It's been a year since Dr. Bartholomew Burke turned his girlfriend over to the Greys to be saved from a deadly poison circulating throughout her body. He has given up his practice and lives in a cabin in the woods where he is taught by the hybrid-alien girl Rika about how to save the environment. One day his friend Dan Rogers shows up at one of his lectures and informs him about strange things that are happening. Human mutilations, strange sea creatures washing up on shore, an increase in alien abductions, all point to something big. Again, Dr. Burke joins forces with his friends to get answers. He also finds out that the human-alien fetus of his girlfriend is a major component in this mystery.