Emilie (born Smith) grew up in the archipelago of Bohuslän. Her father, Rutger Smith, was a retired sea captain who had settled down as a small merchant, and she often accompanied him on the voyages he made along the coast. She thus came in frequent contact with the seafaring folk, fishermen, and smugglers who were to populate her later stories. At the age of twenty, she married a local physician, Axel Flygare, and went with him to live in the province of Småland. She was widowed in 1833, returned to her old home, and decided to devote herself to literature.
She moved to Stockholm some years later, and in 1841 she married a lawyer, publicist and poet of that city, Johan Gabriel Carlén (1814–1875). Her house became a meeting place for Stockholm men of letters, and for the next twelve years she produced one or two novels annually. The premature death of her son Edvard Flygare (1829–1853), who had already published three books, showing great promise, was followed by six years of silence, after which she resumed her writing until 1884.
She founded charitable endowments in aid of students and of teachers, and of fishermen and their widows. She is best known by the hyphenated name Flygare-Carlén. Her daughter, Rosa Carlén (1836–1883), was also a popular novelist.
1001 böcker Sid 42, mening 1: ”Den adertonåriga Emilia, med sina feberaktiga känslor, sin lättretliga stolthet och sin barnsliga, besvärande fruktan att icke rätt kunna ställa sig i sina nya förhållanden, utgjorde den skarpaste motsats till den tjugotvååriga tvärsäkra Majken, som rökte sin cigarr ikapp med kapellpredikanten, under det de vexelvis berättade sina historier, som obesväradt drack hvar främmande kapten till vid fadrens bord och som, utan att darra på handen, styrde sin båt i både dödsjö och storm, då hon var ute på jagt efter sjöfågel.”