Perhaps I am biased, having a background in the arts, but this was one of the most fascinating science books I have ever read.
It is not a particularly controversial position to state that human beings do not see reality as it objectively exists; rather, we see an interpretation of reality based on the equipment we are working with (that is, human brains and bodies). As Thomas Nagel once pointed out, if you were a bat, your interpretation of reality would be completely different since you would be working with different sensory equipment that would provide you with different environmental feedback. (In fact, there is a short section near the beginning of the book detailing how a few different species perceive and navigate the world).
The thesis of this book is that human cognitive equipment comes with innate rules that shape our perceptions of reality. He elaborates on this with findings in neuroscience, experiments in cognitive psychology, and optical illusions that demonstrate how our perceptions work. Particularly interesting were the case studies where the equipment breaks down or is damaged. Probably the most well known of these is synesthesia (the cross wiring of two senses) but some of these conditions are truly bizarre: visual form agnosia (you can see colour, motion, and edges but you cannot bind them together as objects), paraprosopia (the different parts that make up an object - a human face, for instance - morph and change), hemiachromatopsia (seeing half of your visual field in colour and half in black and white), akinotopsia (you can see stationary objects but you cannot see them in motion), etc.
For the philosophically minded, a final chapter indulges in a wee spot of open ended ontological speculation.