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The Hybrid Cure

Runner-up for YA science fiction in the 2025 Incipere Awards.

A devastating plague. Kids treated like lab rats. Can a teenager develop her powers in time to rescue the ones she loves?

London, 2042. Ofelia Stykes can’t forgive herself. Having lost her older sibling to the snatchers, the nearly sixteen-year-old scavenger vows to protect what’s left of her family from the lethal pandemic that toppled society. But when her little sister is captured as they dig through trash for treasure, the brave teen surrenders herself in exchange for the child’s freedom.

Locked in a research facility and subjected to tests, the desperate young woman shrewdly searches for an opportunity to escape with the rumored cure. But with the morally bankrupt chief virologist believing Ofelia’s DNA could save all of humanity, the extraordinary teen fears time is running out before she’s the next to die in a horrific experiment.

Can she uncover the truth and prevent an earthshaking disaster?

The Hybrid Cure is the rollicking first book in The Kaseath Chronicles, a YA dystopian science fiction series. If you like heroines to root for, action-packed suspense, and exploring the slippery slope between good and evil, then you’ll enjoy Jackie McCarthy’s coming-of-age adventure.

366 pages, Kindle Edition

First published January 3, 2023

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About the author

Jackie McCarthy

3 books10 followers
Strong female characters and quirky, inspiring tales.

Jackie writes Young Adult (YA) and New Adult (NA) science fiction and fantasy. She is partial to dystopian and futuristic stories with a magical twist.

She has worked in publishing and the media for over 20 years, in both London and Sydney. Her debut novel, The Ghost Mothers, is very loosely inspired by her time working in the magazine industry, many moons ago.

Jackie's new release, Rebel Conspiracy, is the rollicking second book in The Kaseath Chronicles, a YA Dystopian science fiction series. If you like heroines to root for, action-packed suspense, and exploring the slippery slope between good and evil, then you’ll enjoy Jackie’s coming-of-age adventure.

If you would like to be notified of new books as they are released, you can sign up for the Reader's Group here:
www.jackiemccarthy.com/sign-up/

She thanks you for stopping by, and for your reviews!

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Displaying 1 - 18 of 18 reviews
2 reviews
January 9, 2023

At 366 pages, this self-identified ‘YA Sci-Fi Post-Apocalyptic Adventure’ is indeed that! The characters certainly face plenty of challenges in their dystopian world.

The novel’s protagonist Ofelia at 15 years is coming of age, making decisions and taking responsibility for those decisions. She is different, having scales on parts of her body and has grown used to being targeted because of her difference.

Speaking in the first person, Ofelia details her daily routine of scavenging on Trash Mountain with other Northies, returning to a shack she shares with her mother, stepfather and younger sister, Imogen who suffers symptoms of plague. Ofelia makes every effort to keep Imogen safe as they avoid capture by the ‘Snatchers’ who kidnap children. She feels guilt for not having protected her step sister Demi, who met that fate.

Ofelia is determined to access a cure for the plague that she believes is available and also to locate Demi and bring her home. During this quest she herself is captured and by accident finds she possesses special powers to freeze time. This proves very useful as she becomes part of experimentation by Drs Figg and Wood in their lab during her captivity.

While in captivity Ofelia hears a voice in her head. This is revealed as communication from Trix, a strange looking alien, also a prisoner who has similar, stronger powers. Ofelia and Trix have much more in common than one might think. This is where the story picks up momentum. Trix is a star: truthful, loyal, on a peace mission to stop humans leaving earth so they don’t damage other parts of the universe. What’s not to love!

Ofelia and Trix team up to pursue their goals to locate the cure and to bring Demi home, while outwitting the evil and corrupt. The resolution shows Ofelia has grown in maturity and leaves the way ready for the next chronicle.

I like that there’s a strong and feisty female protagonist. I also like that from referring to her step-father, Roland, as ‘useless’ in chapter 2, Ofelia comes to respect him as a decent man who does his best to care for the family – a sure sign that she’s growing up. An aspect of a diverse society that is demonstrated is inclusion of Aze – a person of colour, as well as Maya and her family from Goa – quite subtly achieved. McCarthy’s decision to keep the chapters short is a plus, helping the reader navigate the length of the novel.

The novel is ambitious and shows opportunities for further development of the main characters. While I confess I am not part of the YA target audience, readers interested in this genre will eagerly await the next instalment
Profile Image for Katie Steuerwald.
90 reviews2 followers
January 4, 2023
I really enjoyed reading this book. Ofelia's life in the future is hard. Trying to survive and protect her family.
I liked learning more about her life and what the world is like in the future.
When she is taken by the snatchers the adventure really begins.
I am looking forward to reading the rest of the books in the series to find out what happens next.


