This is a beautiful and accessible-yet-thorough introduction to proteomics. It provides a survey of the field, from thermodynamics to prion disease to biochemistry. Desktop publishers made mindful design/layout decisions; this text is easy to read. The book features a plethora of 3D-modelled protein structures. It even includes practice problems to test one's comprehension of the material. This is a to-be classic in elementary proteomics. I know that I'll be revisiting Lesk's book time and again.