Calories In, Calories Out is Nonsense.
I made the switch about a year ago to entirely cutting out ultra processed foods from my diet. I’m a busy dad and husband but me and my wife cook everyday and I bake several times a week. I stopped focusing on calorie counting to keep a healthy weight and instead focused on the food that is going into my body. It has made all the difference. I lost weight and my relationship to food dramatically changed. Hunger and satiety are toned down and not as strongly associated with my brain’s reward system. So it took little convincing to me to pick up Metabolical. And here’s the thrust of his arguments: ultra processed foods (UPFs) are causing fatty liver disease, metabolic syndrome, leaky gut, insulin resistance, mitochondrial oxidative stress and chronic inflammation. UPFs are slowly killing everyone.
Calorie In, Calorie Out?
Let’s do a thought experiment. For one year one person eats 3,000 calories of McDonald's food and nothing but that. That same person’s identical twin spends one year on a tropical island where they can only consume 3,000 calories of coconuts and crab legs. Does anyone really in their right mind believe that these two twins will have the same weight at the end of the year? Of course they will not. Do you think someone who only consumed 3,000 calories of alcohol would also look a little different assuming they are supplemented with vitamins? You know that’s true in an intuitive way and the author explains why in a cellular metabolic way. It is soooo much more complicated than the calorie deficit. It’s not about absolute calorie consumption, it’s about the types of food, or food-like-substances, you are putting in your body.
One of the problems is high fructose corn syrup (HFCS). It’s… not really a food, it’s an additive to food to make food addictive.Let’s back it up.
Table sugar is a disaccharide called sucrose which contains: 1 molecule of glucose and 1 molecule of fructose. It is naturally found in sugar cane and fruit. It’s also naturally very scarce. Every cell of your body can metabolize the glucose no problem, via glycolysis, to create energy and it doesn’t require oxygen to do this. Fructose, on the other hand, is primarily metabolized by the liver, something like 50-70%. Sucrose is so incredibly sweet to use because we are engineered to crave it because it is such a beautifully quick source of energy. Our cellular biology was not designed for a diet abundance in sucrose.
Here’s the thing about HFCS, it’s also a mixture of glucose and fructose and doesn’t even contain that much more fructose than sucrose. BUT, the sugars in HFCS are chemically unbound as opposed to sucrose which bonds glucose and fructose together. This unbound fructose from HFCS hits the liver like a metabolic sledgehammer as opposed to sucrose which takes longer to metabolize and gets to the liver in a more balanced manner. HFCS is also found in something like 75% of all foods in the grocery store. Why? Because it’s sweet and addictive and so the food makers make sure it is there. It’s pervasive, cheap and addicting. So HFCS is both economically available and bioavailable.
Here’s the problem: all the gut punching amounts of fructose is killing your liver. Your liver is processing most of it and here’s the kicker: unlike glucose, fructose enters liver cells without the regulation of insulin. Insulin only controls glucose cellular uptake. Not fructose. Fructose just waltzes into the liver and causes a very specific problem: hypermetabolic overload. It’s just too much energy and so your liver has to package it away somewhere and what does it do? It stores it as liver fat in a process called de novo lipogenesis (DNL). DNL creates a toxic excess of palmitate, a saturated fatty acid which spills into the rest of the body (dyslipidemia). This also causes infiltration of fat into the liver (steatosis) which is fatty liver disease. This process drives hepatic high insulin as a maladaptive attempt to keep glucose under control. The fat in the liver then drives the formation of other metabolites (DAGs and cermaides) that interfere with insulin receptor signaling within the liver cells. The liver then becomes insulin resistant. Because the liver becomes insulin resistant, it starts dumping more glucose into the rest of the body which then stimulates the pancreas to create more insulin and BAM you have peripheral insulin resistance or type 2 diabetes. This right here is the epicenter of metabolic disease. And it all starts with slamming our livers with fructose.
High insulin, or hyperinsulinemia, is bad. High serum insulin has an adverse reaction in every tissue bed. High insulin can mess with satiety in the brain and increase risk for cognitive disease like Alzheimer's. High insulin messes with blood vessels and their smooth muscle which can put you at risk for things like heart attacks and strokes. High insulin stimulates more triglycerides production which can cause heart attacks and stroke. You can get diastolic dysfunction in the heart from high insulin. Fat tissue itself responds to insulin by… storing more fat. Skeletal muscle can cause intra-muscle lipid accumulation. High insulin can cause fluid retention and high blood pressure from the kidneys. The list goes on.
Do you see how it’s all related? It’s like a terrible metabolic chain reaction nightmare that all starters with ultra processed foods. This book will make it clear for you.
Western medicine is all about treating the symptoms of western lifestyle. We focus on keeping glucose low in diabetics, which is a symptom of metabolic disease, rather than keeping insulin low by addressing the underlying metabolic disease caused by processed foods. Hospital revenue is derived from procedures, most of which are treating the end of line consequences of metabolic disease. Preventative medicine is not profitable. But do you know what is profitable? Catastrophic medicine. It’s when the diseased bodies show up that the coffers are open. Now, I’m a doctor, an anesthesiologist intensivist, and I don’t think Western medicine has done this by design from the beginning. Western medicine is simply a guild of highly educated people that are working within market-based institutions that follow the money. And the money is found in treating the symptoms of metabolic diseases.
