My notes while reading the book:
The book doesn't give you ready theories, but takes you through the process of discovery.
Raises many questions on how the brain works. Very interesting topics.
He uses many experiments to probe and investigate. He's influenced by Thomas Kuhn and uses his terminology very often.
Preface by Oliver Sacks
V. S. Ramachandran. Phantom limb. Other topics too that show how our brain works in what Rama calls "experimental epistemology".
The books he liked when he was young. Praises the book.
Preface by Rama
Galileo, Darwin, Huxley, Faraday, Humphrey Davey and others all wrote popular science books.
Francis Crick influenced by Shrodinger's book What is life.
Paul Dicrove (or Decroff), The Microbe Hunters was an influential popular science book as well.
Author influenced by books of George Gammo, Luis Thomas and Peter Medower.
Also Oliver Sacks, Steven J. Gould, Carl Sagan, Dan Dannet, Richard Gregory, Richard Dawkins, Paul Davies, Steven Pinker and Colin Blakemore.
Story of Galileo. Discovery of H. pylori (by Marshall). He was just a medical resident and didn't need any sophisticated equipments. Discoveries are just under our noses waiting for us to discover them.
Speculation and imagination is a very important process as a starting point for discoveries in science. This productive even when the speculations are wrong.
Many open questions in neurology
Chapter 1: The Phantom within
Many inspirational quotes.
Religious experiences and temportal lobe epilepsy. Phantom limbs. Large blind spot in vision, with cartoons appearing. Anasgnosia patient who doesn't identify her paralyzed arm as her. Patient who kept laughing all day until he died. Patient after an accident who though his parents were duplicate imposters.
All these are due damage in a certain part of brain.
Neuroscience is in the stage of Faraday and didn't develop yet to the stage of Maxwell.
Describes parts of the brain.
2 models for how brain works: modularity vs wholism.
Case. Patient who is fighting with her left hand which she can't control. This started after a stroke. Did the stroke damage the corpus colosum and therefore the left hemisphere inhibitory messages were interrupted.
Smiles when natural are produced by a different process (basal ganglia) than when told to smile or when looking at mirror (motor cortex). This is clearly seen in patients with stroke in motor cortex who perform full natural smile, but their forced smile was only half (vice versa for patients with basal ganglia stroke).
Hippocampus responsible for forming new memories. When removed their new memories are shortly lived only.
The region of brain responsible for calculation. A patient who can't calculate. He understands what numbers are and what is an infinity. Laughed aylt a joke involving numbers. Stroke in Angular Gyrus. Has Discalculia and finger agnosia.
These examples are pro-modularity.
Chapter 2: Knowing when to scratch
Tom. Phantom limb after an RTA. Wants to link this to nature vs nurture debate - are body maps in brain fixed by gene or do they change with experience [says the debate is still open. It isn't, both play part in us and cannot be separated.].
Phantom breast and phantom appendix. Other examples with penis, uterus, face..
No sufficient medical explaination. Only observations recorded and no experiments done.
Human huminculus map. Proportions of each organ.
Touching Tom's face and upper shoulder gave him perceptions in his phantom limb. The face and shoulder area in brain are next to hand.
MEG to map brain (very similar to human huminculus results, but this one non-invasive). Their map is changed from the normal. What is the significance of this?
Phantom legs felt when genitals were stimulated or at orgasm (again due to their near location on brain sensory cortex).
A dude with ambutated leg felt orgasm not in his oenis but in his leg which made it feel much better. The man who mistook his foot for a penis.
Could this explain the reason behind foot fetishes? Lol.
Ear lobes stimulate phantom breasts.
Chapter 3: Chasing the phantom
J. B. S. Haldane God must love beetles. Rama God must be a map maker (so many maps in brain - 30 for vision alone).
Lady born with no hands, but feel phantom limbs. But the phantom limbs are shorter than the prosthesis arm.
A telescoped phantom limb. The guy felt pain when the dr pulled the cup while the phantom fingers were around it. This rasies questions about the role of vision in this sensation.
1/3 of phantom limbs are frozen/immovable.