I received an ARC from the author and am voluntarily leaving an honest review.
Profile Image for Jasmine.
151 reviews
January 23, 2023
Non stop action from start to finish! Looking forward to the next installment to find out more about how this future world works and what’s in store for Ofelia and her friends.
Author 3 books1 follower
October 3, 2026
The Hybrid Cure is an engaging YA dystopian adventure that wastes very little time getting its central mystery moving. Ofelia is a memorable protagonist: a nearly sixteen-year-old girl living in a brutally impoverished community, trying to protect her chronically ill younger sister while hiding the strange scales that mark her as different. Between scavenging Trash Mountain, dodging the people who control her neighborhood, and desperately searching for a cure for Imogen's plague, she has plenty of problems before the aliens even enter the picture.

The worldbuilding is one of the book's biggest strengths. The Northies community feels genuinely bleak without becoming completely hopeless, and the details of everyday survival such as rationing food, scavenging garbage, black-market currency, government-controlled television, and children growing up without normal schooling give the dystopia a tangible quality. Trash Mountain in particular is a great setting, and the contrast between the impoverished Northies and the mysterious world beyond it creates an effective sense of curiosity.

The relationship between Ofelia and Imogen is the emotional core of the story, and it works well. Ofelia's determination to protect her sister drives virtually everything she does, including many of the increasingly dangerous decisions that propel the plot forward. Her guilt over what happened to Demi adds another layer to that relationship and gives her determination a personal history rather than making her simply a generic teenage hero.

The story also does a good job gradually expanding its scope. What initially appears to be a straightforward search for a plague cure becomes something much stranger involving Doctor Figg, the government, the alien Trix, genetic experimentation, time-related abilities, and the possibility that humanity's understanding of the plague and the aliens is fundamentally wrong. I particularly enjoyed the way the mystery surrounding Ofelia's unusual appearance eventually connects to the larger alien storyline.

Doctor Figg is probably the most interesting character outside the main group. She isn't written as a simple villain, and her justification for conducting horrific experiments creates some genuinely uncomfortable moral questions. Her belief that sacrificing a relatively small number of people might ultimately save humanity gives the story something more substantial to chew on than a straightforward good-versus-evil conflict.

The book does occasionally become a little exposition-heavy, particularly once the larger mythology and Ofelia's abilities start being explained. There are also several major revelations packed into the latter portion of the story, and some of them might have benefited from being given a little more room to breathe. Still, the constant revelations and escalating stakes make the book very easy to keep reading.

I also appreciated that the story ultimately keeps its focus on Ofelia's family rather than allowing the alien conspiracy and superhero-like abilities to completely overwhelm the original premise. Beneath all the science fiction, dystopian politics, and extraterrestrial mysteries, this is fundamentally a story about a teenager who desperately wants to keep her family together.

Overall, The Hybrid Cure is a fast-moving and imaginative start to The Kaseath Chronicles. It combines dystopian survival, alien science fiction, mystery, and coming-of-age themes while leaving plenty of unanswered questions for the next book. Ofelia's story feels like it is only getting started, which makes this a promising opening installment to the series.
Profile Image for Brian Townsend.
Author 2 books20 followers
August 19, 2026
A Strong Dystopian Tale with Imaginative Worldbuilding
The Hybrid Cure is a vivid and energetic young adult dystopian novel that succeeds through strong worldbuilding and a clear emotional core. Jackie McCarthy creates a post apocalyptic London that feels lived in, broken, and strangely beautiful. The divide between the Northies and the suburbs is sharply drawn, and the details of scavenging culture, black market cures, and authoritarian control give the setting a sense of weight and history.
The story follows Ofelia, a young girl marked by mysterious scales and unusual abilities. Her journey is driven by her desire to save her sister Imogen, and that motivation keeps the narrative grounded even when the plot expands into alien contact, government conspiracies, and scientific experimentation. Ofelia is a sympathetic protagonist, and her mixture of fear, determination, and confusion feels authentic for a character her age.
The supporting cast adds texture to the world. Maya, Mousie, Aze, and Trix each bring something distinct to the story, and their interactions with Ofelia help shape her growth. Trix, in particular, is an interesting presence. The mental bond between Ofelia and the alien adds a layer of mystery and emotional complexity that elevates the book beyond a standard dystopian adventure.
McCarthy’s strongest skill is atmosphere. The facility scenes are tense and unsettling. The Northies are harsh and believable. The suburbs are polished but hollow. The contrast between these environments highlights the social divide and reinforces the stakes of Ofelia’s mission. The book moves quickly, and the pacing keeps the reader engaged without feeling rushed.
Readers who enjoy young adult dystopian fiction will find familiar elements here, but the hybrid concept and the alien connection give the story its own identity. The book balances action with character moments, and it ends with a sense of hope that feels earned rather than forced.
The Hybrid Cure is a well crafted young adult novel with strong worldbuilding, memorable characters, and a clear emotional throughline. It is an enjoyable read that blends dystopian grit with science fiction wonder.
Profile Image for Fiction and Tea :D.
119 reviews12 followers
June 9, 2025
A bold new voice in YA dystopian.

