After a high school education, Brush began her career as a columnist for the Boston Traveler. She published her first book, Glitter in 1926, but it was her short story Night Club which was published in Harper's Magazine in 1927 that brought her national recognition and an O. Henry Award. She became a well-known contributor to leading magazines of the 1920's and 1930's such as Cosmopolitan and Collier's Weekly. Her most successful work was Red-Headed Woman (1931), which was made into a film starring Jean Harlow in 1932.