The Physical Basis of Biochemistry: The Foundations of Molecular Biophysics

by Peter R. Bergethon

1 Introduction to the Principles and Practice of Biophysical Chemistry.- 2 Physical Thoughts, Biological The Application of Modeling Principles to Understanding Biological Systems.- 3 Probability and Statistics.- 4 Physical Energy-The Prime Observable.- 5 Physical Mechanics and Motion.- 6 Physical Waves.- 7 Physical Electrostatics.- 8 Physical Electromagnetics.- 9 Physical Quantum Mechanics.- 10 Chemical Principles.- 11 Measuring the Energy of a Energetics and the First Law of Thermodynamics.- 12 The Whole Is Greater than the Sum of Its Entropy and the Second Law.- 13 Which Way Is That System Going? The Gibbs Free Energy.- 14 Friends and Neighbors-Interactions in a Phase Equilibria.- 15 Analysis of Structure.- 16 Analysis of Microscopy.- 17 Scenic Overlook Backward and Forward.- 18 A Unique Structure, a Unique Solvent.- 19 Ion-Solvent Interactions.- 20 Ion-Ion Interactions.- 21 Lipids in Aqueous The Formation of the Cell Membrane.- 22 Constructing a Biological State Space.- 23 Macromolecules in Solution.- 24 Molecular Mapping Biochemical State Space.- 25 The Electrified Interface.- 26 Forces Across Membranes.- 27 A Nonequilibrium Process.- 28 Flow in a Chemical Potential Diffusion.- 29 Flow in an Electrical Conduction.- 30 Electrokinetic Phenomena.- 31 Chemical Kinetics.- 32 Enzymes and Electrons.- Epilogue.- Appendixes.- Appendix A Mathematical Methods.- A.1 Units and Measurement.- A.2 Trigonometric Functions.- A.3 Expansion Series.- A.4 Differential and Integral Calculus.- A.4.1 Partial Differentiation.- A.5 Vectors.- A.5.1 Addition and Subtraction.- A.5.2 Magnitude of a Vector.- A.5.3 Multiplication.- Appendix B Fictitious and The Centrifugal Force.- Appendix C The Determination of the Field from the Potential in Cartesian Coordinates.- Appendix D Hamilton's Principle of Least Action/Fermat's Principle of Least Time.- Appendix E Geometrical Optics.- E.1 Reflection and Refraction of Light.- E.2 Mirrors.- E.2.1 The Plane Mirror.- E.2.2 The Concave Mirror.- E.3 Image Formation by Refraction.- E.4 Prisms and Total Internal Reflection.- Appendix F Derivation of the Energy of Interaction Between Two Ions.- Appendix H Derivation of the Clausius-Clapeyron Equation.- Appendix I Derivation of the van't Hoff Equation for Osmotic Pressure.- Appendix J Derivation of the Work to Charge and Discharge a Rigid Sphere.- Appendix K Quantum Electrodynamics.- Appendix L Adiabatic and Nonadiabatic Transitions.- Appendix M Fermi's Golden Rule.- Physical Constants.- Answers to Selected Problems.

592 pages, Paperback

First published September 1, 2010