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304 pages, Hardcover
First published April 18, 2023
Pathogenesis refers to the origins and development (Genesis) of a disease (pathos) with a particular focus on the way that pathogens infect our cells, and the effect this has on our bodies. In the pages that follow, we will explore how viruses, bacteria, and other microbes impact aggregations of bodies, that is the body politic, body economic, and body social. This is history from deep below. Rather than thousands or millions of little humans working together to change the world we will explore the role that billions or trillions of microscopic viruses and bacteria have unwittingly played in history.The following excerpt describes how recent advances in science has enabled the collection of evidence related to diseases which have occurred in the past.
Advances in DNA analysis have revolutionized our understanding of pathogens in the past. Ancient skeletons have started to reveal mind-blowing secrets and lots of them. This book pulls together this groundbreaking research, much of which has been published in paywalled scientific journals and is not widely read outside of academia. It places it in the context of research from other disciplines, including archaeology, history, anthropology, economics, and sociology.Then the author provides more specific descriptions of the times in history when microbes played a role.
Outbreaks of infectious diseases have destroyed millions of lives and decimated whole civilizations, but the devastation has created opportunities for new societies and ideas to emerge and thrive. In this way, pathogens have been the protagonists in many of the most important social, political, and economic transformations in history.As I was going through the book I experienced it as primarily a history and didn't perceive it as a story about plagues. It wasn't until the end of the book I recalled the subtitle that referred to eight plagues which made me wonder, what were those eight plagues? So I want back and rounded them up and listed them below. The word plagues is being used not as specific diseases or pandemics but rather as broad historical periods of infectious disease that shaped human civilization. (It's the same as delineated in the previous excerpt).
• The transition from a planet inhabited by multiple species of human to one in which Homo sapiens reigned supreme.
• The replacement of nomadic hunter-gatherer societies with sedentary agriculture.
• The demise of great empires of antiquity.
• The transformations of Christianity and Islam from small sects in Palestine and Hijaz to world religions.
• The shift from feudalism to capitalism.
• The devastation wrought by European colonialism.
• The Agricultural Industrial Revolutions.
• And the creation of the modern welfare state.
By the time we have finished, I hope to have changed the way you think about history, and our species' role in it. To convince you that the modern world has been shaped by microbes as much as by women and men.
• Paleolithic Plagues: Infections that occurred as early humans migrated.One criticism of the book:
• Neolithic Plagues: Diseases that emerged as humans settled and domesticated animals during the Neolithic Revolution.
• Ancient Plagues: Infections in ancient civilizations, such as the Plague of Justinian.
• Medieval Plagues: Diseases that shaped the medieval world, most notably the Black Death.
• Colonial Plagues: Infections that accompanied the colonization of the Americas.
• Revolutionary Plagues: Diseases that influenced major revolutions.
• Industrial Plagues: Infectious diseases that developed alongside industrialization.
• Plagues of Poverty: The ongoing impact of infectious disease in poverty-stricken regions.