This Festschrift volume in honour of Prof. E R Caianiello contains invited papers of eminent scientists who have worked in the several areas to which Prof. Caianiello has given seminal quantum field theory, foundations of quantum mechanics and maximal acceleration (Vol. 1); neural nets, general systems theory and various topics of cybernetics (Vol. 2). The wide range of topics covered shows the fruitfulness of a higher unifying perspective on seemingly diverse subjects.