarily a factor in recovery from sickness. There are those who don't give up and yet die anyway - just as there are those who do give up and yet live in spite of their "wrong attitude". ... My clinical observation leaves me with conflicting beliefs. For every Sharon Fisher, I have known a dead optimist. p. 64
The human way is that the simplest stimuli are sufficient to send all manner of signals along all manner of pathways, and to make something vastly complex of what was biologically meant to be quite clear. Sexual reproduction is apparently too direct for us - we have taken on this enormous bundle of baggage we call sexuality. The first small stirrings of sensual thought inevitably lead to an uproar of possible response, taking us finally to regions of mental reconnaissance unknown to any other creature, and demanding choices that determine the pattern of an individual's life - and through him and millions like him, the pattern of a culture. p. 159
There is probably no human function more genetically predetermined and yet more susceptible to nurture and individual variation than the method by which we reproduce our kind. p. 177
What we call the mind is an activity .... p. 349