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The Sjögren's Book

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Afflicting one in 83 Americans, Sjögren's is a serious and systemic autoimmune disease that, along with symptoms of extensive oral and ocular dryness, can lead to other serious complications including profound fatigue, chronic pain, major organ involvement, neuropathies and lymphoma. While there is no cure for Sjögren's, approaches exist to help manage and treat aspects of the disease, and this revised handbook offers everything readers need to understand and cope with their diagnosis.

The Sjögren's Book , Fifth Edition is a comprehensive and authoritative guide, produced by the Sjögren's Foundation and its medical advisors and edited by a leading authority on autoimmune disorders. This expanded edition provides readers with the best medical and practical information on this disease, bringing together current thinking about Sjögren's in an easily readable and understandable book and providing important new content on areas not covered in previous editions. With more than fifty chapters written by leading experts, this handbook illuminates the major clinical aspects of the disease and is loaded with practical tips and advice as well as scientific advancements in the field. Indeed, it offers a wide-ranging look at the many faces of Sjögren's, covering diagnosis, the many organ systems that can be affected, emotional burden and management, treatment options, and hope for the future.

Recognized as the bible for Sjögren's sufferers, this reliable and informative guide is the first place for patients to look when they have questions about this disabling disease. It is a valuable aid that patients can use while discussing their illness with their physician and an excellent resource for family members. Because Sjögren's is greatly underdiagnosed, this handbook is a particularly valuable resource for healthcare professionals.

544 pages, Hardcover

Published May 20, 2022

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Displaying 1 - 3 of 3 reviews
210 reviews
December 8, 2023
A wasted $22

Although supposedly a manual for patients, the doctors who wrote this kept forgetting their intended audience. This, they have created a book teeming with scientific minutiae that most readers won’t grasp. At the same time, the book will be too simplistic as a learning manual for physicians.

This book serves no one.

Exhibit A: “The cardinal symptom indicating a respiratory disorder is dyspnea. This can be challenging to tease out from the fatigue and deconditioning that can complicate Sjögren’s, but typically, the dyspnea is exacerbated by exertion for most of the obstructive and restrictive lung complications. Episodic non-exertional dyspnea would be atypical for most, but consideration should be given for asthma, thromboembolic disease, vocal cord dysfunction, or episodic arrhythmias. When dyspnea is aggravated in the supine position, this may indicate heart failure complicating pulmonary hypertension, respiratory muscle weakness, or upper airway disorders such as obstructive sleep apnea. Wheezing is characteristic of obstructive lung disease, including asthma, and is rarely a central airway problem.”


Exhibit B: The hypothesis that endometriosis may represent an autoimmune disease was first proposed in 1980. A number of immunologic dysfunctions have been reported among patients with endometriosis, such as an increased number and activation of peritoneal macrophages, high T- and B-lymphocyte counts, decreased T-cell reactivity and natural killer cell cytotoxicity, increased circulating antibodies, anti-endometrial antibodies, and changes in the cytokine network. It is unclear if the immunologic alterations induce endometriosis or if they are a consequence of the endometriosis. However, they appear to play an important role in allowing endometriosis implants to persist and progress and contribute to the development of infertility and pelvic pain.


I have a college degree. I’ve seen five children and a husband through 25 years of medical maladies. I can grasp basic-to-intermediate medical jargon. This book was beyond. Oddly, I wasn’t mad at the authors for talking down to me, because they weren’t. Rather, they were talking with each other and had completely forgotten that the reader existed. I would even try to find it endearingly geeky, had I not shelled out $22 for the kindle version. Better than spending $40+ for the hard copy.
Profile Image for Jennifer.
166 reviews36 followers
July 14, 2025
I read this book due to the issues of having this disease myself. it is so informative and a great resource. it mentions other autoimmune diseases and how many can .mimic this disease and vis versa. I also feel that reading this if you have multiple autoimmune ir immune compromise will benefit you in the long run.
I am so greatful I found this book and hope those in need will read this book.
I recommend this to everyone who is either experiencing autoimmune diseases or their caregivers
Profile Image for Erika.
23 reviews10 followers
January 14, 2024
Great information well presented

The Sjögren’s Book was so helpful to me. It was well organized, each chapter having a relatively narrow focus. I appreciated the abundance of easily accessed resources for further learning at the end of each chapter. Most importantly, after reading this book I feel less isolated in my journey, and better equipped to manage my health
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