Geroscience is the field of inquiry dedicated to studying how we age, what causes us to age, and how we can reduce the corrosive effects of aging.
Aging is not a disease, rather a natural process. People don’t die of old
age; they die of biological processes that break down.
• Genetics is responsible for between 25 percent and 33 percent of the
variance in life expectancy.
A delightful read on how the brain functions (there's still a lot to unravel) & tips on reducing the corrosive effects of ageing:
As you peruse these pages, you’ll discover what geroscientists already know.You’ll learn how to improve your memory, why you should hang on to yourfriends for dear life—literally—and why you should go dancing with them asoften as possible. You’ll discover why reading a book several hours a day canactually add years to your life. You’ll find that learning a new language may bethe best thing for your mind, especially if you’re worried about dementia. Andthat regularly engaging in friendly arguments with people who disagree with youis like taking a daily brain vitamin. You’ll also learn why certain video gamescan actually improve your ability to solve problems.
We’ve got it relatively good. For virtually our species’ entire history, human
life expectancy was about thirty years. Life expectancy is the benchmark for
what’s typical. And it has been steadily rising. Were you living in England in
1850, you generally died in your mid-forties. That figure is four decades longer
now. If you were an American in 1900, you died around age forty-nine. It was
seventy-six by 1997.
Not true anymore. Americans born in 2015 can expect to live to seventyeight
(it’s a little more for women, a little less for men). If you’ve already made
it to your sixty-fifth birthday, you can expect to live nearly twenty-four more
years if female and nearly twenty-two more years if male. That’s an astonishing
10 percent jump since the year 2000, and the numbers are expected to go even
higher.
In this view, longevity is the amount of time you could spend on the planet
were conditions ideal. Life expectancy is the amount of time you likely will
spend on the planet, given that conditions are almost never ideal. It’s the
difference between how long you can live versus how long you will live.
So how long can humans live? The oldest person with an independently
You probably learned in high school that brains are strung together with
electrically active nerve cells—neurons—but you may have forgotten what they
looked like
Impossibly complex
branching structures, called dendrites, exist at one end of a typical cell. Those
dendrites gather together into a trunk-like structure termed an axon. Unlike our
maple’s trunk, however, there is a bulge at this point of gathering. It’s an
important swelling—called the cell body—and its reputation derives from a
small spherical shape inside it. This is the nucleus of the neuron. It houses the
cell’s command and control structures, the double-ladder-shaped molecule DNA.
Axons can be short and squatty, like our maple’s trunk, or long and slender
like a pine tree’s trunk. Many are wrapped in a type of “bark” that’s called white
matter. At the other end of the axon lies a root system, just like a plant’s,
consisting of branching structures termed telodendria. These usually aren’t as
complex as the dendrites, but they serve an important information-transfer
function, as we’re about to see.
The brain’s information system runs on electricity, like most light bulbs, and
their shape helps them do it. To understand how, imagine pulling one of our
Japanese maples out by its roots, and then, while my wife has a heart attack,
holding it over the top of our other maple. Don’t let them touch. The root system
of the top tree is now hovering over the branches of the bottom.
Now imagine these two trees are neurons. The telodendria (roots) of the
upper neuron lie close to the dendrites (branches) of the lower cell. In the real
world of the brain, electricity flows from the dendrites of the top neuron down
its axon and arriving at the telodendria, where it immediately encounters the
space between the two. The gap must be jumped if information is to be
transferred. This junction is called a synapse, and the space it creates, the
synaptic cleft. How to pole-vault the space?
The solution lies at the tips of those root-like telodendria. There are small
bead-like packets at those tips containing some of the most famous molecules in
all of neuroscience. They’re called neurotransmitters. I’ll bet you’ve heard of
some of them: dopamine, glutamate, serotonin.
When an electrical signal reaches the telodendria of one neuron, some of
these biochemical celebrities are released into the synaptic cleft. It’s the
equivalent of saying, “I need to send a message to the other side.” The
neurotransmitters dutifully sail across the gulf. It’s not a long journey; most of
these spaces are only about 20 nanometers in length. Once the neurotransmitters
have crossed, they bind to receptors on the dendrites of the other neuron, like a
boat tying up to a dock. This binding is sensed by the cell, alerting it with signal
that says: “Oh, I better do something.” In many cases, that “do something”
means becoming electrically excited too. It then passes along this excitement
down the chain from dendrites to axons to its telodendria.
While jumping the space between two neurons using biochemicals is a neat
trick, the electrical circuits aren’t usually this simple. If you can imagine lining
up thousands of cellular Japanese maples root-to-branch, you’d have something
approximating an elementary neural circuit in the brain. And even that’s too
simple. The typical number of connections a single neuron makes with other
neurons is around seven thousand. (That’s only an average: some have more
than a hundred thousand!)
The major culprit in aging is a hot topic. Some scientists speculate about
immune system deficiency (the immunologic theory). Others blame
dysfunctional energy systems (the free radical hypothesis; mitochondrial theory).
