Conceived from the love between the most powerful werewolf on the North American continent and the wife of a gambling, abusive drunkard, Julian Kingsman rises to become one of the most powerful lycanthropes on the planet. He falls in love with a woman named Mary and she carries his child. They are pursued by an organization whose sole purpose is the eradication of supernatural creatures such as werewolves and vampires. How they survive while on the run, deal with the curse of their cyclical insanity and eventually face those who hunt them is a story of terror, horrific carnage, courage and the unbridled satisfaction of base carnal instincts sharply contrasted against one human's love for another.