Systems Biology: Properties of Reconstructed Networks

by Bernhard O. Palsson

Genome sequences are now available that enable us to determine the biological components that make up a cell or an organism. The new discipline of systems biology examines how these components interact and form networks, and how the networks generate whole cell functions corresponding to observable phenotypes. This textbook describes how to model networks, determine their properties, and relate these to phenotypic functions. Some knowledge of linear algebra and biochemistry is required, since the book reflects the irreversible trend of increasing mathematical content in biology education.

Genres: Biology, Science

336 pages, Hardcover

First published January 1, 2006

Reviews

[Jason Yang · Rating 5 out of 5]

Bernhard Palsson's 'canon' on systems biology. I thought this was a well written textbook. The problem is well-motivated and the constraint-based approach presented here make intuitive sense.

I particularly appreciate the descriptions of transformations between reactions and reactants, pathways and pools. The math was reasonably limited and easy to follow. I was reading this book mainly to teach myself about metabolic modeling and felt that my lack of prior expertise was not a significant barrier. Definitely a textbook I would recommend for self-study.

[Ryan · Rating 5 out of 5]

No better book at gathering an understanding of systems biology.

[Daniela]

Have to read it for the class I'm helping with. Good introductory book.