If you're expecting this book to be like Listening to Ayahuasca, prepare to be disappointed. This book could have been condensed to approximately thirty pages of valuable info, all of which is expressed better on the MDMA subreddit or Erowid. This book is mainly a memoir about the author's experience growing up in the 50s, being a young man during the counterculture of the 60s, then falling into the perpetual Boomer naval-gazing. It's not that his story of radicalism in the 60s is uninteresting, but it isn't unique. In fact, white male Jews dominate the genre, so Winger would really have to stand out. And he's an average radical. So, you're better off spending your time reading Allen Ginsberg, Bill Ayers, or Abbie Hoffman, who are far more interesting characters.
The useful info is in the chapter eight "A Guide to the Responsible Recreational Use of MDMA." You'll find the same, and more detailed info on the subreddit for this drug. The author disavows the responsibility of telling you if there's any scientific reason to follow his supplementation regime, simply stating it feels right for him and the people he knows. I don't think it's a bad regime, but I do think it's lazy writing not to try to determine the validity (the man supposedly has tons of academic friends and yet he can't just ask somebody to ask a friend?). They may be wrong, I have no scientific basis to assess, but at least the Reddit anon will try to explain the science to you. I expect that in a monograph.
Worse, Winger's drug elitism is pervasive and passes without any second guessing. He divides the world into good drugs (drugs he likes: MDMA, cannabis, psychedelics, alcohol in moderation) and bad drugs (drugs he doesn't like: amphetamine, there's a general anti-ketamine vibe, all opioids in all but the most dire circumstances, and especially cocaine, which he had an unhealthy relationship with and still struggles to avoid). Winger acts like the last A in MDMA doesn't stand for amphetamine. He encourages people who realize they've aged that they can learn self-management strategies to come back to MDMA from earlier problematic use, but yet he can't apply that logic to his own former problematic substances.
This book succeeds in being unique as the story of a man and his wife getting into rave culture late in life. If you're looking for that, and plenty of reassurance you can get horny, do drugs, and dance well into your 70s, then you've come to the right place. I was not looking for this, but I did find his reflection on his changing subjective experience of drug use and sexuality in older age as a philosophy of generally seizing life to be inspiring. It was wrapped in so much self-indulgence, though, that I have a hard time feeling like this is a book to recommend. Winger labors the same points over and over and even retreads parts of the same anecdotes. He's like my charming psychedelic grandpa retelling the same stories over and over; but I came to hear an expert's tightly delivered lecture.