This selection of international state-of-the-art research in applied regional science, places particular emphasis on illustrating the use of powerful model-based quantitative methodologies. A unifying theme of the collection is the integration of both econometric and input-output modelling, and their use at different spatial scales from local to multi-regional. The papers range from pure methodology to policy applications, and cover project evaluation, decision support systems and integrated urban system analysis. This book is intended for anyone conducting large scale social science research using quantitative data and a model-based approach.