The End of Alzheimer's Program: The First Protocol to Enhance Cognition and Reverse Decline at Any Age

by Dale E. Bredesen, David Perlmutter (Foreword)

The instant New York Times bestseller

The New York Times Best Selling author of The End of Alzheimer's lays out a specific plan to help everyone prevent and reverse cognitive decline or simply maximize brainpower.

In The End of Alzheimer's Dale Bredesen laid out the science behind his revolutionary new program that is the first to both prevent and reverse symptoms of Alzheimer's disease. Now he lays out the detailed program he uses with his own patients. Accessible and detailed, it can be tailored to anyone's needs and will enhance cognitive ability at any age.

What we call Alzheimer's disease is actually a protective response to a wide variety of insults to the brain: inflammation, insulin resistance, toxins, infections, and inadequate levels of nutrients, hormones, and growth factors. Bredesen starts by having us figure out which of these insults we need to address and continues by laying out a personalized lifestyle plan. Focusing on the Ketoflex 12/3 Diet, which triggers ketosis and lets the brain restore itself with a minimum 12-hour fast, Dr. Bredesen drills down on restorative sleep, targeted supplementation, exercise, and brain training. He also examines the tricky question of toxic exposure and provides workarounds for many difficult problems. The takeaway is that we do not need to do the program perfectly but will see tremendous results if we can do it well enough.

With inspiring stories from patients who have reversed cognitive decline and are now thriving, this book shifts the treatment paradigm and offers a new and effective way to enhance cognition as well as unprecedented hope to sufferers of this now no longer deadly disease.

Genres: Health, Nonfiction, Science, Medicine, Self Help, Medical, Brain

352 pages, Hardcover

First published August 22, 2017

About the author

Dale Bredesen, M.D., is internationally recognized as an expert in the mechanisms of neurodegenerative diseases such as Alzheimer’s disease. He graduated from Caltech, then earned his M.D. from Duke University Medical Center in Durham, North Carolina. He served as chief resident in neurology at the University of California, San Francisco (UCSF) before joining Nobel laureate Stanley Prusiner’s laboratory at UCSF as an NIH postdoctoral fellow. He held faculty positions at UCSF, UCLA, and the University of California, San Diego. Dr. Bredesen directed the Program on Aging at the Burnham Institute before coming to the Buck Institute in 1998 as its founding president and CEO. He is the chief medical officer of MPI Cognition.

Reviews

[Craig & Heather Norris · Rating 5 out of 5]

Critically important reading

My wife was diagnosed with mild cognitive impairment while a member of the Kaiser network. They did a few diagnostic tests ,get a MOCA score on my wife of 19, got her drivers license revoked, and essentially said, "this is a terrible disease, there is nothing tone done for it, good luck".

None of the Bredesen Protocol is part of the Kaiser program, and the physicians we spoke with did not even know what a functional medicine physician is, but did not think that Kaiser had one.

Fortunately, we were able to qualify for a Bredesen Immersion program with Dr. Bredesen and a team he assembled of trained functional medicine physicians. Subsequently, we are " all in" with the Bredesen protocol. It is not a diet, bit a complete lifestyle change. My wife' symptoms have not progressed and in many area have improved, just sine April 2017. Yes, the program is challenging and has some expense associated with it, but compared to what? An Alzheimer's unit in a nursing home, not to mention the emotional toll on everyone - does this seem like an easier and cheaper alternative to anyone?

This book and the ReCode protocol offers something that cannot be measured, real hope. I urge you to read the book and take the protocol seriously, it can change you and your loved ones lives.

[Doug Bradshaw · Rating 5 out of 5]

A friend brought this book to me and asked me to read it and then to help him incorporate the protocol into his life to fend off mild cognitive impairment symptoms. The book was recommended to him by a well known MD.

The author is well qualified with an MD degree, a residency in Neurology along with other related postdoctoral work. He has been studying the disease for 20 plus years.

MD's and pharmaceutical companies have been looking for a drug to help Alzheimer's patients for a long time. There are a few drugs that help a little bit, but unfortunately, this type of one drug solution so common in medicine won't work because there are dozens of potential causes of the disease. He has identified 36 causes and that list is growing. He compares the causes to holes in the roof that need to be patched. Patching one or two holes won't do the trick.

The three main categories of the causes of the disease are:

1. Inflammation caused by a multitude of different factors including unhealthy foods, drug interactions, and many others. This inflammation triggers the immune system that can then cause an unhealthy brain environment.

2. Metabolic issues, also caused by a multitude of factors, insulin resistance, lack of the vitamins needed to properly break down foods, unhealthy foods, lack of exercise, daylight, etc. etc.

3. Sometimes there are toxins that can cause serious problems such as mold and a list of others such as lead poisoning, etc.

I have merely touched the surface of each category and the various components of each. The first thing to do to start the "ReCODING" process is to identify which of the 36 holes you have in your roof. Many of the holes are fairly simple to identify, low levels of certain vitamins, high A1C levels, high homocysteine level, BMI over 30, low testerone levels, low cholesterol levels (surprised at that one), and many more. These can be identified with blood labs. Once identified, there is good information involving diet, exercise, supplements and vitamins which will reverse these problems over time.

There are also or toxin tests, pet scans, genetic testing and many more that will probably require help from a doctor. There is also the MOCA Montreal tests that you can do online to measure your impairment level.

It seems to me that this book is excellent for anyone over the age of 45 to read and then to incorporate as much as possible into a healthier lifestyle and prevention, even if you show no signs of cognitive issues. I am excited to get my own blood labs done. I especially enjoyed reading about the many patients who started Recoding and then sometimes reversed the disease and stopped the progression in its tracks.

I'm also planning to watch several YouTube videos that have been posted by the doctor himself and other doctors who are implementing the work into their practices.

[Bharath · Rating 5 out of 5]

If you have known people who have battled Alzheimer’s disease, you understand the toll it takes on the person as well as the family/caregivers. A cruel disease which robs people of their sense of identity and confidence to face others. This is a book I liked – I feel the advice is rooted in good experience & evidence.

It has been known since some time that brains of people with Alzheimer’s have build-up of amyloid-beta plaques – scans have conclusively shown that. Over the years, drug companies have invested large sums of money and found many compounds which can reduce the build-up. And yet, the number of drugs which can arrest or cure Alzheimer’s is still at 0. A sense of helplessness has come to people diagnosed with the disease. While there has been considerable progress in the treatment of other dreaded diseases like heart ailments and even cancer, drugs to treat Alzheimer’s has made no headway. Dr Bredesen offers the following reasons – Alzheimer’s is probably not one disease; at the minimum it seems to have at least three variants and he & his team have identified 36 factors which need to be addressed to effectively arrest progression and even reverse the symptoms. The three types (Inflammatory, Atrophic, Toxic) are recognizable through a combination of genetic, blood and other tests, though most doctors do not consider it worthwhile, as in any case Alzheimer’s is regarded as uncurable.

How modern lifestyle invites Alzheimer’s with a combination of poor diet, lack of exercise & inadequate sleep is also true for general health. The culprits this book identifies – sugar, processed food, meat, dairy, gluten largely match those in other good books I have read – How Not to Die: Discover the Foods Scientifically Proven to Prevent and Reverse Disease and Brain Food: The Surprising Science of Eating for Cognitive Power. There is fairly good and detailed information on the tests you should take, assessments you can do yourself and the treatment options. Since Dr Bredesen offers a holistic multi-pronged treatment approach combining – diet, supplements, ayurveda, herbs, yoga, fasting & exercise, not all in the medical community are convinced that this can be effective, as everybody would be happier if there were just one ‘pill’ which could reverse the disease.

