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“How can a three-pound mass of jelly that you can hold in your palm imagine angels, contemplate the meaning of infinity, and even question its own place in the cosmos? Especially awe inspiring is the fact that any single brain, including yours, is made up of atoms that were forged in the hearts of countless, far-flung stars billions of years ago. These particles drifted for eons and light-years until gravity and change brought them together here, now. These atoms now form a conglomerate- your brain- that can not only ponder the very stars that gave it birth but can also think about its own ability to think and wonder about its own ability to wonder. With the arrival of humans, it has been said, the universe has suddenly become conscious of itself. This, truly, it the greatest mystery of all.”
V.S. Ramachandran, The Tell-Tale Brain: A Neuroscientist's Quest for What Makes Us Human
“Indeed, the line between perceiving and hallucinating is not as crisp as we like to think. In a sense, when we look at the world, we are hallucinating all the time. One could almost regard perception as the act of choosing the one hallucination that best fits the incoming data.”
V.S. Ramachandran, The Tell-Tale Brain: A Neuroscientist's Quest for What Makes Us Human
“The human brain, it has been said, is the most complexly organised structure in the universe and to appreciate this you just have to look at some numbers. The brain is made up of one hundred billion nerve cells or "neurons" which is the basic structural and functional units of the nervous system. Each neuron makes something like a thousand to ten thousand contacts with other neurons and these points of contact are called synapses where exchange of information occurs. And based on this information, someone has calculated that the number of possible permutations and combinations of brain activity, in other words the numbers of brain states, exceeds the number of elementary particles in the known universe.”
V.S. Ramachandran
“Self-awareness is a trait that not only makes us human but also paradoxically makes us want to be more than merely human. As I said in my BBC Reith Lectures, “Science tells us we are merely beasts, but we don’t feel like that. We feel like angels trapped inside the bodies of beasts, forever craving transcendence”
V.S. Ramachandran, The Tell-Tale Brain: A Neuroscientist's Quest for What Makes Us Human
“The common denominator of all jokes is a path of expectation that is diverted by an unexpected twist necessitating a complete reinterpretation of all the previous facts — the punch-line…Reinterpretation alone is insufficient. The new model must be inconsequential. For example, a portly gentleman walking toward his car slips on a banana peel and falls. If he breaks his head and blood spills out, obviously you are not going to laugh. You are going to rush to the telephone and call an ambulance. But if he simply wipes off the goo from his face, looks around him, and then gets up, you start laughing. The reason is, I suggest, because now you know it’s inconsequential, no real harm has been done. I would argue that laughter is nature’s way of signaling that "it’s a false alarm." Why is this useful from an evolutionary standpoint? I suggest that the rhythmic staccato sound of laughter evolved to inform our kin who share our genes; don’t waste your precious resources on this situation; it’s a false alarm. Laughter is nature’s OK signal.”
V.S. Ramachandran, A Brief Tour of Human Consciousness: From Impostor Poodles to Purple Numbers
“He had the arrogance of the believer, but none of the humility of the deeply religious.”
V.S. Ramachandran
“It is difficult to overstate the importance of understanding mirror neurons and their function. They may well be central to social learning, imitation, and the cultural transmission of skills and attitudes—perhaps even of the pressed-together sound clusters we call words. By hyperdeveloping the mirror-neuron system, evolution in effect turned culture into the new genome. Armed with culture, humans could adapt to hostile new environments and figure out how to exploit formerly inaccessible or poisonous food sources in just one or two generations—instead of the hundreds or thousands of generations such adaptations would have taken to accomplish through genetic evolution.

Thus culture became a significant new source of evolutionary pressure, which helped select brains that had even better mirror-neuron systems and the imitative learning associated with them. The result was one of the many self-amplifying snowball effects that culminated in Homo sapiens, the ape that looked into its own mind and saw the whole cosmos reflected inside.”
V.S. Ramachandran, The Tell-Tale Brain: A Neuroscientist's Quest for What Makes Us Human
“Even though its common knowledge these days, it never ceases to amaze me that all the richness of our mental life - all our feelings, our emotions, our thoughts, our ambitions, our love life, our religious sentiments and even what each of us regards us his own intimate private self - is simply the activity of these little specks of jelly in your head, in your brain. There is nothing else.”
V.S. Ramachandran, A Brief Tour of Human Consciousness: From Impostor Poodles to Purple Numbers
“I learned an important lesson: Never take the obvious for granted. Once upon a time, it was so obvious that a four-pound rock would plummet earthward twice as fast as a two-pound rock that no one ever bothered to test it. That is, until Galileo Galilei came along and took ten minutes to perform an elegantly simple experiment that yielded a counterintuitive result and changed the course of history.”
V.S. Ramachandran, The Tell-Tale Brain: A Neuroscientist's Quest for What Makes Us Human
“science should be question driven, not methodology driven.”
V.S. Ramachandran, The Tell-Tale Brain: A Neuroscientist's Quest for What Makes Us Human
“Any ape can reach for a banana, but only humans can reach for the stars.”
V.S. Ramachandran, The Tell-Tale Brain: A Neuroscientist's Quest for What Makes Us Human
“Yet as human beings we have to accept-with humility-that the question of ultimate origins will always remain with us, no matter how deeply we understand the brain and the cosmos that it creates.”
V.S. Ramachandran, The Tell-Tale Brain: A Neuroscientist's Quest for What Makes Us Human
“Science tells us we are merely beasts, but we don’t feel like that. We feel like angels trapped inside the bodies of beasts, forever craving transcendence.”
