He's not wrong, probably. So let me explain my rating.
I came to this book by way of Dr. Rhonda Patrick, who expressed some reservations about the overall tone but in favor of the last section on prevention. (It's about the last 40 of 160 pages, the rest is all footnotes, index, etc.)
I have read many similar "panic" books in the past. Some that I think were right that never got much attention (Women and the Crisis In Sex Hormones springs to mind), and then there are some that had an outsized effect, like Silent Spring, frequently cited by Trasande. But then he'll name drop Rudolf Steiner in the same breath and well...huh. I mean, I'm not against out-of-the-box thinking: I presume we're drastically wrong in what we collectively believe or, you know, things would be a lot better than they are (if that makes sense). But when you pull in a bunch of names with little explanation, I get the sense I'm supposed to know who they are and agree with their ideas. I don't (know them), and if I did, I wouldn't necessarily agree.
The effect here is kind of desultory. I'm not sure how the people you're referencing bear upon the topic at hand—and the topic at hand is overwhelming enough. I docked a star for this.
The topic, as near as I can tell, is the danger of endocrine disrupting chemicals (EDCs) in our environment. We get a scattershot look at the science, with one really significant (and perhaps hard to grasp) point: The effects of some of these chemicals may not scale linearly. A little may hurt more than a lot. Also, a tiny exposure may doom your great-grandchildren.
These early ambiguities—everything is "may", "might" or "could", which is to be expected of an honest book—are punctuated by examples from Trasande's practice which almost certainly aren't. They're used because they're similar to what may, might or could be caused by what he's talking about. I docked a star for this, too. It's a formulaic trope of these kinds of books meant to humanize the issues, as if issues of cancer and fertility and pediatric illness needed any extra humanizing.
Trasande's big on regulation early on in the book. And he frequently cites industry-backed studies with a tone of "these are suspicious". Suspicion is good. Then he goes on to cite, admiringly, how they're using tactics the IPCC is using to bolster the climate change case. But of course the IPCC knows how all its tests are supposed to come out in advance. He cites The Lancet, which published the link between MMR and autism. It really doesn't matter whether you believe there's a link between MMR and autisim or not: Either way, they published, then retracted—they were (or are) wrong. And that's just one of many non-reproducible studies.
What I'm getting at is that the imprimatur of industry no more (and no less) taints results than the imprimatur of any establishment organization, even if it styles itself "non-profit". And regulation is a severe danger here: Consider that, per Trasande, a lot of us may have had our first major exposure to EDCs from fire-retardant chemicals in pajamas mandated by the state of California.
I had to dock a star for this kind of "We've got to regulate!" You get the absurdity of BPA being banned for some uses, only to be replaced by chemical dopplegangers BPF, BPS and so on. There's a potentially harmless, mildly more expensive chemical used for the same purpose (to minimize bacterial growth on the inside of cans, I believe is the purpose), but maybe it's not harmless and maybe corporations will fight to save 2 cents on a can of soda, rather than just jacking up the price a nickel.
By the end, he expresses the (IMO) correct idea that education is the best weapon here. But it's hard to educate when you don't know yourself what's going on. And yes, you'll have to fight a lot of disinformation, though I don't think it's as bad as it is in areas like vaccines and climate change because there isn't nearly as much money involved, and even the evil corporations would prefer to have a product they can sell without killing their customers or being sued by them.
The monetary breakdown to me was odd and seemed to be aimed at...I dunno, policymakers? I don't care if it saves (or costs!) $100 billion, if it means I don't get cancer and my kids can have healthy kids. But I guess that's a thing for...someone.
The statistics felt dubious to me, as well. At one point, when he brings in air pollution, he talks about the dangers of coal burning. Well, great, there's a risk that's known and mitigable (by improving the handling of the waste) versus a less measurable "how many people will die from heat/cold because power's too expensive?" which doesn't get a mention. There are always unseen costs—and Trasande does not always factor those in, preferring large-scale "it costs us $X billion" versus "this will increase the cost to you by ¢Y". (More on individual versus group impacts later.)
I'm out of stars to dock, but the prevention stuff was disappointing. Yeah, you can eat organic food, you can eliminate your exposure to certain chemicals, you can change your whole life (and spend a lot more money, regardless of the idea that "it's getting cheaper because Amazon bought Whole Foods") and you still may not actually get it right. One of the examples used made the situation worse because one item used to wean them off their plastic lifestyle was actually highly tainted.
Oy. I think this review is getting longer than the source material.
This book reminds me a bit of Dr. Hulda Clark's Cure For All Diseases/Cancers/etc, in that you can't help but come away feeling under constant assault by the environment. (Dr. Clark was convinced that it wasn't just chemicals but also microorganisms, and the unholy mixture of the two, that were source of our woes.) But she had designed a testing device you could build yourself on the cheap, so at least you knew if you were doing the right thing (by her theory).
Dr. Clark, of course, was considered a quack but it's interesting how many of her ideas a resurfacing 30 years later under more "establishment" umbrellas.
Point is, the book leaves you with a bunch of rituals that may or may not work. You might find they produce a dramatic change in you, in which case God bless. I used Dr. Clark's "zapper" to cure my allergies. (Might've been a complete placebo effect but you know what? I don't have any allergies so I don't care.) Maybe you cut down your exposure to all the bad plastics and you don't need your BP medicine any more, or maybe nothing changes, and you don't know if it's because nothing was wrong in the first place or you didn't actually do what you thought you did.
If the book had focused more tightly on what an individual could do, and how to know whether or not he'd done it, and what the positive impacts should be, it would've been a lot more useful—and I think it would have been more powerful, because a group of people who had personally experienced health improvements would be a lot more effective in mobilizing against these things.