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The Immunity Fix: Strengthen Your Immune System, Fight Off Infections, Reverse Chronic Disease and Live a Healthier Life

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The Immunity Fix is a comprehensive guide to how the immune system works, how different viruses and infections affect our health, and offers strategies that have been shown to enhance the immune system. It includes the most up-to-date scientific information about the most important factors related to staying healthy during viral outbreaks as well as in everyday life. There’s also practical tips and tools that improve stress resilience, speed of recovery, metabolic health, cardiovascular function and quality of life. Here are the topics discussed in the * Lessons From Past Pandemics * Fundamentals of the Immune System and Immunosenescence * Immunity and What's the Link? * Magnesium Deficiency and Immunodeficiencies * How an Overactive Immune System Drives Chronic Inflammation and Autoimmune Diseases * COVID-19 and an Overactive Immune System * Insulin Resistance and Immunity * Balancing Our Omega 6/3 Ratio to Calm an Overactive Immune System * Hot and Cold Therapy to Prime the Immune System * Eating for a Healthy Immune System * The Power of Nutrients and Nutraceuticals for Boosting Immunity * Intermittent Fasting, Autophagy, and Immunosenescence * Exercise and Immunity * Sleep, Circadian Rhythms, and the Immune System Compared to other books about the same topic, The Immunity Fix takes an objective view of the pros and cons of every known intervention and lays out the most research-backed protocols to follow. This book will teach you how to support your immune system, what to do when you actually get sick, and how to improve your overall health and vitality. As a cardiovascular research scientist and doctor of pharmacy, Dr. James J. DiNicolantonio has spent years researching nutrition. A well-respected and internationally known scientist and expert on health and nutrition, he has contributed extensively to health policy and medical literature. Dr. DiNicolantonio is the author of 3 best-selling health books, The Salt Fix, Superfuel and The Longevity Solution. Siim Land is an author, speaker, content creator, and renown biohacker from Estonia. Despite his young age, he is considered one of the top people in the biohacking and health optimization community. Siim Land has written books like Metabolic Autophagy and Stronger by Stress.