I consider this an important book, especially since I am sure much of this is also sound advice for good all-round health, especially mental health, of course. A regimen well worth adopting, especially if you are in your 40s or later.

[Peter McCluskey · Rating 4 out of 5]

This sequel to The End of Alzheimer's is an attempt at a complete guide to a healthy lifestyle.

Alas, science is still too primitive to enable an impressive version of that. So what we end up with is this guide that would overwhelm anyone who tries to follow it thoroughly, while still lacking the kind of evidence that would convince a skeptic.

Bredesen provides some guidance about which advice is most valuable - primarily the changes needed to reduce insulin resistance. That still leaves lots of ideas for which it's hard to guess which ones I ought to worry about.

Evidence

The strength of the evidence is somewhat like the evidence against smoking that was available in 1960, or the evidence in favor of masks in March 2020.

The mainstream medical establishment seems more resistant to imperfect evidence than it was in 1960.

This book pays little attention to convincing skeptics or to motivating readers to care about the health benefits that it offers. Most people should read The End of Alzheimer's before deciding whether they care enough to wade through this book.

Exercise is one area where his advice is backed by better evidence than I expected. A meta-analysis of 19 studies of people at risk for Alzheimer's concluded:

Overall, there was a modest favorable effect of exercise on cognitive function (d+ = 0.47, 95% confidence interval (CI) = 0.26–0.68)

New Tidbits

Some examples of new ideas in the book that I found interesting:
* we should brew green tea at no more than 170 degrees to maintain its healthy qualities
* canned tomatoes are especially risky due to the effects of their acidity on BPA
* it's probably healthier to sleep on one's side. The evidence cited is a rather tenuous, but plausible inference from rats

He's added more types to his attempts to decompose Alzheimer's into useful diagnostic categories. That looks like progress, as I can now identify one (vascular) as closely matching my guess about what I'd be at risk for if I were careless about my lifestyle.

Benzodiazepine use is clearly correlated with cognitive decline. It seems unlikely that we'll get anything resembling an RCT on this, but careful controls lend some support to the concern that benzodiazepine is causing the decline.

Changes in his Protocol
His homocysteine advice seems more plausible now. He's removed the suspicious advice to try methionine restriction as a last resort. But he sticks with his target of 7 or lower. I have increasing reason to doubt that that target is feasible for me, and likely for many other people. I guess that other, apparently unrelated, parts of his protocol (SIBO treatment?) may end up enabling me to hit that target. Or maybe his advice to try higher doses of TMG and choline will help. But I suspect I'll end up settling for a target of 8.

He changed his recommended pregnenolone blood levels from a maximum of 100, to a minimum of 100. I'd like to know why.

My Doubts

Bredesen highly recommends Matthew Walker's "Why We Sleep". A critic says the book is riddled with scientific and factual errors. OTOH, Bill Gates says This book put me to sleep. I can easily imagine that Walker's advice helps most of the people who read it, even if his justifications for the advice are crappy. I'm inclined to guess that Bredesen was right to recommend it, but wrong to not qualify that recommendation.

Bredesen encourages prayer: "some research has also demonstrated that prayer can even positively affect outcomes.", citing a paper which speculates that prayer could produce meditation-like benefits. The paper has good links to support the benefits of meditation, but the link to prayer seems to be just a guess. The paper is mainly about both positive and negative outcomes for people who were prayed for, leaving me confused as to what Bredesen wants us to get out of the paper.

He's more cautious about fruit than I think is healthy. He lists 22 fruits that he recommends, and discourages us from eating others. Maybe that caution is appropriate for people who are recovering from insulin resistance, but I'm pretty sure it's healthy for the rest of us to eat almost any type of whole fruit. Bredesen seems to place too much weight on the Glycemic Index, when a more appropriate measure of risk would say it's safe to eat sugar if accompanied by decent amounts of fiber and other nutrients.

I'm pretty sure these fruits should be considered healthy: baobab, pumpkin, figs, and pretty much any berry. I like berries that he likely hasn't heard of: saskatoonberries, salmonberries, and cloudberries. However, it's hard to get those without added sugar.

Conclusion

He has apparently made slow progress at expanding the network of doctors who understand his protocol - see Josh Mitteldorf's experience. I don't plan to use that network, as I'm getting health support via a somewhat similar functional medicine group.a

It will require plenty of time and attention to get value out of this book. The risk / reward ratio looks good for pretty much all of Bredesen's ideas. I expect that most people over about 55 or 60 will be able to get some benefits from trying out his advice, even though some unpredictable fraction will end up being wastes of time. A small fraction of readers will likely get big benefits.

P.S. Ignore the foreword (written by Perlmutter). Medicine is not polarized between reductionism and holism. The dichotomy I see plaguing Alzheimer's research is closer to the tension between High Modernism and something more Bayesian. Perlmutter is misusing the term reductionism. Bredesen is trying to follow Einstein's advice that "Everything should be made as simple as possible, but no simpler.", and is being resisted because the degree of simplicity that he's been able to achieve so far doesn't match the demands of standard medical practice. Scientism might be a better word to describe what Perlmutter is trying to oppose.

[Gina · Rating 1 out of 5]

This is a harsh rating, but feels appropriate.

The idea is that there are 36 factors that can result in dementia, and so dealing with those factors can reverse it, especially if you catch it early. The 36 sounds like a lot, and it is, but I don't automatically object to that. There can be a lot of complex interactions.

I did have an issue with some of the connections drawn, which seem a little iffy, not to mention trendy.

I have a bigger issue with the contradictions, like the book saying that there is no backup for metals being a cause of dementia, but you should try having mercury fillings removed. Okay, mercury can have toxicity issues (not necessarily for fillings, but fine), but then it is further specified that aluminum doesn't seem to contribute, yet one of the sample routines includes the elimination of aluminum from her deodorant.

In a way that makes sense, because the people who are most likely to jump on bandwagons of clean eating and pure living are the people who will be most drawn to this book. I also do not doubt that when people improve their nutrition and sleep that they do better in many ways. I do doubt that adding all of these supplements as you eliminate some pretty good foods is helpful.

I can almost excuse that everyone cheating on their diet - as determined by visiting health coaches - does not automatically rule out the connection between the protocol and their improvements, given that you might not have an issue with all 36 factors. However, that level of unverifiability, and the scare tactics that are used regarding stopping, and other factors feel like they are adding up to someone not improving just not having found the right essential oil yet, and if it doesn't work you just didn't try hard enough.

I might have given it two stars if it were just kind of scientifically shoddy, but the way it ended up being angered me.

A much better book along similar lines would be The Brain Fog Fix by Mike Dow, which covers similar ground with less pretension.

[Doris Jean · Rating 4 out of 5]

He has a program called ReCODE stands for “reversal of cognitive decline”. ReCODE means to change your lifestyle to recode your brain to stop or reverse Alzheimer's disease (AD). As I read the book, I thought it read as though two authors were collaborating, then at the end he thanked his team of three editor-writers and I think that this team did not work closely enough since the writing was choppy and inconsistent. For example, one section said 50 mg., and another said 100 mg. There were many diagrams and charts and some toward the beginning of the book were so confusing that they were incomprehensible. There were several parts in need of editing for clarity.

