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The assistant of a small-town midwestern doctor, young Martin Arrowsmith is fascinated with the contents of Gray’s Anatomy. Eager to pursue an adventurous career in medicine and science, he eventually sets off for medical school, where he hopes to dedicate himself to research. But as Martin progresses through life, he encounters qualities in humans more troublesome than any of the specimens he examines under a microscope.
Happiness almost eludes him until his mentor offers him a post at a prestigious institute—which soon sends Martin to a plague ravaged Caribbean island. There he must show what he is truly made of.
A perennial favorite of medical students to this day, Arrowsmith won author Sinclair Lewis the Pulitzer Prize in 1926, which he declined.
417 pages, Kindle Edition
First published January 1, 1925
"Con la misma atención y exactamente del mismo modo impersonal que habría observado cómo un conejillo de indias infectado desarrollaba progresivamente la enfermedad, Martin se observaba a sí mismo, en la locura del exceso de trabajo, encaminándose hacia la neurastenia. Investigó con considerable interés los síntomas de este mal, viendo que se daban en él uno tras otro, y continuó sin cambiar de conducta, asumiendo el riesgo despreocupadamente."


I wish to acknowledge your choice of my novel Arrowsmith for the Pulitzer Prize. That prize I must refuse, and my refusal would be meaningless unless I explained the reasons.The New York Times reported that according to observers, the real reason was that Lewis was still upset that Main Street did not win the prize in 1921.
All prizes, like all titles, are dangerous. The seekers for prizes tend to labor not for inherent excellence but for alien rewards; they tend to write this, or timorously to avoid writing that, in order to tickle the prejudices of a haphazard committee. And the Pulitzer Prize for Novels is peculiarly objectionable because the terms of it have been constantly and grievously misrepresented.
Those terms are that the prize shall be given "for the American novel published during the year which shall best present the wholesome atmosphere of American life, and the highest standard of American manners and manhood." This phrase, if it means anything whatsoever, would appear to mean that the appraisal of the novels shall be made not according to their actual literary merit but in obedience to whatever code of Good Form may chance to be popular at the moment.