Ex-rivermen, Eli McBee and Seth Booker, set out to become fur trappers on the Red River. They encounter a couple of Jesuit priests who are trying to build a mission. All get caught in the middle of a tribal war between the Kiowas and Osages. Seth is mistaken for a god because of his dark skin and 6' height. He helps fight off a small pox epidemic. Eli falls in love with an Indian girl. They kill the Osage chief and stave off the war. Nothing special.