Obesity is a symptom, not a disease. Obesity is a consequence of metabolic disease. Something like 20% of obese people don’t have metabolic disease and plenty of people think they do. Let’s reiterate: you can be obese and healthy. I have been saying this for years but I don’t have the endocrinology chops to back up my claims. Now I do. Because the author is an endocrinologist. Don’t people see that by labeling obesity as a disease it opens the pharmaceutical floodgates to profit from yet another symptom of metabolic disease without addressing the underlying cause which is (all with me now): ultra processed foods?
Don’t get me wrong, I’m all about fat-positivity and I do not believe that obesity is a moral failing. Obesity is a fallout from conspiring corporate influences to keep us addicted to harmful food products. Fortunately the new popularity of GLP-1 drugs (like Ozempic) do address the underlying metabolic derangements, much like resting high glucose with insulin, it doesn’t really address the problem of intake of ultra processed foods. It’s not like GLP-1 drugs are going to stop people from magically ingesting toxic food and they keep people reliant on an expensive pharmaceutical. Are you getting the theme? → PROFIT. But it’s even worse, this arrangement with insulin and GLP-1 dependence creates a rent seeking operation of patient’s very bodies where the food industry creates the persistent metabolic disease state and Big Pharma mitigates the fallout from the metabolic disease state. It’s perverse. The real solution is cessation of ultra processed foods which would simply fix the metabolic disease. But here’s the thing, the processed food market wants you to believe it’s all about the calorie deficit so that obesity and metabolic disease will remain a moral failing of the consumer. As long as it’s your fault and not theirs, no policy change is needed from the FDA and USDA.
Let’s discuss the gut. It needs fiber. Why? Because there are billions of bacteria down there and if they directly touch the skin of your gut, you're going to get inflammatory cells coming in to keep them in check. A fiber lining protects the gut and feeds the bacteria appropriately so they don’t have unchecked growth. Well, UPF have detergents in them, also known as emulsifiers, that break down this fiber/mucus layer, exposing your gut to chronic inflammation. Stuff like soy lecithin, polysorbates, carboxymethylcellulose, propylene glycol, DATEM, xanthan gum and many more emulsify foods, bringing water and fat soluble things together, to make them mix well, have longer shelf life and to have a smoothie more tasty quality. All of these detergents can disrupt the gut mucosal barrier and cause inflammation and translocation of bacteria and their products (like lipopolysaccharides). This is concept behind the “leaky gut” theory (not a formal diagnosis). And, spoiler, but leaky gut and chronic inflammation can also drive metabolic disease via hyperinsulin and oxidative stress (which is where too many oxygen free radicals are created for too many cellular calories that have a tendency to tear stuff apart).
Are you seeing that there is no shortage of mechanisms by which ultra-processed foods destroy your body? I’ve only gone over like three of them. There are many more. I’ll stop boring you and just tell you: read the book.
Okay, so feeling trapped? What can you do? Well, I’ll tell you what I do.
One criticism of this book I’ve seen is that the author isn’t specific about what “real food” is. My response to that is: stop playing dumb. You know exactly what real food is. If you really don’t know, there is a food processing grade created in Brazil called NOVA. Here it is:
NOVA Group
1
Unprocessed or Minimally Processed Foods
Natural foods altered slightly to make them safe or edible (washing, cutting, drying, freezing, etc.)
Fresh fruits, vegetables, eggs, milk, plain meat, rice
2
Processed Culinary Ingredients
Substances extracted from Group 1 foods or nature, used in cooking
Sugar, oil, butter, salt, honey, starch
3
Processed Foods
Foods made by combining Group 1 and 2 items; generally have 2–3 ingredients
Canned vegetables, cheeses, fresh bread, jams
4
Ultra-Processed Foods
Industrial formulations with additives, flavorings, emulsifiers; little resemblance to whole foods
Soft drinks, chips, fast food, instant noodles, packaged snacks
My advice: never eat Group 4 foods. Ever. In my home, the only Group 3 processed foods in our pantry are pasta, beans, bottled tomatoes, oatmeal. In our fridge it is mostly Group 1 and 2 with some 3, so like milk, cheese, butter, fresh veggies and condiments. Everything else we cook and bake. The only other major Group 3 processed food in our home is bread and other baked goods that we bake and process ourselves. Want ice cream? Buy an ice cream maker that takes only 4 ingredients to make vanilla ice cream. Does this take time and planning? You bet. Does it take money? Yes some upfront kitchen and pantry infrastructure cost but it will be waaaay cheaper in the long run as your grocery bill plummets. Is it joyful to make your own foods and feed them to your family knowing you’re not giving them poisons? You bet. Will you lose weight and reverse your metabolic disease? You bet. Can anyone do it? You bet. Is it easy? Not at first but once you adjust, there isn’t going back.
Good luck out there.