Motor cortex and supplementary motor area (for more complex movements such as doing good bye sign). Cerebellum and parietal lobe (for feedback? body image?)
Phantom limb depends on two processes:
1. Remapping of brain areas.
2. ?
Here he got the idea of creating the illusion that the arm was intact. Virtual reality was very expensive so he had to think about another method. Mirrors and boxes.
First done on Philip Martenes in 1984. It worked from the first attempt, immediately, but his eyes had to remain open!
This supported his theory of "learned paralysis".
After a while the phantom arm was gone for gone. The shoulder was gone, but fingers were still there. This was a first in medical history. Speculates on why this has happened.
The process of remapping after limb loss is a pthological one, and errors in this could give rise to the pain people with phantom limb pain have. Also pain memory from the lost limb.
The mirror box works 50% of the time. Is the box a cure or merely a placebo? This possibility was eliminated.
Is the pain due to brain giving orders to clinch more and more as there is no negative feedback from properioception or skin surface since the limb is amputated? The mirror might then provide the feedback needed for the brain to stop giving these orders which seem to be the source of pain?
You the normal person can imagine the pain without feeling it, because we have skin in our limbs which gives signals to our brain telling it what is reality and what is imagination.
Experiment on a patient. Made her think it was her hand movong when it was another hand. She still felt it was the phantom hand moving. This shows the role of vision in giving this illusory feeling.
Anatomically impossible positions work too. They can hurt.
Says his findings show that modularity of brain is wrong.
Phantom limb arises from a complex interaction between nature and nurture.
Leprosy patients don't experience phantom limbs when losing their limbs slowly via disease. But when amputations are made they get phantom limbs.
Two body images in brain, one genetic unchanging and one up to date. They compete when limb amputation happens (it disturbs the equilibrium in favor of the genetic body image).
Pain like all other sensory perceptions is an illusion created in the brain. Using one illusion to destroy another is no surprise afterall.
Nise tapping experiment to show how our body image can change within seconds. Dummy hand/table experiment too. [Isn't this the same when he extend our sensation to car? He addressed this point and extends it to other people].
GSR device (to measure skin changes for fear). Works with the table experiment.
Body image is a transient internal construct. A mere shell that you have temporarily created to pass off your genes to your offspring.
Chapter 4: The zombie in the brain
Dyan, a patient with a special case. CO poisoning. Coma and had brain damage associated with vision. She was practically blind, but had unconscious vision. Blind vision.
The puzzle of the symbolic language used by brain for vision perception. Vision is a subtle (unconscious) form of inference [all observation is theory-laden].
30 areas for vision: motion (a case of a patient without it), color area (damage to this area is different from the hereditary color vision -which is about photo receptors in the eye-, in this one -located in visial cortex- you see everything black and white),
2 paths for vision: Superior Coliculate (old pathway) and Lateral Gyniculate Nucleus (new pathway). The old pathway is blind sight (vision for action pathway or the how pathway). Why does the new pathway (the what pathway) have a privileged space in mind?
What would happen if the how pathway is removed? Ballet's syndrome (damage of paratiel lobes). Reaching to things becomes harder and a tunnel like vision dominates.
Binding problem.
The problem of vision is soluble, discovering the pathways and visial regions is a big step forward.
The many "zombies" (i.e. unconscious controls) within you
The self "I' as an illusion.
Chapter 5: The secret life of James Therber
Blindness caused him visual hallucinations. Were so wonderful and facinating. Charles Banney syndrome. This affects millions of people worldwide.
These involve logically impossible things.
Difference betweeb seeing and imagining. Vision is an active constructe process. "Filling in" or perceptual completion. Vision is an educated guesswork, and so is science.
Blind spot, decapitating people with it (lol) and its creative use.
The filling by the brain can compensate even big loses in vision (schatoma), and it does it very well that it takes effort to notice it (e.g. not seeing the "wo" in women and thinking it's the men bathroom).
An experience which shows process of filling in happening live (the two lines were gradually completed by his brain until they were linked).
Confabilation ruled out by using big X's and small x's. He said only the small ones were completed. Number completion doesn't work, they look like heroglephics.