The hybrid cure is an immersive debut that pulses with heart grit and unrelenting tension. Set on a plagued post apocalyptic earth, the novel is written from the perspective of a 15 year-old girl with lizard like scales on her skin. From the start she is not your typical heroine. Branded as lizard freak by others, she is scavenger who spends her day looking for food in the trash mountains

The novel ships into a high gear when she decides to find a cure for her little 🧑 and is captured by merciless scientist Figg and Wood. It is in captivity that she discovers something about her that changes her life for ever and she meets a telepathic piece seeking alien. Soon she discovers that she and the alien have similar capabilities and managed to escape from prison. However, she discovers that if she wants to survive in this world there might be no escape.

The Author keeps the chapter short and sharp which makes this interesting and fast read. The pacing is tight and action is relentless with touch of humour which made me laugh from time to time. I definitely like the main character but I also like the way the other characters like Maya and Aze introduced subtly and I like the fact that the Author made them quite real by doing research on cultural backgrounds.

The Author succeed in building a diverse and inclusive world without drawing and your attention to it. That definite echoes of the hunger games but this book has its own path. Ultimately this book is more than a survival story. It’s about identity sacrifice and the strength it takes to face a broken world and how hard it is to heal it.

Looking forward to read the next book.
Profile Image for Huey Carroll.
Author 13 books13 followers
August 8, 2026
Hope Has Teeth in a Broken World

The Hybrid Cure by Jackie McCarthy carries an emotional weight that lingers beyond its final pages. Beneath the dystopian adventure is a story about loyalty, guilt, and the desperate need to protect the people who matter most, giving the novel more heart than its premise initially suggests.

What stayed with me most was Ofelia. She isn't fearless; she's stubborn, fiercely protective, and burdened by the belief that every failure to save someone is hers to carry. That mixture of determination and self-doubt drives nearly every major decision, making her victories feel earned rather than convenient. Her relationship with her plague-stricken sister provides the emotional center that keeps the larger science-fiction mysteries grounded.

McCarthy's prose is precise and atmospheric, painting a convincing world of scavenged survival without drowning the reader in exposition. The pacing is largely a slow burn early on, allowing the setting and characters to breathe before accelerating into a far more relentless second half. A few plot revelations arrive conveniently, but they rarely undermine the story's emotional momentum.

I would recommend this book if you prefer character-driven dystopian fiction over nonstop action, and emotional stakes over spectacle.
Profile Image for Marcia.
104 reviews1 follower
January 17, 2023
Really enjoyed MCarthy's new book The Hybrid Cure.

Set in a post apocalyptic world, Ofelia (aka Lizard Freak) and her little sister Imogen (AKA plague girl) are Northies Rats trying to survive in a dog eat dog world where Shifty Pocks (the Northies king pin) rules the roost and decides who gets a place to live, and rations. The girls live with their mum, and their 'useless' step dad Roland. They had a step-sister once, Demi, but she was taken by the men in black and the woman in the baseball cap. Ofelia still feels guilty that she didn't try to save Demi, and she'll do just about anything to protect Imogen and try to find a cure for the plague her little sister suffers from, even if that means breaking into the secure facility where Dr Figg is working on a cure.

Captured by the men in black, taken to be a lab rat in that same secure facility, Ofelia begins to discover who she is, why Dr Figg thinks she's special and wants her DNA, and the benefits to having those orange lizard scales as she makes contact with the Kaseath.

McCarthy has written a book with believable characters, plenty of action and suspense that leaves you wanting more. Can't wait for book 2 in the series.

Highly recommended for YA readers.
60 reviews1 follower
September 28, 2026
The Hybrid Cure is a gripping blend of dystopian tension and emotional depth, pulling you straight into a world where survival depends on choices no one should ever have to make. The story’s central premise is a deadly virus and the desperate search for a cure which feels both urgent and unsettling, and the author uses that pressure to explore how far people will go to protect the ones they love.

What stands out most is the character work. McCarthy gives her protagonists real weight that encompasses fear, hope, guilt, and determination which all collide in ways that feel painfully real. The relationships, especially those strained by secrets and sacrifice, add emotional richness.

