You will only have one hand free while reading Mastering Regular Expressions because Jeffrey Friedl will take you by your other hand and lead you through everything there is to know about regular expressions.
You will see your mistakes corrected as you make them, you will ask questions and find their answers at the end of the page, and when Jeffrey explains concepts in Ruby, right before you open your mouth to tell him that you only code in Java, he will point to the next page where you will find the same code written in it.
The first couple of chapters are an introduction to the subject, with a few examples that increase in complexity as you go on. By the end of the third chapter (only a third of the book), you would already know every possible RegEx mechanic.
However, throughout all that, you will come across notes on many examples, explaining that they will be revisited in later chapters to correct a few mistakes or be made more efficient, with page numbers referencing where to ease the book's navigation.
But before beginning with the advanced techniques, Jeffrey takes a break from the subject of usage to explain the inner workings of RegEx engines. Without showing any code, you are shown how engines go about parsing expressions and exactly why some patterns perform worse than others in certain situations.
By the time you begin with the advanced techniques, you will find yourself equipped enough to understand the reason behind each of them. And I would like to believe that at that point, like myself, you will bow to the brilliance of Jeffrey E.F. Friedl and the way he explains concepts.
The last few chapters each discuss regular expressions for certain languages. Like most readers, I skipped the ones that didn't concern me (Ruby and .NET). I must say that even there, I was still surprised to find extremely specific tips, signifying the time spent using and researching these libraries for the sole purpose of writing these sections.
Mastering Regular Expressions is a book made with great brilliance and dedication, it provides a fantastic reading experience with its examples and references, and I doubt you would find any better book on the subject.