Chapter 1 addresses metabolic imbalance of 36 factors affecting AD. Chapter 2 says that the plaques and tangles of AD are a defense for the brain against the 36-factor imbalance. Chapter 3 relates symptoms of AD as recalled by patients who have improved enough to tell how they felt before they improved. Chapter 4 was how to give yourself AD – I would have omitted this chapter completely. Chapter 5 had diagrams of the neuron with plaques and tangles and explained "dependence receptors" and APP (amyloid precursor protein). He explained that APP is a "dependence receptor" (poor diagram, poor explanation) which can be enzymatically cut into either two or four pieces. The two-piece cuts are healthy, the four-piece cuts are Alzheimer's. APP is a prion and with beta-amyloid one gets a self-replicating prionic loop cascade – and Alzheimer's. Chapter 5 was a good chapter.

Chapter 6 was unclear, he is trying to define AD into four types: type 1, 2, 1.5 and 3 which did not make sense – editors? Chapter 7 talked of factors, supplements, advanced glycation end-products (AGE's - from sugar!), inflammation markers, insulin-degrading enzyme (IDE), hormone, thyroid, metals, antibody arrays, the blood-brain barrier, mitochondrial damage, testing, genetics (ApoE4/3), and antioxidants.

Chapter Eight is entitled "Reversing Cognitive Decline" - ReCode seems to be to take vitamin B 6,9, and 12 and trimethylglycine and avoid meat, nuts and beans which give the amino acid methionine which yields homocysteine which is inflammatory. This does not convince me.

Next, he has "DESS" which is diet, exercise, sleep and lack of stress. His "12/3" means one stops eating at least three hours before sleep, so no midnight snacks. The "12" part means that one waits at least twelve hours after the last meal of one day to eat breakfast the following day to help the body into the fat-burning stage of ketosis.

I have been reading many of the newer books on health and it seems that epigenetics is gaining respect. Many now encourage using food in a ketogenic diet to influence genes to improve health. In my opinion the useful information in this book boils down to change your lifestyle to guide your genes toward health. A ketogenic diet will lower insulin (which is being identified as an enemy of longevity because it shortens telomeres). This author also explains that insulin is needed in the brain to clear out sugar but there is an insulin-clearing enzyme (IDE) which is also needed to clear out the beta-amyloid plaques and the insulin will always get the enzyme before clearing the plaques. So high sugar means high insulin which means no enzyme left to clear out the plaques, it will all be used up on the sugar.

He demonizes gluten, but I think it's not only the gluten that is a problem – it's also the glyphosate (RoundUp) which is genetically inside the grain cell and sprayed on the outside of grains to dehydrate for a fast harvest. Glyphosate causes holes in body membranes (leaky gut and leaky blood-brain barrier) and molecules leak through these holes and go into places where they do not belong and cause inflammation and metabolic imbalances. He seems to be a vegetarian, he never recommends eating meat or butter. He recommends "wild-caught" fish which ARE FARMED fish caught in a net out of the fish farm in the ocean, they are NOT wild, but he doesn't seem to realize this. I do not think he means to recommend farmed fish which are not fit for food, they are fed poorly and dyed and genetically manipulated.

Chapter 10 is a summary recommending 1) reduce insulin, 2) reduce inflammation/infection, 3) balance hormones/nutrients, 4) reduce toxins/stress and 5) restore synapses. He didn't say how to restore synapses specifically. Chapter 11 is crutches for cravings: glutamine, MCT's (butter or coconut oil), and more happiness. So eat protein (for glutamine) and animal fat (butter, etc.) to curb cravings is the conclusion, but the author seems afraid to state this outright. Chapter 12 gave brands of supplements and websites. Appendix A gave more websites. Appendix B told about ketone meters. Appendix C told about 23andme for genetics. Appendix D was a fairly good chart summarizing store/forget (blastic/clastic) balance, APP, AD (a plasticity defense against lack of fat, too much glucose, toxins, failure of DESS) and ReCODE to balance the signalling.

This book has mostly useful information, some minor errors, weak editing, weak organization but I think anything that can help someone (especially from the disaster of AD) deserves an extra star, so I now changed my rating from 3 to 4 stars.

[Maureen Smith · Rating 5 out of 5]

This is one of the most important books I have ever read; and I will read it over and over again (in between loaning it out to others). It seems we all know someone who has been diagnosed with Alzheimer's Disease, so this should be a must-read for anyone who doesn't want to accept the current death sentence usually associated with it.
This was an advanced reader's copy, and I expected to find many editing mistakes, but I was pleasantly surprised to find an extremely well written and edited book. I think it would be easy to understand for the average lay person, yet is not boring for someone with medical knowledge.
Dr. Bredesen has been studying and documenting his amazing life work, that is no longer a theory; people have reversed their Alzheimer's Disease by changing their lifestyles.
Dr. Bredesen is sharing important information and is not selling you anything but the book. I already have a list of people who want to read my copy. I wish every medical person I know, every hospital and nursing home dietician, everyone who has a relative with Alzheimer's, and everyone over forty who cares about maintaining their optimal cognitive ability, would read this book.

[Donna · Rating 4 out of 5]

This book is Health & Science. This was between 3 and 4 stars but I'll round up for a few reasons. I've read more than a handful of books lately in this genre, covering all different approaches to our well-being. And this has got to be the first one that didn't feel like it was a giant soap box with agendas. The author covered a lot of material, but not once did he point the finger at someone else's book and put them down....he actually mentioned these other books in case the reader wanted more info on that particular line of thinking.

He made his points.....gave the research that supported it and moved on. At times he even mentioned the pros and cons of a certain food or supplements. Other authors never did that. So this was kind of refreshing. For that alone, I'm willing to round up.

Now this author is heavy on adding supplements. I'm personally not a fan of that when it is heavily relied upon. Sure if there is a deficiency somewhere ... great. But I did like his approach to eating better. Eat whole foods, mainly veggies....exercise....be mindful...and journal.

Overall, I enjoyed this one but here is one BIG cautionary note I'd like to mention. More than a few times, it felt like having a PhD would have been extremely useful in understanding what he was saying. He rarely paused to explain the plethora of acronyms and/or medical jargon. So 4 stars anyway.

[marie · Rating 3 out of 5]

I listened to the audio book and this is one case where I definitely recommend getting the actual paper version and read it since it would be a reference volume. This is far too technical for listening as there are long lists of supplements and their recommended doses being read out. So, my 3 stars is referring only to the audio version. Will change it when I get the hard copy.

[Brendon Gray · Rating 1 out of 5]

https://www.ucsf.edu/news/2020/05/417...

[Designlover · Rating 5 out of 5]

THIS IS A GREAT BOOK !!!

Actually I had received the uncorrected proofs from the publisher,
but that version did not have an (all important) index or some of the graphics.
I ordered and received 5 copies of the hardback version of the book,
which I have distributed to friends.

Here is a review from University of Georgetown Professor, Dr Robert Hedaya, MD:
Dr. Bredesen has written the first comprehensive guide to preventing, halting, and reversing Alzheimer's Disease. It is a must read as it provides you with the tools necessary to understand what Alzheimer's disease is, how to prevent it, and how to treat it. I am a clinician who has been using these methods for more than 2 decades and I know the methods work. This book gives you the blue print you need. Since nearly all of us will be affected directly or indirectly by dementia, this book is required reading if you care about your health, or the health of your loved ones. Robert Hedaya, MD, DLFAPA

more:
https://www.wholepsychiatry.com/lette... /
Alzheimer’s Disease Letter to the Editor Wall Street Journal
Time for a Better Approach To Alzheimer’s Treatments
Alzheimer’s research has failed because of adherence to a flawed model.
April 16, 2017 12:32 p.m. ET


ONE IMPORTANT THING THAT WAS LEFT OUT OF THE BOOK:
Dr. Bredesen's outstanding resume:
http://www.eastonad.ucla.edu/about-us...
( look for it at the end of this review )
Reading this, convinced me Dr. Bredesen is the real deal, an unparalleled example of steadfast research and dedicated determination to find the contributing causes of this insidious disease.

