Regenerative Properties of Central Monoamine Neurons: Studies in the Adult Rat Using Cerebral Iris Implants as Targets

by N.A. Svendgaard

Materials and Methods.- Animals 8, Operative techniques 8, Perfusion technique 11, Dissection procedures 12, Histochemistry 12, Microspetrofluorometry.- Vascularization and survival of irides transplanted to the caudal diencephalon and to the anterior chamber of the eye.- 1. Time-course of revascularization of the iris transplants.- 2. Semiquantitative evaluation of the revascularization and size of the transplants.- 3. Origins of the vascular supply.- 4. Discussion.- 5. Summary.- Reinnervation of irides transplanted to the caudal diencephalon.- 1. Sources of the reinnervating fibres.- 2. Time-course of reinnervation of the iris transplants by central NA fibres.- a) Sympathectomized animals.- b) Non-sympathectomized animals.- 3. Morphology and patterning of the regenerated central and peripheral NA fibres.- 4. Discussion.- 5. Summary.- Reinnervation of transplanted irides by central DA and IA fibres.- 1. Growth of central DA fibres into irides transplanted to the internal capsule.- a) Characteristics of the transplantation site.- b) Growth and patterning of the sprouting fibres.- 2. Growth of central DA fibres into irides transplanted to the caudal diencephalon, in the absence of regenerating NA fibres.- 3. Growth of central IA fibres into irides transplanted to the mesencephalic raphe.- a) Characteristics of the transplantation site.- b) Growth and patterning of the sprouting fibres.- 4. Discussion.- 5. Summary.- Growth of central NA fibres into chronically denervated irides.- 1. Growth and patterning of the regenerating fibres.- 2. Discussion.- 3. Summary.- General discussion.- General summary.- References.

82 pages, Paperback

First published January 1, 1975