383 pages, Kindle Edition

Published November 8, 2020

225 people are currently reading
729 people want to read

About the author

James DiNicolantonio

57 books144 followers

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Displaying 1 - 17 of 17 reviews
Profile Image for Dawn .
1 review
January 22, 2021
3.5- Valuable info, however very difficult to get through if you don’t have a strong science/ background in healthcare. Would love a version of this book written in more layman’s terminology.
Profile Image for Amanda.
192 reviews
August 20, 2021
This book is a MUST READ for everyone, especially while navigating a pandemic. Regardless of your opinions/decisions surrounding current treatments/prevention for viruses, this book will teach you how to care for your body and support your immune system which is crucial for everyone. From explaining how the immune system works, to giving advice for nutrition, supplements, exercise, and sleep improvement, this book is a helpful tool that I will likely be referring back to on a regular basis. (Don't let the length be intimidating - the final 180 pages are all references.)
Profile Image for Denis Romanovsky.
215 reviews
October 4, 2021
Excellent holistic book on the human immunity. A lot of science involved. Average level of depth, but quite good reasoning and comprehensive explanation. Highly recommended!
Profile Image for Quratulain.
714 reviews11 followers
October 1, 2025
“Optimize sleep; fix metabolic syndrome; eat a nutrient dense diet; supplement to fix your nutrient deficiencies; forest bathing; regular exercise; hot/cold hormesis; intermittent fasting
6am Cortisol levels increases to wake you up; 7am melatonin production stops; 10am mental alertness peaks; 2:30 pm beat motor coordination; 3:30pm fastest reaction time; 5pm best CV efficiency and muscle strength; 7pm highest blood pressure and body temperature; 9pm melatonin productions begins to prepare body for sleep; 10pm bowel movements suppressed: 2am deepest sleep; 4am lowest body temperature
Leptin is an adipokine that regulates energy balance, expenditure, and immune function. Leptin is a satiety hormone which is secreted from fat cells when they have enough energy and signals the brain to stop eating.
Prolonged ketosis and carbohydrate restriction may also create physiological insulin resistance. This kind of insulin resistance is not linked to any pathology and is reversible. They weren’t diabetic but had just underadapted to burning glucose and they were burning fat instead.”
Under harsh metabolic conditions like fasting, low carb or exercise, insulin resistance helps to give the brain glucose that would otherwise be taken up by muscles.”
For optimal insulin sensitivity and glucose tolerance, it is better to practice ketosis cyclically, so the body doesn’t lose its ability to utilize carbohydrates.”
Lose weight and decrease visceral adiposity.
Calories do matter but you can’t ignore the other dynamic variables that are based on the individual.”
Consuming gluconeogenic amino acids like glutamine and methionine doesn’t increase gluconeogenesis by themselves.”
Eating at night may inhibit insulin production because of melatonin binding to insulin receptors and blocking their release, thus keeping your blood sugar elevated for longer.”
Exercise before eating. Exercise during the day.
The underlying mechanism of autoimmune reactions is defective elimination of self-reactive lymphocytes, like B cells, T cells, and NK cells.”
Gluten, grains, nightshade, lectins, dairy, sugar etc—> autoimmunity
Cross-reactive foods- milk, coffee, corn, rice, millet,
T1D is associated with low microbiota diversity.
Dysbiosis or an imbalance in the microfauna controls inflammatory bowel disease.”
Low levels of vitamin D are associated with the development of autoimmune diseases.”
Low sunlight exposure: T1D. CD4+ T lymphocytes become pathological and auto-reactive, damaging health tissue. Same is found in multiple sclerosis.”
Regular moderate exercise both aerobic and anaerobic can be effective for lowering HMGB1 as well as stimulating preconditioning hormesis which can attenuate damage from future exposure because body has gotten more resilient.”
The biggest contributors to cancer are deemed to be smoking, alcohol, obesity, bad diet, lack of exercise, and aging.”
Usually your body burns fatty acids via oxidative phosphorylation pathway and switches over to glycogen at anerobic intensities . Malignancies use anerobic glycolysis- less efficient.
When tumor cells have fewer MHC I molecules than usual, they can evade detection.
Inflammation- take more MAGNESIUM and SELENIUM
Beta-glucans protect against infections, improve tumor clearance, and improve effectiveness of vaccines.
By 1600, the Native American populations fell by 99% in the Caribbean and 50-95% across the Americas by 1650.”
Vitamin D, UV light from the sun, fresh oxygen have anti-viral and anti-bacterial properties and they bolster the immune system.”
Open air has sterilizing activity on even the smallest size viral particles.”
Lactate or lactic acid, increases tumor cell proliferation and reducing lactate levels may help with cancer.”
Lower blood glucose in late-stage cancer patients is correlated with better health outcomes•
Personal Fat Threshold Theory (2015): once you exceed your limit of storing subcutaneous fat, you’ll direct the excess calories into visceral fat which contributes to the development of insulin resistance and metabolic disease.”
Elevated levels of FFA and triglycerides in the blood are linked with insulin resistance as well.”
The randle cycle (glucose fatty acid cycle) is a metabolic process where glucose and fatty acids compete for oxidation.”
Eat whole food carbs separately from fat.
Prevent cellular senescence and remove zombie cells: FOXO protein activation (48hr fast, acute exercise, heat stress, BHB ketone body)
Magnesium deficiency increases the risk of oxidative damage to DNA.”
Intermittent fasting mimics the longevity effects of calorie restriction.”
You don’t have to fast as long to get the benefits if you also recently exercised.”
Chronically activated autophagy is not a good thing: too much exercise, fasting or other autophagy boosters.
A 2-3 day fast every 2-3 months may reset the immune system, helping to get rid of old and/or dysfunctional immune cells and replacing them with healthy ones.”
What nutrients you feed to your gut bugs may determine your own health outcomes during infections. Restricting glucose intake can be protective against endotoxemia.”
Inhibiting glucose utilization was lethal during viral influenza infection.”
Grains, fats, and oils and sugars and sweeteners make up the majority of the diet in the United States.”
Magnesium: pumpkin seeds, sesame seeds, Brazil nuts,
Salt: hydrochloric acid, hypochlorous acid, taurine, chloramine.”
Saltwater solution: 1/2 teaspoon per 3.5oz water.
Speleotherapy; halotherapy
Fermented foods like sauerkraut and kombucha have b vitamins and increase NAD+. Fermentation process produces NADH and lactate which regenerates NAD+.