Others point to systemic inflammation. Who is correct? The answer is all of
them. Or none of them. Each hypothesis has been found to explain only certain
aspects of aging
The frontal lobe is also responsible for helping you predict the consequences
of your own actions. It helps you suppress socially inappropriate behaviors and
even make comparative decisions. For many reasons, these are important regions
to keep fat and happy.
The amygdala, a little almond-shaped nodule dangling just behind each ear,
is involved in processing your emotions. It too is affected by levels of social
activity. The higher the overall number of (and the greater the variability in) the
types of relationships you maintain, the bigger your amygdala becomes. These
aren’t small changes.
You can create an environment conducive to quality relationships. Social
psychologist Rebecca Adams summarized how in a New York Times interview a
few years back, if you cultivate the following:
• “repeated, unplanned interactions,” spontaneously rubbing shoulders with
good friends
• “proximity,” living close by to friends and family members so those
shoulders are available for rubbing
• “a setting that encourages people to let their guard down”
As people get older, they suffer an increasing inability to recognize familiar
faces, and they lose their perception of some of the emotional information those
faces carry. We even know the reason. The neural tracts—the white-matter
cabling—connecting the fusiform gyrus to other regions of the brain begin to
lose structural integrity. Prosopagnosia illustrates an important principle in the
brain sciences: specific regions of the brain exert a dictatorship over specific
functions. When those regions become injured, those functions can be altered—
or disappear.
The type of dance didn’t seem to matter. Tango, jazz, salsa, folk, various
kinds of ballroom dancing: all exerted their whirling wizardry on the brain.
Further research has shown that other forms of ritualized movement instruction,
such as tai chi and various martial arts, also show benefits in many of these same
measures.
• Keep social groups vibrant and healthy; this actually boosts your
cognitive abilities as you age.
• Stress-reducing, high-quality relationships, such as a good marriage, are
particularly helpful for longevity.
• Cultivate relationships with younger generations. They help reduce
stress, anxiety, and depression.
• Loneliness is the greatest risk factor for depression for the elderly.
Excessive loneliness can cause brain damage.
• Dance, dance, dance. Benefits include exercise, social interactivity, and
an increase in cognitive abilities.
Cortisol has an important brain region in its gunsights: the hippocampus.
This sea-horse-shaped brain region is famous for being involved in learning. It
has custodial rights over the formation of certain memories, such as that bears
are real threats.
The problem with modern society is that you can be caught in stressful
situations that last for years—say, a bad marriage or a bad job—the
physiological equivalent of the grizzly bear moving in with you. I mentioned
brain damage. Indeed, exposure to unrelenting long-term stress can lead to major
depression and anxiety disorders, which are true collapses of multiple brain
systems.
Another primary target of cortisol’s aggression is the prefrontal cortex
(PFC), that vital brain region involved in planning, working memory, and
personality development. Prolonged stress destroys the dendrites and spines of
specific nerve cells (called pyramidal cells) within discrete layers of the PFC,
trashing their connections. It’s a massacre.
Mindfulness, put simply, is a series of contemplative exercises that gently
and nonjudgmentally ask you to focus your brain on the now rather than on the
past or future. Kabat-Zinn puts it this way: “Mindfulness means paying attention
in a particular way; on purpose, in the present moment, and nonjudgmentally.”
The training exercises have two large components. The first is awareness of
the present. Mindfulness invites you to pay attention to the intimate details of
whatever is happening at this moment, excluding all else.
The second component is acceptance. Mindfulness entreats you to observe
your present-moment experiences without judging them. It’s a method of asking
you to observe your life without getting into a quarrel with it.
Put bluntly, mindfulness calms you down. This has all sorts of behavioral
consequences. Seniors who practice mindfulness sleep better than those who do
not, for example, probably because of lowered cortisol levels. Mindful seniors
show marked reductions in depression and anxiety. They report ruminating less
frequently over negative things. People who practice mindfulness don’t feel as
lonely, either, and describe sometimes dramatic changes in the amount and
quality of happiness they experience daily.
Strive to be positive about aging. If you feel young, your cognitive
abilities improve.
• Practicing mindfulness consisting of contemplative exercises that ask
you to focus your brain on the present, rather than the past or future,
can both reduce stress and boost cognition.
Each system is in charge of processing a specific type of memory, each
composed of freelancing neural circuits working in a semi-independent fashion.
As an example, suppose you remember a high school shop class where your
friend Jack got cut while you were all learning how to use a lathe. Learning how
to operate a lathe prior to the accident involved a specific memory domain
(motor). Recalling that the person who got cut is named Jack and not Brian uses
another domain of memory (declarative). Recalling that you watched it in time
and space—morning shop class—complete with a cast of characters, you and
Jack, uses still another memory domain (episodic).
These systems talk to one another constantly, integrating and updating their
findings in tiny fractions of seconds. Yet how they do this is mostly unknown.
Episodic memory, that lively, previously mentioned subdivision of
declarative memory, is just what it sounds like. It is a memory for episodes, the
information about events occurring in a certain context and—this is important—
interacting through time. Casts of characters are usually interacting in these
events. If the character happens to be you, we call it autobiographical episodic
memory. Episodic memory is in charge of answering questions like “what,
where, and when”—standard fare in a typical This Is Your Life installment.
