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Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics
Many of the cells in our body undergo tightly regulated replication to enable growth to occur, and to ensure that damaged or worn out tissues are replaced. Regulation is mediated via many different mechanisms; it is when these mechanisms fail, and regulation is lost, that cancer can result.
Recent advances in molecular cell biology have greatly expanded our understanding of the processes and mechanisms which underpin the regulation of cell replication, and what is happening at the molecular level when these fail.
The Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics offers a fresh approach to the study of the molecular basis of cancer, and shows how our understanding of the defective mechanisms which drive cancer is leading to the development of new targeted therapeutic agents.
Opening with an overview of the key hallmarks of cancer as a disease state, the book then leads us through the principal components of the regulatory machinery through which cell division is controlled, and explains how the failure of these components can lead to the onset of cancer. Uniquely,
within each chapter, students are shown how this molecular knowledge is being applied to develop new targeted therapeutic strategies.
The Molecular Biology of Cancer will prove a valuable resource for any student wishing to gain an insight into the molecular basis of the disease, and possible solutions for its effective control.
Companion Web Site
Features figures from the book available to download, to facilitate lecture preparation, and a web link library to give students easy access to relevant online resources.
Recent advances in molecular cell biology have greatly expanded our understanding of the processes and mechanisms which underpin the regulation of cell replication, and what is happening at the molecular level when these fail.
The Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics offers a fresh approach to the study of the molecular basis of cancer, and shows how our understanding of the defective mechanisms which drive cancer is leading to the development of new targeted therapeutic agents.
Opening with an overview of the key hallmarks of cancer as a disease state, the book then leads us through the principal components of the regulatory machinery through which cell division is controlled, and explains how the failure of these components can lead to the onset of cancer. Uniquely,
within each chapter, students are shown how this molecular knowledge is being applied to develop new targeted therapeutic strategies.
The Molecular Biology of Cancer will prove a valuable resource for any student wishing to gain an insight into the molecular basis of the disease, and possible solutions for its effective control.
Companion Web Site
Features figures from the book available to download, to facilitate lecture preparation, and a web link library to give students easy access to relevant online resources.
262 pages, Paperback
First published January 1, 2005
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Displaying 1 - 4 of 4 reviews
April 6, 2025
Managed to find it at the local university library. Quite technical for a non-medical person like myself. But I did note many interesting aspects while reading the most digestible parts:
> The chemicals from sunscreen are cancer producing (photosentisized carcinogen)
> Vitamin D protects from cancer but sunscreen prevents production of it. Tanning is a self defence mechanism against excessive UV absorption
> Cooking meat in high temperatures creates carcinogenic compounds
> helicobacter pylori is a virus that is carcinogenic
> Skin peeling off after sunburn is a normal process that helps prevent skin cancer, by killing the cells that have had the dna modified. But then I wonder what happens when applying aloe vera gel, is it just that the cells killing response (apoptosis) is not initiated or is it that the DNA is repaired?
> If the genes that causes Brest cancer are activated in 50-80% cases, what do other that do not get it activated do differently?
> Mold produces cancer
> Tomatoes grapes and garlic have anti cancer properties
> Hpv infection is usually cleared by the immune system and does not affect a person’s health, but chronic infection over years causes cancer. The majority of hpv infections will be transient with a clearance time of 6-18 months.
> The chemicals from sunscreen are cancer producing (photosentisized carcinogen)
> Vitamin D protects from cancer but sunscreen prevents production of it. Tanning is a self defence mechanism against excessive UV absorption
> Cooking meat in high temperatures creates carcinogenic compounds
> helicobacter pylori is a virus that is carcinogenic
> Skin peeling off after sunburn is a normal process that helps prevent skin cancer, by killing the cells that have had the dna modified. But then I wonder what happens when applying aloe vera gel, is it just that the cells killing response (apoptosis) is not initiated or is it that the DNA is repaired?
> If the genes that causes Brest cancer are activated in 50-80% cases, what do other that do not get it activated do differently?
> Mold produces cancer
> Tomatoes grapes and garlic have anti cancer properties
> Hpv infection is usually cleared by the immune system and does not affect a person’s health, but chronic infection over years causes cancer. The majority of hpv infections will be transient with a clearance time of 6-18 months.
January 28, 2022
I read the 5th edition that just came out in 2021. It was a well-structured textbook with clear writing, easy to understand figures, and thoughtful call-out boxes. It does not go into significant detail but it does lay a good foundation for additional advanced study. The book could probably benefit from an abbreviations list. Overall, good textbook.
May 30, 2020
Great textbook
April 30, 2019
I referred to this book to complete an essay on cancer metastasis and it was very helpful. All the knowledge of cancer is perfectly summarised and presented in a very user-friendly manner. I would definitely recommend this book for people looking to learn more about cancer.
Displaying 1 - 4 of 4 reviews