Ketogenic diet promotes NAD+ by fatty acid oxidation and glucose depletion.”
Fasting and calorie restriction increase NAD+ and SIRT1 levels.”
Almost all of the pathologies of COVID-19 result from depleted NAD+.
May make infections worse: NSAIDs , multivitamins, echinacea, cough medications
The most bioavailable source of vitamin D is the Sun.”
Vitamin D deficiency plus Increased Vitamin A can lead to accumulation of endogenous retinoids, triggering viral activation and promoting susceptibility to novel influenza strains.”
If you eat meat, some organ meats or eggs, then you do not need to supplement with vitamin A.”
UV radiation and riboflavin (B2) damages DNA/RNA of Viruses, bacteria and pathogens, reducing their replication.”
Active form of Vitamin B6 is needed for function of DAO Diamine oxidase- enzyme that breaks down histamine.”
Sirtuins detect cellular energy balance and modulate circadian epigenome.”
UV light in the morning activates a gene p53 which upregulates the gene encoding POMC.
Start blocking out blue light at least 2 -3 hours before going to bed by dimming down the lights and using blue light blockers.”
Methylation maintains function of immune cells like T-cells and activates the immune response. Improper methylation linked to autoimmune conditions.”
Those with MTHFR mutations, especially MTHFR 677 TT genotype, may benefit from around 1.6mg of riboflavin B2 per day.”
Lack of fermented foods in the diet has been shown to cause a fal in innate immune response.”
Supplementing with glycine may be one strategy to potentially reduce the harms of LPS and intestinal endotoxemia. Glycine can prevent high sugar and high fat diet induced NAFLD. Dose: 5grams 3-4x per day
Combat endotoxin: raw carrots, coconut oil, dandelion root, garlic and Allicin, carrageenan, short-chain fatty acids, ginger extract, activated charcoal, salt water, glycine.
Tests for endotoxemia: zonulin levels, lactulose to mannitol ratio, intestinal antigenic screenings.
By exposing yourself to more extreme temperatures you are better at tolerating them in the future.”
Heat exposure improves insulin sensitivity by increasing the expression of a glucose transporter called GLUT4. This enables faster clearance of glucose from the blood stream and directs it to muscle cells.”
Exposure to high temperatures up regulates heat-shock proteins.
Optimal sauna frequency: 15-30min session at 156F-212F, 2-4x per week.”
25%-30% decrease in POP levels in fat tissue and blood by heat-induced sweating.”
Post-workout cold exposure might block the muscle building signal and adaptations to resistance training.”
In 1962, the American Heart Association started to recommend replacing animals fats with vegetable oils because they have less saturated fat and lower cholesterol.”
All PUFA are easily oxidized when exposed to heat, light, oxygen, and pressure.”
All your cells are made of fats you eat. Dietary fats makes up all your cell membranes and will directly affect their functioning. If you eat oxidized fat they will get stored in your cell membrane and begin to cause chronic low-grace inflammation.
The cell membranes go through lipid peroxidation when exposed to the sun’s UV light—> sunburn.
Patients with PVD(peripheral vascular disease) have inflamed fat stores with deficient DHA-derived compounds.”
Instead of increasing your linoleic acid consumption, it is better to focus on lowering inflammation that is oxidizing your current linoleic acid stores.”
Oxidation of LDL cholesterol by free radicals is associated with an increased risk of CVD.”
Intake of canned seafood (tuna, sardines, salmon) should be limited as high heat is used in the canning process and can oxidize them PUFA and cholesterol.“
Combining glycine with 25 grams of glucose lowers the blood sugar response by >50%. Dose: 3-5 grams 1-3x per day.”
Natural sunset: 600-700nm.
Direct sunlight has 32,000-130,000 lux.
Half-life of caffeine is 5.7hours.
8am-9am peak cortisol levels
CYP1A2 is main liver enzyme that breaks down caffeine.
Best time to exercise is 2pm-5pm.
Stop hard physical activities after 6-7pm or at least 4 hours before bed.”
Sodium restriction increases nighttime adrenaline levels and impairs sleep.
Sodium restriction activates the sympathetic nervous system and raises aldosterone, which promotes oxidative stress and cortisol.”
Keep your phone on airplane mode when not using it.
Dimmer switches are a source of dirty electricity.”
Grounding: maintains body’s negative electrical potential similar to the Schuman Resonance. Less oxidative stress and inflammation.
Regular exercise stimulates immunity by activating Nuclear Factor Erythroid 2-related factor 2 (NRF2). Moderate exercise elevates IL-6 (anti-inflammatory).
Moderate intensity exercise less than 60mins in protective.”
A higher protein intake is more important when doing intermittent fasting or while eating at a calorie deficit to compensate for the increased catabolism.”
2.2g/kg protein
A higher HRV means you are more recovered, less stressed, and parasympathetic dominant.”
Increase HRV: exercise, intermittent fasting, heat exposure, meditation,biofeedback, music therapy
Lower HRV: emotional turmoil, hyperglycemia and insulin resistance; high inflammation; sleep deprivation
Profile Image for Anya.
301 reviews1 follower
March 24, 2023
This is a terrible book.
I have a degree in biochemistry (specialising in immunology), a PhD in molecular cancer, I am a qualified medical doctor with a specialisation in cellular pathology and in my non professional life have an obsession with holistic lifestyle improvements so I feel qualified to offer judgement on this book.
In fact I read it for that reason (noticing online that fellow yoga practitioners were reading it), I was interested in what lay people are reading from a YouTuber (and pharmacologist) writing a book about immunity.
It lists reams and reams of molecular interactions and lists of how the immune system works (but gets basic things wrong like how and why the thymus involutes with age), it offers countless studies in cell lines and mice and equated it directly with how human physiology works (step too far) and basically in term of assisting people with lifestyle choices only serves as a stress inducer in my opinion.
The strong point is the first chapter which illustrates previous pandemic in history, interesting for people who don’t know about this.
If the message is eat well (whole foods), sleep well, exercise regularly, decrease stress and enjoy a sauna or cold water if you enjoy that, then I think the format of this book is far from motivational. (My take is that probably causes people to gets extra stressed about how their immune system is working).
If you want to learn about molecular immunology (or physiology, or medical illnesses, (all fascinating topics for sure, I love this) - better choose a text book which will definitely make it more of a coherent story.
Profile Image for Lisa Osborne.
83 reviews
January 11, 2025
Great book with a lot of easy to implement strategies for improving your immune system.

