Eyeshield 21: Is There a Loser in the House? continues where the previous tankōbon left off and contains the next nine chapters (80–88) of the on-going manga series.
As the Deimon Devil Bats train in the United States, Shin is doing a special training in the thin air of Mount Fuji to improve his cardiopulmonary functions. Patrick "Panther" Spencer appears and challenges him. When he tries to pass through Shin, he is stopped with just one arm.
Meanwhile in the United States, Sena Kobayakawa kicks the rock out of the road and he is separated from the rest. He ends up in the San Antonio Armadillos Stadium, where he meets Suzuna Taki and Natsuhiko Taki. The girl is following his brother who wants to be a professional football player.
Natsuhiko Taki and Sena Kobayakawa then participate in an enrollment match to join the Armadillos, during which Sena Kobayakawa performs the running technique to cut the opponent without losing speed. Although Natsuhiko Taki is not approved, he and Suzuna Taki join the Deimon Devil Bats in the Death March.
When they arrive in Las Vegas, the Deimon Devil Bats win 20 million yen in a casino. They then can pay for Doburoku Sakaki's debts that were keeping him in the United States and he can join them as their manager in their return to Japan.
This tankōbon is written by Riichiro Inagaki and illustrated by Yusuke Murata. For the most part, I really liked the story and the progression. I am rather glad that the Deimon Devil Bats excursion to in the United States of America is done and that they would be returning to Japan. While their time in America was rather interesting – I am glad that they are returning home.
All in all, Eyeshield 21: Is There a Loser in the House? is a wonderful continuation to a new series that seems intriguing and I cannot wait to read more.