Michael Crichton revisited the world of genetic engineering in his novel _Next_. Steering away from recreating extinct organisms (namely dinosaurs, as in his _Jurassic Park_ novels), he looked at issues of genetic engineering as well as how the legal world and the culture relates to it, issues that are relevant today. Some parts are scary, though more in a sickening death-and-taxes-that-could-really-happen kind of way than an edge-of-your-seat-oh-my-goodness kind of way.
Lots to dissect in this book; let's look at the two main plots to begin with. One plot revolved around the saga of Henry Kendall, a genetic researcher who years ago mixed his own DNA into chimpanzee DNA. He thought the fetus - as most transgenic fetuses ended up being - would either die in the womb or otherwise die soon afterwards and he would have something for a research project. Owing to a series of events he lost track of the mother, the mother gave birth, and the transgenic animal - the humanzee - survived. Harry, who left the lab, assumed the animal had died but was given a heads up by a former colleague that his humanzee, dubbed Dave, was going to be euthanasized. Bad enough to put down an animal (that was after all the result of an illegal experiment), it got worse; Dave is sentient and can speak. Harry basically smuggled the animal out of the lab and did his best to keep him safe and then give him some kind of life.
The other main plot revolved around a both chilling and perhaps insane saga. It seems a man by the name of Frank Burnett had cancer and underwent some experimental treatment. Frank recovered, but not thanks to the researchers. It turned out that Frank's own body could manufacture powerful cancer-fighting components, and those components were valuable. Without informing Frank what was going on, his doctor/genetic engineering entrepreneur Rick Diehl was obtaining numerous samples from Frank, developing a cell line in the lab for genetic research and later commercial purposes, and building an entire profitable company around this.
This being the day and age it is Frank sues of course. Why can't he get a cut of the immense profits? Don't they at least need his permission? Incredibly, in court Frank, represented by his daughter Alison lost. The company, BioGen, it is ruled owned those cells. Any cells that Frank lost during the hospital are considered waste material and he lost ownership rights to him, and when Rick patented his findings from studying those cells, Frank lost any chance to ever make any profit from that cell line.
Frank was about to give up and go home after losing the court case when an unscrupulous and shady character comes up with a proposal; what if BioGen were to "accidentally" lose all of those cell lines in their labs and off-site storage facilities? If Frank went into hiding, another, second company could come, extract cells from him and this time cut Frank in for a share of the profits.
Well Frank of course agrees, but that is where it gets interesting. Faced with a devastating financial blow, Rick and BioGen need those cell lines. They get a court order for Frank to show up and give more samples - after all, BioGen "owns" Frank's cells - but he is a no show. However, they know that Frank has a daughter and a grandson, and they go after them, hoping to extract cells from them, viewing those cells as "stolen property." Easily the most action-packed of the plotlines, it was quite entertaining.
Crichton does not limit his exploration of the world of genetic engineering, culture, and the law, to these two story lines and has several unrelated or marginally related subplots and one-shot chapters exploring various other issues, including issues relating to patenting entire species of wild animals, when hospitals make a profit from the body parts of deceased patients, and the rights of anonymous sperm donors in a world of DNA testing. Though generally interesting, they didn't always relate to what I viewed as the two main plots and one of these plot lines was better as an intellectual exercise and didn't do much as entertaining fiction.
I found that the book ended a bit too neatly in some ways, as too many seemingly unrelated plotlines converged at the end, including one with a wise-cracking transgenic parrot by the name of Gerard. The writing though overall was good and I liked how he portrayed most of the characters.
Unusually for a work of fiction, Crichton included a list of conclusions he reached from his research for the book. An appendix detailed five suggestions to avoid some of the insanity he had just portrayed, namely stop patenting genes (that one he went into at length), establish clear guidelines for the use of human tissue (particularly with regards to donor rights), pass laws to make sure data about genetic testing is made public (he stated that some researchers have tried to prevent data about patient deaths resulting from genetic therapy getting into the public media, claiming such information is a trade secret), avoid bans on research (he wrote that they can't be enforced anyway), and rescind the 1980 Bayh-Dole Act (legislation which ended up seriously blurring the line between academic research and private industry and producing too many scientists motivated by personal financial interests in their research and results). He also included an extensive bibliography with comments on each book or article.