Unless you are a science or health major, be sure to have Google handy so you can look up new terminology. A checkmark against the book was all the abbreviations, I had to keep going back in the book to look up each abbreviation which was time consuming (this is already a thick book) and frustrating to reader flow.

There were some things that I said to myself "that's not happening." Like when the author suggests turning off your wi-fi each night. Maybe I'm just not in a place in my life where I can go around and turn off every source of electricity coming into the house. Someday? Who knows?

Overall though I would recommend the book as a source of encouragement to make changes for better immunity.
117 reviews4 followers
March 9, 2023
I follow the author on IG and much of this info has been mentioned there. This book just goes into much greater detail and includes the scientific backing for his findings. I would have given it a higher rating but it’s a tough read unless you have a serious interest in science and/or have completed continuing education in science and research. Much of the book is explaining his studies. There is also 100 pages of citations in very small type at the end of the book.
Profile Image for Tyler.
37 reviews
March 24, 2021
5/5. Leave all your preconceptions about immunity at the door.

James DiNicolantonio’s books are meticulously researched with a ton of take-aways. I’ve read all of his previous books (The Salt Fix, Longevity Solution, and Superfuel) and still found he explored areas he hasn’t covered before.

I listened to the audiobook and will likely purchase the hardcover to reference back in the future.

Highly recommended.
19 reviews3 followers
February 16, 2021
One of the best books I have read, as a physician, about immune health using the latest data available. Dr. DiNicolantonio shares a number of references that support reversing chronic disease and advice on strengthening your immune system.
Profile Image for Cole.
101 reviews1 follower
November 17, 2021
A very good book with plenty of good advice for how to improve your immune system and general well-being.
Very science heavy in parts and if you're not entirely au fait with biochemistry, these parts may go over your head. A good job is done explaining each process for the layman though.
Profile Image for Nicole.
590 reviews1 follower
December 24, 2021
So many good and informative nuggets of info here. And most effective are the things we’ve heard all of our lives: get good sleep, eat fruits and veggies, get enough exercise, and get outdoors. We can be healthy if we are intentional about how we live!
1 review
Read
February 16, 2021
Fantastic book

Well written. Great studies sited. Take control of our immune system with tangible tips! I'm so glad I read this!
Profile Image for Carolyn.
95 reviews1 follower
August 13, 2021
Listened on audible- wish it came with a pdf.
Profile Image for Jessica Cox.
1 review
August 29, 2021
Not for those without science backgrounds. But it was very interesting for me since I have a background in science.
Profile Image for Christy Hild Noll.
44 reviews
September 5, 2021
Lots of great info here! It would definitely help if you had a science background for parts of it but there is still a lot that the rest of us can implement into our daily lives.
Profile Image for David N Ford.
58 reviews
February 1, 2022
This wasn't bad. Again I have to question some of the science behind his suppositions. But he presents the argument in a concise and straightforward manner that is easy to understand.
Profile Image for Rustam Eybatov.
33 reviews2 followers
July 5, 2024
1️⃣ Lifestyle is a key for strong immunity
2️⃣ Fasting can be beneficial, but not during sickness
3️⃣ Sleep is a fundament
Displaying 1 - 17 of 17 reviews

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