I also spoke with the purchasing departments of the Los Angeles Public Library and the L.A. County Library (Science & Technology reviewers) highly recommending the book (sent email screenshots of some of the text). I am happy to report L.A. County already has 30 copies on it's shelves. LAPL is currently processing it into their system. You can put a hold on it now . . .

I also recommended it for the University of California libraries and the Hawaii State Public Library.

Please ask you local library to purchase it.

It is available in different formats: Hardcover, eBook and AudioBook CDs and downloadable.

Post your review after your read it . . . Pass it on to a friend . . .

Dr. Dale E. Bredesen
CV

http://www.eastonad.ucla.edu/about-us...
Visiting Professor of Neurology, Director of Neurodegenerative Disease Research, UCLA
Education, Training and Appointments
B.S., Biology and Literature, California Institute of Technology, Pasadena, CA, 1974.
M.D., Duke University Medical Center, Durham, NC, 1977.
Resident, Medicine, Duke University Medical Center, Durham, NC, 1978-1980.
Resident, Neurology, Chief Resident, UCSF, San Francisco, CA, 1980-1983.
Clinical Instructor, Neurology, UCSF, San Francisco, CA, 1983-1987.
Hughes Associate, Laboratory of Dr. LY Jan (Drosophila Neurogenetics) Howard Hughes Medical Institute, San Francisco, CA, 1985-1986.
NIH Postdoctoral Fellow, Laboratory of Dr. SB Prusiner (Neurodegenerative Disease) University of California, San Francisco, San Francisco, CA, 1986-1989.
Assistant Adjunct Professor, UCSF, Department of Neurology, San Francisco, CA 1987-1989.
Assistant Professor, UCLA, Department of Neurology, Los Angeles, CA, 1989-1994.
Associate Professor, UCLA, Department of Neurology, Los Angeles, CA, 1994-1995.
Elizabeth R. and Thomas E. Plott Chair, UCLA, Center on Aging, Los Angeles, CA 1993-1995.
Professor and Director, Program on Aging, The Burnham Institute, La Jolla, CA, 1994-1999.
Associate Adjunct Professor, UCLA, Department of Neurology, Los Angeles, CA, 1995-1997.
Associate Adjunct Professor, Neuroscience Department, UCSD, San Diego, CA, 1996-1998.
Adjunct Professor, Neuroscience Department, UCSD, San Diego, CA, 1998-2000.
Adjunct Professor, The Burnham Institute, La Jolla, CA, 1999-2005.
President and CEO, Buck Institute for Age Research, Novato, CA, 1999-2005.
President and CEO, Buck Institute for Age Research, Novato, CA, 1999-2005.
Adjunct Professor, UCSF, San Francisco, CA, 1999-present.
Scientific Director and CEO, Buck Institute for Age Research, Novato, CA, 2005-2006.
Director and CEO, Buck Institute for Age Research, Novato, CA, 2006-2008.
Professor and Founding President/CEO, Buck Institute for Age Research, Novato, CA, 2008-present.
Honorary Professor, Dominican University, San Rafael, CA, 2008-present.
Director, Mary S. Easton Center for Alzheimer's Disease Research at UCLA, Los Angeles, CA, 2013-2015.
Activities and Awards
1970, 1993-1997 Athletic Letters, Caltech (Football, Track)
1970-1974 Alfred P. Sloan Scholar, Caltech
1971 Research Assistant, Caltech (Dr. H. Gray, Inorg. Chemistry)
1972 Research Assistant, MIT (Dr. M. Wrighton, Inorg. Chemistry)
1972 Member, Board of Control, Caltech
1973 NSF Summer Fellow, Caltech (Dr. R. Sperry, Psychobiology)
1974 McKinney Prize for Humanities, Caltech
1974 Graduation with Honor, Caltech
1975-1977 Mary Duke Biddle Scholar, Duke
1977 Brody Scholar in the History of Neurosciences, Duke
1977 Trent Prize in the History of Medicine, Duke
1982 Chief Resident, Neurology, UCSF
1983 Scholarship Recipient, Cold Spring Harbor Neurobiology Seminars
1983 Sandoz Award for Outstanding Neurology Resident, UCSF
1984 Outstanding Faculty Teacher Award, UCSF
1992 Honorable Mention, UCLA Neurology Residents' Teaching Award
1992 Cotzias Award, American Parkinson Disease Foundation
1993-1995 Elizabeth R. and Thomas E. Plott Chair in Gerontology, UCLA
1996 Child Neurology Society Lectureship
1996 Lou and Eleanor Gehrig Lectureship, Columbia University (given for the most outstanding work on amyotrophic lateral sclerosis within the previous year)
1997 United Way Combined Health Agencies Health Hero (annual award for outstanding medical research in San Diego)
2000 Arthur Cherkin Award for Research in Neurodegenerative Disease, UCLA
2005 Gilman-Barbour Distinguished Lecturer, University of Michigan
2010 Editorial Board Member, JBC
2011 Associate Editor, J Alzheimer's Disease
2013 Turken International Lecturer, Neurology Grand Rounds at UCLA
2014 Steven DeArmond Lecture, American Academy of Neuropathologists, Portland, OR

