I'm going to start this review by noting that I am a malaria researcher, myself, and thus am already familiar with much of the material Shah presented in this book. This, of course, affects the way I read the book and my perception of it.
My first gripe with the book is that, to me, the story seemed to be set up in a strange way. The author seems to have broken the book up into a short discussion of the parasite (Plasmodium species), a moderate length discussion on the host (humans, in this case), and a lengthy discussion on the vector (mosquito, Anopheles species). While it is important to understand the roles of all three species in understanding malaria's history and continued prevalence, the way this is done seems to skip out on things in the early chapters without mentioning that they will be discussed later, and then talk about various things in later chapters without tying back to things that were discussed earlier. Perhaps this is evident to me already coming in with a background in the subject, but would not be as evident to those who are unfamiliar with malaria research.
My other issue with the book is that the author, who is a journalist, not a scientist, is clearly trying to tell a story rather than simply presenting the facts (which, frankly, would not be all that interesting and is what we have scientific journals for). As a result, however, there is sometimes a slant to the story, and it feels that we're not getting the whole picture. Also, the sarcastic tone that seems to be present here and there makes it difficult for me to take the author seriously.
Also, the author does point this out, but I think the point is not belabored well enough: MALARIA EXIST OUTSIDE OF AFRICA, TOO. Papua New Guinea has one of the highest malaria rates in the world and is mentioned roughly twice in this book? But this is not an issue strictly defined to this book—much of it has to do with all of the malaria eradication and elimination programs that seem to forget that when we talk about the developing world and infectious disease, we don't just mean Africa.
That being said, this book is absolutely full of fascinating information. If you have an interest in malaria, infectious disease, epidemiology, public health, human history, or whatever, certainly read this book. It's relatively well written and the information is pretty accurate and up to date. You will definitely learn something (or many things!) about malaria.