Author concludes this shows that perception is not a single process, but several.
Perceptual and conceptual filling in (the first happens by itself and you don't have a choice about it - it's simple and not guesswork or deduction like the latter).
Guesswork is economic and saves energy as it doesn't need to scrutinize all the surface.
Charles Bonne (discoverer of Parthinogenesis). The guy who discovered the visual hallucinations of blind or visually impaired people.
Mentiones several cases of this syndrome. The hallucinations are up down (from memory) rather than bottom top (from perception).
In normal people the normal sensation from the organs limits the hallucinations, whereas for impaired people no such inhibitory feedback is present
Chapter 6: through the looking glass
Hemineglect following a stroke (completely ignoring one side of your visual field). This is neglect and not blindness [lazy eyes]. This happens only with right paraietal damange (and not left).
The reason behind this asymmetry is not well understood, but here's a speculation. Right hemisphere has a large global search light, while the left has a small searh light because it's so busy with other things.
Cases of neglect patients and how they are managed. Mirror experiment; very strange result, she tried to grap the object from behind the mirror. Named it "Mirror agnosia" or "Looking glass syndrome".
Only a minority of neglect patients responded positively and correctly reached to the left neglected side.
Mirror agnosia as a cheap test for right paraitel lesions
This makes us reflect in the reality of what we normal people see and how our sensations can distort the rules of nature (such as that of optics for mirror agnosia patients)
Chapter 7: The sound of one hand clapping
Anosagnosia (unaware of illness). Paralyzed in half of their body due to a stoke, yet she vigorously denies it. She is otherwise very smart, sane and knows what happened to her.
Claims to be moving her paralyzed hand despite all the contrary evidence to the opposite! Claims to be seeing it move. Claims to be clapping. Astonishing confabilation.
Other similar patients bring up excuses ans rationalizations as to why their paralyzed parts won't move (e.g. I'm just tired of people examining me and don't want to move my arm, or claim to have painful arthritis or to be bad at aiming).
All of these are methods of self-deception. Freud wrote about how we deceive our selves when faced with unpleasant facts about ourselves.
Others claimed the paralyzed hand wasn't theirs (their brother hand). This is known as Somatoparaphrenia.
Two ways to explain this: Freudian and neglect syndrome. Problems with both explainations. He looks at differences between the hemispheres. His explaination is a combination of the two.
Left hemisphere is like a conservative dude who would believe in all sorts of delusions and not change his model. He represses and denies info that doesn't fit. Right hemisphere as a revolutionary who wants to change the model and detects discrepancies. When the right is damaged, the left wins by default.
Denial is part of human nature, wether about addiction, debts or the finality of death.
Rwo tests to make sure of the denial of anasgnosia patients.
Strange comments by these patients about doing activities with both hands as if somewhere in their brain they knew about their paralysis and were resisting it.
Experiment to show that the denial is present even with other body parts such as the other functioning hand (right hand). There are degrees of denial between patients, some global and some more limited.
The right hemisphere discrepancy detection confirmed by PET scan.
Experiment for reverse denial? Cold water in ear worked as a truth serum and made the patient recognize her paralysis. Her denial personality returned few hours later and she denied confessing to being paralyzed. It is as there are 2 different consciousnesses, one truthful and one in denial.
Normal people too have more than a personality; example from dreams where you tell yourself things you don't know or laught wholeheartedly at jokes.
REM sleep to have a semilar effect to cold water in ear in removing denials. Freud!
Memory, the holy grail of neuroscience. Repression and selective amnesia.
After getting out of denial, patients become amnesiac about their denial and claim they had always told the truth.
What about when we make it acceptable for the belief system of patients to admit their paralysis such as injecting them with just water and telling them this would cause their (paralyzed) hand to be paralyzed. He calls this "experimental epistemology". The patient said her arm was paralyzed!
When the same thing was done to the functioning arm, it was not paralyzed even though both were given the same injection. The patient rationalized this by saying it was mind over matter.
"What we call rational grounds for our beliefs are often extremely irrational attempts to justify our instincts." - Thomas Huxley.
