In the tradition of Hayao Miyazaki, Uroboros is the epic tail of six young rats of the Land of U in the Time-When-the-Dragon-Open-Its-Eyes. For the denizens of U, the Old Myth has become just another old tail. They have forgotten Creatura, the billion-world-galaxy mother, who invited them into Time, where all things are 'back-words', and they who were called 'star' became... 'rats.' In the Spring of the Year of the Big Blue Fish, two separate journeys begin. Peyo of Yham sets out with his friends Yao and Genji on a bark canoe down the River Fluvinus to find TuTu, the Ra-Tul of Glomber Woods. At the same time, Chloe of Zham sets out with her siblings and geriatric mentor, Dolma, for the dangerous passage across the O-po-po Ice Plains. The adventure turns out to be much bigger than they imagined, changing the lives of all the rats of U, who are about to realize that they live in the time of Myth... and that the world is the Myth... and the Myth is alive!