Publications (selected peer-reviewed publications)
• Butterfield DA, Galvan V, Lange MB, Tang H, Sowell RA, Spilman P, Fombonne J, Gorostiza O, Zhang J, Sultana R and Bredesen DE. In vivo oxidative stress in brain of Alzheimer disease transgenic mice: Requirement for methionine 35 in amyloid beta- peptide of APP. Free Radic Biol Med 2010;48:136-144. PMID: 19854267; PMCID: PMC2818480
• Harris JA, Devidze N, Halabisky B, Lo I, Thwin MT, Yu GQ, Bredesen DE, Masliah E and Mucke L. Many neuronal and behavioral impairments in transgenic mouse models of Alzheimer's disease are independent of caspase cleavage of the amyloid precursor protein. J Neurosci 2010;30:372-381. PMID: 20053918; PMCID: PMC3064502
• Spilman P, Podlutskaya N, Hart MJ, Debnath J, Gorostiza O, Bredesen D Richardson A, Strong R and Galvan V. Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease. PLoS One 2010;5:e9979. PMID: 20376313; PMCID: PMC2848616
• Zhang J, Gorostiza OF, Tang H, Bredesen DE and Galvan V. Reversal of learning deficits in hAPP transgenic mice carrying a mutation at Asp664: a role for early experience. Behav Brain Res 2010;206:202-207. PMID: 19751769; PMCID: PMC2783897
• Sperandio S., Poksay, KS, Schilling B, Crippen D, Gibson BW, Bredesen DE. Identification of new modulators and protein alterations in non-apoptotic programmed cell death. J Cell Biochem 2010 Dec 15;111(6):1401-1412. doi 10.1002/jcb.22870. PMID: 20830744
• Bredesen DE, John V, Galvan V. Importance of the caspase cleavage site in amyloid-ß protein precursor. J Alzheimers Disease 2010;22(1):57-63. PMID: 20847422; PMCID: PMC3968071
• Descamps, O, Zhang, Q, John V, Bredesen DE. Induction of the C-Terminal Proteolytic Cleavage of AßPP by Statins. J Alzheimers Dis 2011;25(1):51-57. doi: 10.3233/JAD-2011-101857. PMID: 21422530
• Mehlen P and Bredesen DE. Dependence receptors: from basic research to drug development. Sci Sign 2011 Jan 25;4(157):mr2.
• Poksay, KS, Madden DR, Peter AK, Niazi, K, Banwait, S, Crippen D, Bredese DE, Rao RV. Valosin-containing protein gene mutations: cellular phenotypes relevant to neurodegeneration J Mol Neurosci 2011 Jun:44(2):91-102. PMC: PMC3084943
• Orcholski, ME, Zhang, Q, Bredesen DE. Signaling via amyloid precursor-like proteins APLP1 and APLP2. J Alzheimers Dis 2011:23(4):689-699. PMID: 21178287
• Robinson RA, Lange MB, Sultana R, Galvan V, Fombonne J, Gorostiza O, Zhang J, Warrier G, Cai J, Pierce WM, Bredesen DE, Butterfield DA. Differential expression and redox proteomics analyses of an Alzheimer disease transgenic mouse model: effects of the amyloid-beta peptide of amyloid precursor protein(Xi). Neuroscience 2011;177:207-222. PMID: 21223993; PMCID: PMC3058851
• Poksay KS, Banwait S, Crippen D, Mao X, Bredesen DE, Rao RV. The Small Chaperone Protein p23 and Its Cleaved Product p19 in Cellular Stress. J Mol Neurosci 2011;9574-9577. PMID: 21691801; PMCID: PMC3246043
• Zhang J, Rao RV, Spilman P, Mangada J, Xie L, Vitelli C, Gorostiza OF, Madden DT, Zeng X, Jin K, Hart MJ, Bredesen DE, Galvan V. Endogenously EGFP-Labeled Mouse Embryonic Stem Cells. Aging Dis 2011;2:18-29. PMID: 21874159; PMCID: PMC3160738
• Madden DT, Davila-Kruger D, Melov S, Bredesen DE. Human Embryonic Stem Cells Express Elevated Levels of Multiple Pro-Apoptotic BCL-2 Family Members. PLoS One 2011;6, e28530, 10.1371/journal.pone.0028530 PONE-D-11-19250. PMID: 22174832; PMCID: PMC3235131
• Libeu CP, Poksay K., John V, Bredesen DE. Structural and Functional Alterations in Amyloid-B Precursor Protein Induced by Amyloid-B Peptides, J Alzheimers Dis 2011;25:547-566. PMID: 21471643; PMCID: PMC4001850
• Rao R, Patent A, Zhang Q, Flores S, Bredesen DE. Cellular effects of APOE4: Implications for Alzheimer's disease. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 2011;7:S569.
• Libeu CP, Descamps O, Zhang J, John V, Bredesen DE. Altering APP proteolysis: increasing sAPPalpha by targeting dimerization of the APP ectodomain. PLoS One. 2012;7(6):e40027. doi: 10.1371/journal.pone.0040027. PMID: 22768208; PMCID: PMC3386930
• Choi SW, GA, Ng R, Flynn JM, Melov S, Danielson SR, Gibson BW, Nicholls DG, Bredesen DE, Brand MD. No consistent bioenergetic defects in presynaptic nerve terminals isolated from mouse models of Alzheimer's disease. Journal of Neuroscience 2012;32(47):16775-16784. doi: 10.1523/JNEUROSCI.2414-12.2012. PMID: 3175831; PMCID: PMC3736741
• Rao R, Descamps O, John V, Bredesen DE. Ayurvedic medicinal plants for Alzheimer's disease: a review. Alzheimers Res Ther 2012 Jun 29;4(3):22. doi: 10.1186/alzrt125. PMID: 22747839; PMCID: PMC3506936
• Rodríguez Plaza JG, Villalón Rojas A, Herrera S, Garza-Ramos G, Torres Larios A, Amero C, Zarraga Granados G, Gutiérrez Aguilar M, Lara Ortiz MT, Polanco Gonzalez C, Uribe Carvajal S, Coria R, Peña Díaz A, Bredesen DE, Castro-Obregon S, Del Rio G. Correction: Moonlighting peptides with emerging function. PLoS One 2013;8(10). doi: 10.1371/annotation/fc687f18-ce8e-4704.... eCollection 2013. PMID: 24194802; PMCID: PMC3806584
• Sultana R, Robinson RA, Lange MB, Fiorini A, Galvan V, Fombonne J, Baker A, Gorostiza O, Zhang J, Cai J, Pierce WM, Bredesen DE, Butterfield DA. Do proteomics analyses provide insights into reduced oxidative stress in the brain of an Alzheimer disease transgenic mouse model with an M631L amyloid precursor protein substitution and thereby the importance of amyloid-beta-resident methionine 35 in Alzheimer disease pathogenesis? Antioxid Redox Signal 2012;17(11):1507-1514. PMID: 22500616; PMCID: PMC3448937
• Poksay KS, Banwait S, Crippen D, Mao X, Bredesen DE, Rao RV. The small chaperone protein p23 and its cleaved product p19 in cellular stress. J Mol Neurosci 2012;46(2): 303-314. doi: 10.1007/s12031-011-9574-7. PMID: 21691801; PMCID: PMC3246043
• Bredesen DE, John V. Next generation therapeutics for Alzheimer's disease. EMBO Mol Med 2013;5(6):795-798. doi: 10.1002/emmm.201202307. PMID: 23703924; PMCID: PMC3779441
• Descamps O, Spilman P, Zhang Q, Libeu CP, Poksay K, Gorostiza O, Campagna J, Jagodzinska B, Bredesen DE, John V. AbetaPP-Selective BACE Inhibitors (ASBI): Novel Class of Therapeutic Agents for Alzheimer's Disease. J Alzheimers Dis 2013;37(2):343-355. doi: 10.3233/JAD-130578. PMID: 23948888; PMCID: PMC3971881
• Zhang J, Spilman P, Chen S, Gorostiza O, Matalis A, Niazi K, Bredesen DE, Rao RV. The small co-chaperone p23 overexpressing transgenic mouse. J Neurosci Methods 2013;202(2):190-194. doi: 10.1016/j.jneumeth.2012.09.022. PMID: 23022695; PMCID: PMC3562756
• Theendakara V, Patent A, Peters-Libeu C, Philpot B, Flores S, Descamps O, Poksay K, Zhang Q, Cailing G, Hart M, John V, Rao R, Bredesen D. Neuroprotective sirtuin ratio reversed by ApoE4. PNAS 2013;110(45):18303-18308. doi: 10.1073/pnas.1314145110. PMID: 24145446; PMCID: PMC3831497
• Spilman P, Descamps O, Gorostiza O, Peters-Libeu C, Poksay K, Matalis A, Patent A, Rao R, John V, Bredesen D. The multi-functional drug tropisetron binds APP and normalizes cognition in a murine Alzheimer's model. Brain Research 2014;1551:25-44. Issue Cover. doi:10.1016/j.brainres.2013.12.029. PMID: 24389031; PMCID: PMC4001856 [Available on 2015/3/10]
• Zhang Q, Descamps O, Hart MJ, Poksay K, Spilman P, Kane D, Gorostiza O, John V, Bredesen DE. Paradoxical Effect of TrkA Inhibition in Alzheimer's Disease Models. J Alzheimers Dis 2014;40(3):605-617. PMID: 24531152; PMCID: PMC4091737
• Galluzzi L, Kroemer G, Bredesen DE, et. al. Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death Differ 2015;22(1):58-73. PMID: 25236395; PMCID: PMC4262782
• Bredesen DE. Reversal of cognitive decline: A novel therapeutic program. Aging 2014;6(9):707-717. PMID: 25324467; PMCID: PMC4221920
• Zhang Q, Du G, John V, Kapahi P, Bredesen DE. Alzheimer's Model Develops Early ADHD Syndrome. Journal of Alzheimer's Disease, 2014 May. (Submitted)
Chapters
• Bredesen DE. (2010) BACE, APP Processing, and Signal Transduction in Alzheimer's Disease. John, V. (ed.), BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease. John Wiley & Sons, Inc., Hoboken, NJ, pp. 1-14.
• Bredesen DE. Role of Programmed Cell Death in Neurodegenerative Disease. Reed, J.C. and Green, D. (eds.), Apoptosis: Physiology and Pathology of Cell Death. Cambridge University Press, New York.
• Bredesen DE. Prionic Loops, Anti-Prions, and Dependence Receptors in Neurodegeneration, Prusiner Beitrag 2013.
• Jagust W, Bredesen DE, Campisi JC, Lithgow G, Vijg J. Molecular and Cellular Biology of Aging (2013) in press.

