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448 pages, Hardcover
First published January 1, 2009

Arsenic…was almost certainly the secret ingredient. Colorless, odorless, flavorless, arsenic could be added to any drink or dish. Mithradates knew that just sixty parts per million, or less than a tenth of an ounce, would be deadly in a goblet of rose-perfumed water or red wine…Mithradates, recalling the paradox of poisonous honey, savors the irony of creating a bittersweet treat. He stirs the arsenic powder into a pot of honey and drizzles it over the syrupy-sweet cakes…After dessert, the guests withdraw to admire the sunset. Within half an hour, the queen and her son sense a faint, metallic taste on their tongues. Beads of sweat glisten on their clammy brows as they become aware of impending nausea and stomach cramps. Saliva fills their mouths, but it is impossible to swallow. Their eyes take on an uncanny reddish sparkle. Suddenly the royal pair begin clawing at their throats, drooling and moaning. After an hour or so of vomiting and diarrhea, Mithradates’ mother and his only rival are writhing in convulsions…By midnight, both are dead.


"Beavers abound in Armenia's lakes and streams - perhaps their testicles contributed to Mithradates' celebrated vigor."
Mithradates VI Eupator
Illustration of Mithridates VI of Pontus learning Mithridatism practice of protecting oneself against a poison by gradually self-administering non-lethal amounts by Francesco Bertolini.
“Like mad King Attalus of Pergamon, Mithradates cultivated poison gardens of blue monkshood, polemonia (“plant of a thousand powers”), deadly nightshade, henbane, and the like, with his Greek “root-cutter” Krateuas, also of Pergamon. The first ethnobotanist and the father of botanical illustration, the Poison King’s fellow experimenter, Krateuas wrote two influential treatise that were among the king’s treasures brought to Rome after Mithradates’ death. The natural historian Pliny the Elder (AD 23-79) described these books, now lost. One was the first to include realistic coloured paintings of hundreds of medicinal plants; the other was a detailed pharmacology manual. Mithradates “was the first to discover several different antidotes to poisons,” noted Pliny, and “some of these plants even bear Mithradates’ name.” Krateuas named several plants after his patron—for example, pink Mithridatia (liliaceous Erythronium) and feathery-leaved Eupatorium.” ~Chapter 5: Return of the King, page 101.
“Another strong possibility is that the facial ulcerations—as well as the episode of acute paranoia—were the result of long-term ingestion of arsenic, part of Mithradates’ anti poisoning regimen. Prolonged exposure to arsenic can cause bouts of mental imbalance, hallucinations, and paranoia. Arsenic also causes keratoses, which progress after ten to twenty years to skin cancers. Notably, frostbite causes arsenic-related skin cancers to putrify. Frostbite, combined with a lifetime of tiny doses of arsenic and other photosensitising toxins such as rue and Saint-John’s-wort, appears to be the best explanation of Mithradates’ skin ailment.” ~Chapter 14: End Game, page 340.