Episodic memory marries two components: the information being retrieved
and the context in which the information is recalled. The former is probably just
good old semantic memory—the memory for facts. But the latter is unique to
episodic memory and gets its own name: “source memory.” Think of it like a
person giving a speech. Semantic memory recalls the content of the speech.
Source memory remembers who said it.
Working memory, for example, peaks at age twenty-five for most people,
stays steady until thirty-five, then begins its long slow journey into the night.
A smattering of other habits, sounding like Pope John Paul’s daily to-do list,
reveals more memory-boosting treasure. Exercise (mountain climbing with the
Daredevil, anyone?) is great for both short-and long-term forms of memory. So
is meditating. The usual my-parents-already-told-me lifestyle habits apply here,
too, like getting enough sleep, eating healthy foods, and hanging around good
people. Plus something your parents didn’t know to tell you: staying away from
the blue light of electronic devices.
Every day you exercise your brain above what you do typically delays that
deterioration by 0.18 years.
Fluid intelligence, roughly defined, is your ability to persuade your problemsolving
talents to come out and play. Specifically, it’s the facility to apprehend,
process, and solve unique problems independent of your personal experience
with them. As one research paper noted, fluid intelligence involves our “abilities
to flexibly generate, transform, and manipulate new information.”
Since information needs to be held in a volatile memory buffer, at least while
you’re manipulating it, you might predict that working memory plays some role
in the ability. Lab findings would show you’re right. Fluid intelligence is highly
correlated with working memory ability. They may, in fact, influence each other.
And we’ve already seen that working memory takes a dive with age.
Fluid intelligence is often contrasted with its talented twin, crystallized
intelligence. Crystallized intelligence is defined as the ability to draw from
material learned by experience, using information previously stored in a
structured database. As you’ll recall, not all memory systems erode with age
(some improve), and you see this statistically with crystallized intelligence.
Depending on how you measure it, crystallized intelligence stays fairly stable
throughout life
Dementia with Lewy bodies
Williams’s diagnosis wasn’t uncommon. Lewy body dementia is the secondleading
cause of dementia in the United States, accounting for between 15
percent and 35 percent of all dementias, depending on the study. It’s named after
the German scientist Frederic (Fritz) Lewy, who first noticed tiny dark dots
around the neurons of people who had died from “senility.” We now know those
clumps are abnormal knots of the protein alpha-synuclein. The symptoms they
cause include sleep disturbances, motor imbalances, memory losses, visual
hallucinations, and then Alzheimer’s-like behavior. We don’t know why the
knots cause dementia; we don’t know how to treat it; we don’t even know how
people get it. In recognition of our ignorance, we call the disease’s origin
“idiopathic,” a term over which Robin Williams probably would have cracked
up.
Parkinson’s disease
The second dementia is one not famous for being a dementia at all.
Parkinson’s disease is most notorious for causing people to lose motor control—
arms flailing, legs refusing to follow gaiting instructions. Famous sufferers
include Michael J. Fox, Muhammad Ali, and Billy Graham. It’s named for
James Parkinson, a nineteenth-century British physician, who originally called it
“Shaking Palsy.”
That was a good name but also a tad incomplete. Although Parkinson’s is a
movement disorder, later stages almost always include dementia, cognitive
disorders like changes in ability to focus, or affective disorders like depression
and anxiety. Parkinson’s disease occurs when brain cells in specific regions start
dying off, like those in the substantia nigra (in the lower middle of your brain).
No one knows why this cellular genocide occurs, though it may be related to a
familiar villain—alpha-synuclein. Indeed, people with Parkinson’s often have
Lewy-like bodies hanging around their dying nerves.
Frontotemporal dementia
The third disease comes early. Frontotemporal dementia typically strikes
younger people (around age sixty, though it can even hit twenty-year-olds).
Language deficits are a symptom, but the biggie is a striking change in
personality. You see wildly inappropriate behavior, such as shouting at
strangers, hitting people, gorging on food, and exhibiting a marked indifference
to loved ones. Frontotemporal dementia also can include repetitive behaviors,
such as talking about the same subject over and over again, continually mowing
the lawn, or walking the same path repetitively. It is neurodegenerative, with
progressive damage to the frontal lobes (the regions behind your forehead) and
temporal lobes (the ones next to your ears). No one knows why it occurs.
Then you have the vascular dementias, which cause cognitive mayhem the
same way strokes do, by leaking small amounts of blood into the brain. There’s
Huntington’s disease, the same dementia that claimed Woody Guthrie. There’s
even one that may be communicable, Creutzfeldt-Jakob disease, mediated by a
particle called a prion. Fortunately, it is among the rarest of the group.
President Reagan would not slip his mortal coil for another ten years. The
average is four to eight years, which is why Alzheimer’s is sometimes called the
Long Goodbye. This is no ordinary aging, however. For people living with
Alzheimer’s at age seventy, about 60 percent will be dead before age eighty. For
people without Alzheimer’s, only 30 percent will be dead by age eighty. Thus
Alzheimer’s roughly doubles the risk of death. It’s the sixth leading cause of
death in the United States, regardless of age.
that figure is expected to triple by 2050.