[Elizabeth (Alaska) · Rating 5 out of 5]

I picked up this book a few years back and let it languish on my virtual shelves. I did not think then (nor do I now) that I'm headed for Alzheimer's, but the idea that that dreadful disease could be prevented or reversed was marvelous and I wanted to know more about it.

I have become aware that my memory isn't as good as it once was, but not awful. Some days are better than others. From this book I can self diagnose early subjective cognitive impairment. I very occasionally have to search for a word and other things. I know clearly that on those days when I am even somewhat sleep deprived, I could easily tape a sign to my forehead "I am stupid". I can look back to some of those days and understand why some nights I have trouble either getting to sleep or waking for 2-3 hours in the middle of the night. A lack of exercise and a lack of good nutrition will take their toll.

This is the first stage of decline. The second stage is called mild cognitive impairment (example given was a woman who had trouble remembering which was the correct freeway off-ramp) and then finally Alzheimer's. Bredesen tells us that Alzheimer's is not a single disease and that there are three main aspects: inflammatory, suboptimal levels of nutrients and other synapse-supporting molecules, and toxic exposures. That stuff we've always learned about sticky amyloid substances comes from a natural and necessary brain process run amok.

Bredesen recommends a whole host of medical tests, including the normal blood tests with which most of us are familiar. Not everyone arrives at dementia or Alzheimer's by the same path. I guess as varied as is the human species, we should not be surprised at that. Bredesen developed a program to help us both prevent and reverse dementia. But we need to start early because the longer we allow ourselves to decline the harder it is to get well.

Bredesen's program is much more than about getting a good night's sleep. Inflammation, for example, can come from several sources, even as simple as needing to see the dentist. With the "American diet" few of us are actually getting the full complement of needed nutrients regularly. Toxicity is harder for me to pinpoint, but it could be as simple as air pollution for those who live in cities or more difficult to identify if from household mold.

There is a lot of science in this book. Success has been accomplished by many who have followed the program. I admit that some of it went over my head. In other places I stopped to do a quick Google check and get some of the terms presented somewhat differently. Because it is so dense and because I felt that much of it didn't apply, I might be tempted to give this only 4-stars. But the entire conclusion is too important to slight it. And besides, I think I might find myself rereading.

[Rosemary Ward · Rating 5 out of 5]

Before summarizing Dr. Bredesen’s matchless research on treatment protocols for aggressive cognitive decline, I need to recap where we stand as a country in the face of this disease, which threatens the stability of our medical systems, our communities, and our family units.

We all know someone who has survived cancer, but no one knows a single person who has survived Alzheimer’s. There is no treatment for it. After a diagnosis, there is a clear message conveyed – You are not going to get better. This is the beginning of the end. It will probably be awful.

In America, only two medications are currently prescribed to “slow the decline of neural degeneration”. (Everything else offered is a knock-out pill of one kind or another.) If you know someone in the throes of neural degeneration, you also know that slowing things down and prolonging the exquisite decimation of this human being’s neural real estate, is no blessing.

No new Alzheimer’s drug has been approved since 2003. That’s 15 years of nothing. We are making great strides in cancer and in molecular biology, generally. Meanwhile, death by dementia is rapidly increasing. It robs victims of their humanity – sometimes over decades – it terrorizes and bankrupts their families, and we have no effective treatment. What? While the technology industry makes startling advances in Artificial Intelligence almost weekly, we have stood by and watched the human intelligence of our seniors wither away appallingly. This situation seems ghoulish to me.

You have likely heard neuro-specialists parroting the amyloid plaque hypothesis. In fact, only those toeing the amyloid line can get funding for their research. Meanwhile, amyloid plaque is also found in the brains of perfectly healthy individuals. Amyloid is only one piece of a very complicated puzzle. Scientists and doctors investigating the root causes of cognitive decline and braving the icy waters of non-amyloid based research are mostly ignored.

In this book, Dr. Bredesen addresses the other pieces of the dementia puzzle and lays out his protocol, which has helped many hundreds of people reverse their cognitive decline.

This book is 70% understandable to the average reader (like me) and 30% rather technical and sciencey. There were two chapters I had to read twice and, yes, I took notes. His protocol is rooted in lots of common sense but there are many supplements he recommends, after the patient has had extensive blood work done so that there is a detailed, personalized blueprint of the patient’s overall metabolic flexibility (or lack thereof). He connects his reader with support groups (which I have visited) where extensive help is offered in determining your cognitive health – his calls this a “cognoscopy”.

My best take-aways:

1. Exercise almost every day. Sweat. Make it count. 30 to 45 minutes. This stimulates BDNF (brain-derived neurotrophic factor) which supports new neuron growth.
2. Stop eating sugar. It is poison for neurons.
3. Protect your sleep. 7 to 8 hours of quality sleep is imperative.
4. Vitamin D3!!! Take it. (Or, be outside in the sun without sunblock every day, if possible. No, not for hours. No, don’t let yourself fry.)
5. Fresh, organic vegetables with every single meal, and lots of them.
6. Lots of good fat – coconut oil, avocados, fatty fish (like salmon), nuts, and grass fed beef or chicken, but in small servings
7. Eliminate gluten.
8. Get your BMI in a good range.
9. Exercise your brain by challenging yourself, move around throughout the day, and get out and socialize.

The supplementation he recommends is rather extensive and it is keyed to your health blueprint. You need to follow through on extensive bloodwork in order to know exactly how much inflammation your body (hence your brain) is dealing with and where you stand with insulin sensitivity. These two things – inflammation and insulin senstitivity – are dire enemies of cognitive health. And environmental toxins….he spends plenty of time talking about this, too.

He urges those with cognitive decline to try to maintain a mild state of ketosis by eating lots of fat, some protein, but very little carbs. This makes the brain use fat as its main source of energy, which optimizes cognitive health. This is a widely-accepted practice and many people without any cognitive decline at all eat a ketogenic diet for better performance in life.

Dr. Bredesen’s entire program is called ReCODE (Reversing Cognitive Decline). His results, which he details in the book, have been astounding. I have personally joined some of the online groups using his protocol – it is the real deal. It does not look easy. It looks like a big commitment. It looks like work.

In chatting with one of my kids about this, he said: “Well, easy choices – hard life. Hard choices – easy life. Right?” Right….

