Over three years ago, Professor Luisa Villareal, along with Detectives Ryan Kelly and Sarah Choo, as well as Officer Antonio Guerrera, thwarted a madman's scheme to recreate Shakespeare's most famous murders against a series of victims to enact a terrible revenge. They thought that was the end of it. One morning in July, three years later, however, Villareal receives a video message. That same madman, Christian Patterson, is back. Not only is he back, but he has taken Villareal's younger sister captive and holds her at an undisclosed location. Given only forty-two hours, Villareal must solve a series of clues taking her to different locations in New York City associated with William Shakespeare. If she can do it in time, she will save her sister. If not... Before long, Kelly, Choo, and now-Detective Guerrera are back on the case. While Villareal, Kelly, and Choo try to solve the clues, Guerrera frantically hunts the city for Patterson himself. And all the while, the clock is ticking...