This review applies to the Library of America "Poetry and Tales," which I read, somewhat masochistically, cover to cover.
The most famous pieces are unquestionably satisfying and admirable, melding high Romantic aspirations with pulpy sensationalism and making it look easy. Sometimes one is the style and the other substance, and sometimes the other way around. I will always have a place in my heart for them.
But the corpus read in its entirety is the story of a sad, troubled, lonely man's "uncongenial, unsatisfactory and ungrateful life," and even the spotlight works reveal themselves as simply the chance high points in his uneven, cynical, and frequently nerdy efforts in the tawdry magazine business. His real aspirations were to be a renowned poet - not of crowd-pleasers like "The Raven" but of wild-eyed gunk and crackpot pseudo-philosophy - and those aspirations were never achieved, as they probably never could have been.
The less you know of Poe's output and biography, the more substantial and gratifying his famous works will seem. So just stick to those, I say.