Freud wrote a whole deal of nonsense. His discovery of the unconscious mind and Defence Mechanisms however were amazing. He didn't do experiments to confirm his ideas, but Rama patients displayed the whole list of these mechanisms right before him.
Denial. Repression. Reaction formation. Rationalization. Humor. Projection.
Science humbles man. The reflection into the cosmos is a way to be religious for scientists.
Chapter 8: The imbearable likeness of being
Arthur, after a head injury, thinks his parents are imposters. They decide to fool his brain back into sanity.
Kapgrass delusion.
Rejects psychoanalytic explainations in terms of oedipus complex (son wanting to fuck their mother and vice versa etc), and favors a neuroanatomic approach.
Face recognition areas in temporal lobe and emotional regions in limbic system (e.g. Amygdala).
Arthur was tested for GSR (skin dampness) and this showed he had no emotional reaction to his parents which confimred Dr Rama speculation. In other situations Arthur had normal emotional life (i.e. his amygdala wasn't disfunctional).
He recognized his parents on phone, but not upon seeing him. This is because they is a separate wiring to the Amygdala for vision and hearing, the hearing wasn't damaged.
This teaches us that our brains have special emotional reaction by which we recognize the close people to us. There are also vision centers in the Amygdala (e.g. about gazing).
Author speculates that those who think they are dead and rotting might have complete detachment of the Amygdala.
To test Arthur for gaze detection. He was really bad at it. Interestingly, he thought the same model was 3 different people. He duplicated things, including Panama (the country), his hair (thought it a wig) and even himself (thought he was not the real Arthur). This probably tells us that the ability to store memories in the same category needs some glow or signal from the limbic system.
People with amnesia would forget the person and retain the eomtional memory of him. Mirror of Arthur case. People with Ferguli syndrome think that all people are a certain person or group of people impersonating them, this may be due to excessive connections to the Amygdala.
The case of Arthur calls into question the axiomatic assertion that we are a one unified self that endures through space and time.
Chapter 9: God and the limbic system
Michael Persinger and the God helmet which stimulates the temporal lobe.
Religion as giving solace and meaning to life.
The limbic system. Named by French neurologist Bruka. Epilepsy there as causing religious experiences. Temporal lobe personality. See cosmic significance in everything and write many notes on that (hypergraphia).
Paul, a textbook case of temporal lobe seizures causing religious experience delusions.
Makes speculations on evolutionary psychology. Endorses it, but warns against taking it too far. Makes a speculation on the natural origin of religion.
Author chickens from saying this is evidence against God, saying it could also be used as evidence for God (he doesn't endorse either), for if we say this is an illusion then are colors an illusion too? [Yes they are an illusion created in our brain as representation for wave lengths, incidentally the author has mentioned previously that pain is an illusion.]
GSR of religious people show they have inhabced reaction to religious things and diminshed one for other things, especially sexuality. If we removed the temporal lobe from these patients would they become atheists/agnostics? that is yet to be tested.
Theory of evolution between Darwin and Wallace. Wallace's wondering about why our brains seem to posses capabilities which we do not need for survival (such as math, music etc), this is used to argue for a role for God in making human nature [will he reply to this nonsense?]
Rejects general intelligence explainations. Explains how some genius traits are not associated with general intelligence. Savant syndrome patients as an example.
Left Angular Gyrus has a role in math and computation. Right angular gyrus and art skills.
Brain large size as a side effect of evolving for other purposes. Creativity is what makes us human.
Chapter 10: The woman who died laughing
25 year old man involuntarily laughing out loud at his mother funeral. Continued for several hours. Died 2 days later due ti subarachnoid hemorrhage due to an aneurysm. A lady with same laughing fit to death. A girl whose brain was stimulated during surgery laughed out of control
Laughter and its function. Endorses evolutionary psychology while still describing it as controversial and warning against going too far with explainations (e.g. trying to explain cooking with genes) or adoping gene-determinism vs environmental-determinism dicotomy. Differentiatimg between fact and fiction is very hard in this field as many of the ideas there are unprovable.
*Maximum limit of Goodreads reviews reached!*