The strength of the novel was its main characters, who were complex enough to shape how the plot unfolded around them. One man's delusions of unappreciated genius allowed other characters to outflank him, for example, or an overconfident drug lord crippled his own power when he failed to anticipate the foreseeable risks, shifting the novel's conclusion and changing which plotlines would be left unresolved. The result of so strongly interweaving the character of the characters into the story was a weak plot that couldn't stand on its own. While this wasn't a problem when sufficiently forceful personalities (and there are plenty!) were around, the plot faded into a bland static when it was left to the side characters. The novel realized this problem 70% of the way through and tried to fix it by discarding these nonentities, but by then fragile plot had been exposed, to the detriment of engagement and suspension of disbelief. Thankfully, the novel was smart enough to bulldoze past sections of weak, exposed plot and focus on its backbone: the characters.
Interestingly, the novel included a half dozen antagonists, each almost as fleshed-out as the protagonists. But instead of overwhelming the reader with tepid variations on an archetypal villain, each was given a unique motivation and mode of operation, ranging from lust for power by manipulating bureaucracies to fulfilling selfish ambitions with staunch self-reliance. They were often among the strongest characters in the book and were invariably interesting when they took center stage.
That said, the novel tended to get lost when its good characters were out of the picture. The overarching plot-an international arms race for a lethal nuclear weapon-boiled down to little more than physicists repeating that they'd almost got the nuclear reaction working and they needed two more weeks TOPS just give us a little more time...which got stale after about the third near-breakthrough that turned out to be nothing. Resultingly, the novel was at its best when it had left the lab and was reveling in underground firefights or caught up in the conflicting web of character action-interaction.
A final note on the writing quality: while clumsy in places (hardly unexpected in an author's first work of fiction) and easily baited into unnecessary subplots and character motivations, the majority of the book was easy to read and genuinely engaging. There was a tinge of overly-formal, almost academic, language in the narration, but it remained coherent even when starched.
Overall, a four star book with a strong base and lots of room to grow. When does the sequel come out?