Big Nate follows the adventures and misadventures of Nate Wright, an incompetent, spirited and rebellious sixth-grader, along with his best friends, Francis and Teddy. Other characters include a variety of teachers at Public School 38. Nate hates social studies teacher Mrs. Godfrey, whom he considers his nemesis and calls her names like the school's Godzilla. Peirce also focuses on Nate's home life and friendships