If there’s a drawback, it’s that some moments move so quickly you may wish for a little more breathing room, especially when the worldbuilding introduces new scientific or political elements. But even with that, book remains a compelling, thought‑provoking read that blends action, emotion, and moral conflict into a story stays with you. It’s a strong choice for readers who enjoy dystopian fiction with heart and high stakes.
Profile Image for H.G. Ahedi.
Author 24 books55 followers
June 9, 2025
In The Hybrid Cure, Jackie McCarthy delivers a gritty, fast-paced dystopian adventure with real emotional weight. Ofelia, a teen outcast with mysterious scales and a fierce love for her plague-stricken sister, survives by scavenging in a broken world. When she's captured by sinister scientists, she discovers strange powers—and meets Trix, a telepathic alien with a mission of peace.

What starts as a fight for survival turns into something much bigger: a quest for truth, justice, and a cure. With rich world-building, a diverse cast, and a heroine you can't help but root for, The Hybrid Cure is a strong, smart YA debut. Think The Hunger Games meets The Fifth Wave, but with a sci-fi twist all its own.

Short chapters, non-stop action, and big emotional stakes—this is one you’ll finish fast and immediately want more.

Perfect for readers 13+ who love dystopia, sister bonds, and bold, flawed heroes.
Profile Image for Carmela Dimattia.
2,145 reviews22 followers
January 2, 2023
This was a very interesting read by Jackie McCarthy. It is set in the future after an apocalyptic event. Ofelia has lost it all and she is our heroine in this book. She will do whatever she can to protect her remaining family including exchanging her life for her younger sister. Can Ofelia help mankind or is mankind doomed? I enjoyed this book even though this is not my usual genre but as a massive fan of The Walking Dead I knew I had to give this book a chance and I was not disappointed. This is the first book in this series and I am very keen to get my hands on the next book to see what the author has in store for Ofelia, and us readers.

I received an arc copy from the author and am voluntarily leaving an honest review.
Profile Image for Jessica.
250 reviews13 followers
August 29, 2026
Exciting YA science fiction

The Hybrid Cure follows Ofelia, a sixteen year old living in a metal shack with her family, in Northies, where kids spend their days scavenging for anything useful they can find in the mountains of trash where they live. The action really gets going when Ofelia decides that she's going to take matters into her own hands and find out why Northies kids, like her sister, are being taken. She discovers that she is more important to the powers that be than she thought possible. The action is nonstop, as Ophelia makes her choices to save the people she loves using powers she is discovering as she goes.
Profile Image for Gabriel Pollard.
5 reviews
August 20, 2026
This book The Hybrid Cure caught me by surprise. My first thought was that it was a follow up to Brid. I was wrong. That said, it is a good read for anyone seeking a book centering around teenagers who live in a dystopian time period in search of a cure to a virus that has turned everyone into hybrids with unique abilities. The book is ultimately a good read that will leave it's readers wanting more page after page. It delivers adventure and intrigue from start to finish. I recommend this book to everyone in search of a good read!
Profile Image for C.I. DeMann.
Author 3 books19 followers
September 24, 2026
This is a very solid and enjoyable post apocalyptic YA novel. I think the world-building was good, the characters were solid (especially Ofelia, the main character), and the exciting and suspenseful pace was well done. I thought the details of the plague were well thought out and there were some good twists involving Ofelia's DNA. Quality adventure tale that I'd recommend to anyone who likes post apocalyptic or YA or post apocalyptic YA.
3 reviews
January 8, 2023
What a romp of a good story! The author paints such a colourful canvas with her words and I was drawn into the adventure right to the very last page. With a cast of interesting characters and a complex and well written story, now I have to be patient and wait for the next book to find out what happens! Ofelia is a heroine we can all get behind.
Profile Image for Kat M.
5,428 reviews18 followers
January 28, 2023
this was a great start to the Kaseath Chronicles series, it was what I was hoping for in a sci-fi novel. I loved the post-apocalyptic feel to it and thought it worked well together. The characters were wonderfully written and I'm glad I got to read this.

I received a free copy of this book via Booksprout and am voluntarily leaving a review.
Author 1 book2 followers
August 11, 2026
I usually love dystopian books, so it was no surprise that The Hybrid Cure had me hooked straight away, and I struggled to put it down. The emotions in this book are incredibly written; the twists and turns keep you hooked, and the constant danger keeps the tension super high. Looking forward to reading the next book.
59 reviews
January 18, 2023
Great story! Sci-fi is not not usually my first choice but I really enjoyed this book.
Displaying 1 - 18 of 18 reviews