If someone you love is battling cognitive decline, read this book. Take action. Take control of the situation for him or her. Do all that you can. Do not wait for a new drug because anything new is going to be targeting only ONE of the many things which cause cognitive decline. You want a solution with addresses the whole mess.

[Becky · Rating 3 out of 5]

Have utmost respect for Dr. Bredesen and the research he has done. I am thrilled that there is a method to address Alzheimer’s but in my opinion this book is too difficult to understand, making the program unwieldy for most people. I appreciate that he uses analogies to express difficult topics and that not everyone wants to understand the details. But, the list of tests that he recommends is very confusing - there is no clear list that I can take to my physician to request these tests. The reader has to discern the actual test name from with in the text.

I believe that in order to follow the ReCode protocol I would need the help of my doctor to order the tests and understand the results. Unfortunately I don’t see that happening, I wouldn’t know what to ask my primary care physician for and I expect she might dismiss my interest. Since I don’t currently have any symptoms and don’t have the ApoE4 variant, it will be difficult for me to take any specific actions without some guidance.

I certainly hope that more doctors and practioners read this book and make the approach more mainstream. That is what is needed for this to take hold and help so many people in need.

[Ms. Reader · Rating 5 out of 5]

I received this book from Goodreads First Reads in exchange for an honest review...

A very important and powerful book, that is a huge eye-opener. Strongly recommend everyone reading it, even if you don't know anyone personally who suffers from Alzheimer's.

[Repix Pix · Rating 1 out of 5]

Indecente usar los sentimientos así.

[Frederick Gault · Rating 5 out of 5]

There is a lot of good common sense life-style advice that everyone should do. EG: exercise, don’t smoke, get your BMI to a good place, eat less meat and more veggies, reduce stress, reduce sugar, etc. Just THAT would improve the lives of most people. I thought his model with 36 different routes to the APP Protease enzyme snipping in a blastic vs clastic mode was explained well and was backed up by hard science. I do kind of understand why the FDA balks at a multi-modal clinical regime in the typical 3 phase trial, there are just so many variables based on epidemiology that it is difficult to say with absolute certainty what mechanisms are in play. That being said, how DOES one test his hypothesis? I suspect that his book is based on his pique at being shot down by the Australian equivalent of the FDA. In time, clinical data will have to be teased out of studies that are not conducted in the 3 phase approval model. My friend a PhD microbiologist will tell you that it is only worth testing one mechanism at a time . . . I’ve had arguments with him about this . . . why not collect data without complete mechanistic understanding?

I like the idea of checking hormones, glucose, vitamins, heavy metals and tailoring a treatment schedule. It is just a more comprehensive process than what your typical clinician (i.e. Insurance Company death panel) will approve. Where I have to start disagreeing is his advocacy of so many herbal remedies. The science behind and purity of that stuff is suspect. The right thing to do would be to set up double-blind studies of each product with purity assays and prove that they do something positive. Naturally, that ain’t gonna happen anytime soon. Big Pharma can’t make money off supplements so they won’t finance the studies and the providers of supplements don’t need to do the studies, even if they can afford to, because their market doesn't insist on this kind of data.

That means I think the process is solid, the supplements, more suspect. I think my wife and I are going to try and find one of these practitioners and go through the blood work/treatment model . . . the herbs I may reserve judgement. Two exceptions on the supplements; Resveratrol and Curcumin have SOME good studies that seem to support their usage. Vitamins are in-between with their use subject to blood work that shows you really need them. Vitamins are subject to hype and can be harmful. The data available for vitamin C seems to support it not doing anything unless you have scurvy.

[Natali · Rating 5 out of 5]

I picked this up for extra research for a project I was working on and I am so glad that I did! If this doesn't inspire you to a healthier lifestyle, I just don't know what will! This doctor's research is fascinating and refreshingly holistic. It is very east-meets-west - western medicine meets eastern healing. I hope that this catches on so that we can arm people with the tools to avoid this painful disease, which has claimed two of grandparents' lives.

The doctor introduces the word "dementogens," which is like a "carcinogen" for brain health. It refers to things that lead to cognitive decline such as a diet full of gluten and sugar, high exposure to toxins, chronic inflammation, and head trauma. These are things we have a measure of control over. I do encourage reading this book so that you can commit to the best health that you possibly can and help reverse any cognitive decline you may be suffering in your own family.

[kimera · Rating 5 out of 5]

Deep bows and respects

[Robert Luebke · Rating 5 out of 5]

This is a must read for anyone who fears the threat of getting Alzheimer's. Dr. Bredesen is a neurologist and researcher who lays out a plan called RECODE for preventing and even reversing some of the symptoms of Alzheimers. Nutrition plays a big role in his program, but the stories of patients who have improved from Dementia after being on this program is very promising.

[Carol Bakker · Rating 4 out of 5]

I have SO much to write about this book, but no time.

For so long, type 2 diabetes was framed as an incurable, progressive disease. We now know that it is a metabolic disease the responds beautifully to dietary changes to lower insulin. Similarly (but with far more complexity) Alzheimer's disease responds to lifestyle changes and supplements.

This is a book of hope, and if dementia is part of your family history I highly recommend giving it a read. A few chapters almost swamped me with the science, but there are many many many good ideas. It's complicated: not one disease, but three. Not monotherapy (the one pill that fixes all) but a multilevel approach.

My principle for any therapy/change is: If it can't hurt, why not see if it helps? For example, dental hygiene is a risk factor. Oil pulling (swishing coconut oil in mouth for three minutes) sounds woo-woo, but it can't hurt and may help.

No time, but there I just wrote three paragraphs!

[Bailey · Rating 3 out of 5]

This is certainly an intriguing protocol, and after almost a decade it would do well with an updated edition with follow-up data from the “hundreds” of patients purporting to be utilizing the shotgun approach of Dr Bredesen’s treatment regimens.

I think overall, the focus on lifestyle adjustments will be beneficial for cognitive function for ALL of us, but medically reversing Alzheimer’s remains to be seen.

[Payal Sachdeva · Rating 5 out of 5]

Read this awesome book ..Alzheimer’s disease (AD) has become part of the zeitgeist. Millions are devoured by this draconian disease and once one gets sucked into the blackhole of AD, the life becomes grim, doomed and there is unrelenting descent into a mental abyss and decline , depriving the human from its very identity; emotionally, mentally and physically. It affects not only the patient but even the family and caretakers .
Earlier it was considered to be the disease of old age but as said rightly , diseases don’t follow the books , AD has started affecting the people as young as 40, all thanks to sedentary lifestyle , high sugar and carbohydrate diet, diabetes , stress , lack of sleep and exercise .

Dr Bredesen is the professor of neurology at the university of California , and he has been working on AD for decades and he explained beautifully how humans get AD and ways to keep it at bay .

As thought earlier that AD results due to accumulation of amyloid beta plaques in the brain , leading to mental confusion, MCI And SCI ( mild and subjective cognitive impairment) but it is not so , amyloid has been vilified for the decades Like cholesterol , infact both are important for the body . This disease occurs just like diabetes , hypertension, cancer , obesity and can be prevented or treated just by incorporating simple lifestyle modifications.

Readers who have read Jason Fung’s , obesity code and diabetes code , would love reading this book.

The worst part is ,this disease starts insidiously and it takes atleast 8-10 years to manifest the full blown Decline , and people tend to hide the symptoms , considering them as part of the aging , stress , fuzzy senior moments. Anyone above 40 should follow simple regimen to keep this at bay .

