One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents. Series Editor "The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."
David A. Frank, a professor of rhetoric at the University of Oregon, has published on rhetorical theory, argumentation, and the Israeli-Palestinian conflict. He is the corecipient of the 2002 Kohrs-Campbell prize for rhetorical criticism and received the article of the year award from the Religious Communication Association in 2003.