Harrison's Principles of Internal Medicine, Twenty-First Edition

by Joseph Loscalzo, Anthony Fauci, Dennis Kasper

The Voice of Clinical Reason A Doody's Core Title for 2023!
Harrison’s Principles of Internal Medicine is the world's most trusted clinical medicine text―and a superb resource for learning the art and science of clinical reasoning. Recognized by healthcare professionals worldwide as the leading authority on applied pathophysiology and clinical medicine, Harrison’s Principles of Internal Medicine provides the informational foundation you need for the best patient care possible. This new edition is fully updated with timely new chapters and essential updates across the spectrum of internal medicine. Written and edited by the world’s top experts in their respective fields, this landmark guide provides comprehensive, accurate, and essential coverage of the pathogenesis, diagnosis, and treatment of disease. Harrison’s is world-renowned as the most authoritative source • Clear, concise schemas that facilitate the generation of differential diagnoses to reason efficiently through complex real world clinical cases
• The physiologic and etiologic basis of signs and symptoms, which are covered through a wealth of unsurpassed expert guidance and linked to the disease-specific chapters that follow
• Updated clinical trial results and recommended guidelines
• Excellent and extensive visual support, including radiographs, clinical photos, schematics, and high-quality drawings
• Coverage of both therapeutic approaches and specific treatment regimens
• Practical clinical decision trees and algorithms
• Organ/system-specific sections, with clinically relevant pathophysiology and practical clinical advice on the approach to the patient, strategies towards building a differential diagnosis, outstanding clinical algorithms and diagnostic schema, a wealth of clinical images and diagrams, current clinical guidelines, and general and specific approaches to therapy Harrison’s remains the most trusted resource in a world influenced by endless sources of medical information. The most timely and comprehensive updates from the world’s top experts are featured in the 21st • Current coverage of the diagnosis and treatment of diseases, from COVID to dementia to sepsis to multiple sclerosis to lung cancer
• Updated content that reflects new approved therapeutics and new practice-changing guidelines and evidence summaries
• More than 1000 clinical, pathological, and radiographic photographs, diagnostic and therapeutic decision trees, and clear schematics and diagrams describing pathophysiologic processes
• Numerous atlases featuring curated collections of important visual aspects of diagnosis and management
• Updated and time-saving curation and synthesis of established and new medical literature and studies
• Clinically relevant coverage of disease mechanics and pathophysiology, and related therapeutic mechanisms

Genres: Medicine, Science, Textbooks

4384 pages, Hardcover

Published March 28, 2022

Reviews

[Annette Serrano G · Rating 1 out of 5]

No lo recomiendo. Causa traumas.

[HikBook]

diabetes mellitus definition, is presented

[Umesh · Rating 5 out of 5]

Best book for post graduate students

[Maryam F]

I haven't read the whole book (obviously). But it was a fundamental thing during my years in med school, and I didn't hate this particular book. Sweat or bitter, this is what it was.

[Roaa Wahab · Rating 4 out of 5]

The most important detail mentioned in this book about diabetes :

“ In the early stages of the disorder, glucose tolerance remains near-normal, despite insulin resistance, because the pancreatic beta cells compensate by increasing
insulin output (Fig. 403-7). A number of pathophysiologic mechanisms contribute to type 2 DM and their relative importance varies from individual to individual. As insulin resistance and compensatory hyperinsulinemia progress, the pancreatic islets in certain individuals are unable
to sustain the hyperinsulinemic state, manifesting as IGT, defined as elevations in postprandial glucose. A decline in insulin “

“ The precise molecular mechanism leading to insulin resistance in type 2 DM has not been elucidated.
Insulin receptor levels and tyrosine kinase activity in skeletal muscle are reduced, but these alterations are most likely secondary to hyperinsulinemia and are not a primary defect. Therefore, "postreceptor" defects in insulin-regulated phosphorylation/dephosphorylation appear to play the predominant role in insulin resistance. Abnormalities include the accumulation of lipid intermediates within skeletal myocytes, which “