This book gives the reader a multi pronged approach , yet simple , to prevent this disease and I found the content pertinent. The discussion flouts decades of conventional wisdom , that it cannot be avoided and treated . Time to unlearn this dogmatic assertions .
I highly recommend this book.
I have read Fung’s , obesity code, diabetes code, cancer code , the complete guide to fasting , life in the fasting lane ; Gary Taubes good calories , bad calories … what is common in all the books is the importance of intermittent fasting and sleep.

AD occurs due to consumption of sugar and processed carbohydrates, dairy , lack of sleep and exercise , all leading to rise in insulin , leading to insulin resistance and brain atrophy . There are various ways to diagnose this disease , simple being MRI and PET scan .

Lack of deep sleep for 8-9 hours is the major culprit for diabetes , cancer and AD, as sleep induces ketosis, which helps in overall well being of human body and mind .

Dale has made some appendices as what should be done and what not to eat ; mainly stressing on intermittent fasting , avoiding sugars and carbs , one hour daily walk or exercise , avoiding dairy , use of probiotics and few supplements, good dental hygiene and flossing , and the most important being good uninterrupted sleep of 8-9 hours .

This disease can affect anyone of us but the people who have genetic risk factors have ten fold increase to acquire this disease . No one is impervious to it , so Time to take care of our health .

People who read daily our less likely to develop AD, as neurons are always active so less chance of neuron death 😊

[Leah · Rating 2 out of 5]

Author is Chief Science Officer this company https://www.apollohealthco.com/ which sells a ReCODE program that costs $75/month without labs. Conflict of interest that absolutely needed to be addressed in this book.

Lots of recommendations, little citations. Let alone peer-reviewed ones.

Lacks of any form of clinical trial whatsoever.

Claims to cure Alzheimer's but writes that the program is more effective for people who are pre-Alzheimer's - "If you have moderate Alzheimer's, improvement is unfortunately more difficult."

Science part was okay, not explained the best (i.e. the author used the word "autophagy" with absolutely no explanation given- no one knows what this means except biologists!!!) Frequent analogies to cancer were not useful.

A lot of the vitamin/herb claims were pulled out of no where. No science behind these, and if there is, it was not explained at all. Overall, this book just tells you to live a healthy lifestyle, which almost everyone knows they should be doing. The main novel part of this book is the use of the ketogenic diet, which I really wasn't even convinced of. Is it the 15 hour fast that induces ketosis and autophagy necessary - is the high fat diet required? Reasons given in the book for necessity of ketogenic diet seem to deal with insulin signaling and glucose levels. However, if you are not diabetic, I think that a whole plant food diet consisting of healthy carbs would be fine. As there is no controlled trial on this, there is no way to know if ketogenic diet is required on top of the 15 hour fast.

There are people who this program has worked for, evidently. So I'll give it 3 stars. Will be interesting to see if this holds up overtime and what changes are made to this protocol.

[Designlover · Rating 5 out of 5]

EXCELLENT

Great follow to his first book published in 2017.
That book and working with a Function Medicine M.D. who trained with Dr Bredesen,
I have followed the Protocol now for 3 years with terrific results:
No more “Senior Moments”
At 76, Great Confidence in my physical Health and mental acuity going Forward.
Look up his CV :
Cal Tech undergrad with honors,
M.D. from Duke,
Research with Dr. Stanley Prusiner, who received the Nobel Prize in Medicine for Brain Research.
Founded the Buck Institute for Aging Research (had a Lab there for many years)
Set up The UCLA Easton Center for Alzheimer’s Research
. . . . and more . . .
Check out the many interviews with him on YouTube

[Ann · Rating 5 out of 5]

Please read this book.
If you, or anyone you care about, suffers from any form of cognitive decline — or even if you or a loved one has a family history of cognitive decline — I implore you to read about Bredesen's ReCode protocol.

Personally dealing with a loved-one's cognitive decline, I have seen the traditional approach's lack of support, hope, or help. As Bredesen says, the traditional approach is pretty much, "there's nothing that can be done." But, Bredesen outlines why this is no longer true. He details the science behind his approach to reversing cognitive decline (yes, not just halting, but reversing!). But he also includes case studies and personal stories for those of us without medical degrees.

For my very non-medical summary: the basis of Bredesen's approach is that there is not one sole cause of cognitive decline. Therefore, it cannot be reversed with one drug (at least, not at this time). Cognitive decline is caused by a number of factors that, when there are enough of them, tilt the scales too far to the wrong side. Once this happens, the brain produces more of the cognitive decline causing amyloid. And, the more amyloid the brain produces, the more decline it creates... which causes the brain to produce more amyloid. It's a downward spiral — unless you can chip away at those amyloid-creating factors and tip the scales back in your brain's favor. Which, as Bredesen details, can be done.

Do you have to read and understand the few technical chapters in the book? No. But I found them incredibly helpful to understanding the reasons behind the protocol outlined in the rest of the book. So, I would suggest you not be daunted by the technical chapters. I set aside plenty of time to read, reread, (and reread again if necessary) each paragraph so that I was sure I was understanding — to the best of my ability — what is actually happening within the brain. Again, you don't have to read these chapters to understand the rest of the book, but I think taking the time to digest the science made it easier to understand the protocol.

While my loved-one has not yet completed the entirety of the Bredesen protocol, I have seen the positive effects of aspects of this protocol first-hand. There is truth in this book. There is hope.

Please, please, please read and share this book and this approach, with yourself, your loved ones, and your doctors.

[Molly Ferguson · Rating 5 out of 5]

This book really changed the way I think about cognitive decline and what can be done to address it. I want to put it in the hands of several people in my life who may be resistant to it. It's clear, easy to read (he even tells you which are the two jargon-filled chapters and gives you permission to skip them), yet science-based. I especially appreciated that the book is full of 1.) examples from people's lives, and 2.) exactly what you need to do to follow the ReCODE system. Here's the thing: some of the parts of the system I already do, and other parts are *really* hard for me to follow--I will need to do a lot of changing of my lifestyle to follow them. For example, I do sleep well and exercise, but no way in hell do I (or do I want to) do the 12 hour ketosis period. I've always felt the keto diet was disordered eating, but this book might have changed that for me--it has a pretty good argument for why you should be in mild ketosis before you eat your first meal. There are other things that I feel like I can incorporate into my lifestyle with just a little effort, like brain games and reducing blue light and limiting dairy/gluten. If I start experiencing decline, I really think my first line of defense would be following this strictly, at least to try it. If you know anyone having difficulty with memory and focus or who has the APO4 gene, maybe direct them to this book!

[Jim Angstadt · Rating 4 out of 5]

The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline
Dale Bredesen

If you or someone you know has Alzheimer's then this book can be a very worthwhile read. Roughly the first half of the book is devoted to a medical and research understanding of the symptoms and causes. There is a lot of science here. For example, the Food and Drug Administration rejected a proposed drug trial because it didn't fit the notion of one drug to fix one problem. As the author points out, Alzheimer's has many problems and medications; the interaction of each can vary between individuals.

The second half of the book is much easier to understand and follow, but be warned. The recomended treatment will require major changes to one's medications, diet, exercise, and maybe sleeping patterns.

[Joan · Rating 3 out of 5]

I would like to have seen some actual day-to-day meal planning of what one can eat on this diet. That may just be me who needs something more concrete. What does a breakfast, lunch, snack, and dinner look like? The science was all well and good but the practical side of me needed more detail on the foods and meal planning.

[Lora Taber · Rating 4 out of 5]

Interesting and informative with accessible science-based explanations to accompany the suggestions for diet changes, supplements and lifestyle modifications. One thing this is lacking are convenient tables/lists to refer to for specific supplement recommendations.