V.S. Ramachandran, The Tell-Tale Brain: A Neuroscientist's Quest for What Makes Us Human
“What do we mean by "knowledge" or "understanding"? And how do billions of neurons achieve them? These are complete mysteries. Admittedly, cognitive neuroscientists are still very vague about the exact meaning of words like "understand," "think," and indeed the word "meaning" itself.”
V. S. Ramachandran, The Tell-Tale Brain: Unlocking the Mystery of Human Nature
“The purpose of all of this (left hemisphere's way of choosing denial or repression over considering an anomaly) is to impose stability on behavior and to prevent vacillation because indecisiveness doesn't serve any purpose. Any decision, so long as it is probably correct, is better than no decision at all. A perpetually fickle general will never win a war.”
V.S. Ramachandran, Phantoms in the Brain: Probing the Mysteries of the Human Mind
“So here is the greatest irony of all: that the self that almost by definition is entirely private is to significant extent a social construct.”
V.S. Ramachandran, Phantoms in the Brain: Probing the Mysteries of the Human Mind
“I found myself drawn to biology, with all its frustrating yet fascinating complexities. When I was twelve, I remember reading about axolotls, which are basically a species of salamander that has evolved to remain permanently in the aquatic larval stage. They manage to keep their gills (rather than trading them in for lungs, like salamanders or frogs) by shutting down metamorphosis and becoming sexually mature in the water. I was completely flabbergasted when I read that by simply giving these creatures the “metamorphosis hormone” (thyroid extract) you could make the axolotl revert back into the extinct, land-dwelling, gill-less adult ancestor that it had evolved from. You could go back in time, resurrecting a prehistoric animal that no longer exists anywhere on Earth. I also knew that for some mysterious reason adult salamanders don’t regenerate amputated legs but the tadpoles do. My curiosity took me one step further, to the question of whether an axolotl—which is, after all, an “adult tadpole”—would retain its ability to regenerate a lost leg just as a modern frog tadpole does. And how many other axolotl-like beings exist on Earth, I wondered, that could be restored to their ancestral forms by simply giving them hormones? Could humans—who are after all apes that have evolved to retain many juvenile qualities—be made to revert to an ancestral form, perhaps something resembling Homo erectus, using the appropriate cocktail of hormones? My mind reeled out a stream of questions and speculations, and I was hooked on biology forever. I found mysteries and possibilities everywhere.”
V.S. Ramachandran, The Tell-Tale Brain: A Neuroscientist's Quest for What Makes Us Human
“One of the first things we teach medical students is to listen to the patient by taking a careful medical history. Ninety percent of the time, you can arrive at an uncannily accurate diagnosis by paying close attention, using physical examination and sophisticated lab test to confirm your hunch (and to increase the bill to the insurance company).”
V.S. Ramachandran, The Tell-Tale Brain: A Neuroscientist's Quest for What Makes Us Human
“The law of perceptual problem solving, or peekaboo, should now make more sense. It may have evolved to ensure that the search for visual solutions is inherently pleasurable rather than frustrating, so that you don’t give up too easily.”
V.S. Ramachandran, The Tell-Tale Brain: A Neuroscientist's Quest for What Makes Us Human
“All good science emerges from an imaginative conception of what might be true.”
V.S. Ramachandran, The Tell-Tale Brain: A Neuroscientist's Quest for What Makes Us Human
“No engineer would have dreamed of such an inelegant solution, which goes to illustrate the opportunistic nature of evolution. (As Francis Crick once said, ‘God is a hacker, not an engineer.’)”
V.S. Ramachandran, The Tell: Tale Brain-Unlocking the Mystry of Human Nature
“How does language interact with thought? Does language enable us to think, or does thinking enable us to talk?”
V.S. Ramachandran, The Tell-Tale Brain: A Neuroscientist's Quest for What Makes Us Human
“Homogeneity breeds weakness: theoretical blind spots, stale paradigms, an echo-chamber mentality, and cults of personality.”
V.S. Ramachandran, The Tell-Tale Brain: A Neuroscientist's Quest for What Makes Us Human
“Indeed, the line between perceiving and hallucinating is not as crisp as we like to think. In a sense, when we look at the world, we are hallucinating all the time. One could almost regard perception as the act of choosing the one hallucination that best fits the incoming data, which is often fragmentary and fleeting. Both hallucinations and real perceptions emerge from the same set of processes. The crucial difference is that when we are perceiving, the stability of external objects and events helps anchor them. When we hallucinate, as when we dream or float in a sensory deprivation tank, objects and events wander off in any direction.”
V.S. Ramachandran, The Tell: Tale Brain-Unlocking the Mystry of Human Nature
“It’s as if each of us is hallucinating all the time and what we call perception involves merely selecting the one hallucination that best matches the current input.”
V.S. Ramachandran, The Tell-Tale Brain: Unlocking the Mystery of Human Nature
“The real drive to understand the self, though, comes not from the need to develop treatments, but from a more deep-seated urge that we all share: the desire to understand ourselves. Once self-awareness emerged through evolution, it was inevitable that an organism would ask, ― Who am I? Across vast stretches of inhospitable space and immeasurable time, there suddenly emerged a person called Me or I. Where does this person come from? Why here? Why now? You, who are made of star-dust, are now standing on a cliff, gazing at the starlit sky pondering your own origins and your place in the cosmos.”
V.S. Ramachandran, The Tell-Tale Brain: A Neuroscientist's Quest for What Makes Us Human
“Indeed, one could go so far as to say that humor helps as an effective antidote against a useless struggle against the ultimate danger: the ever-present fear of death in self-conscious beings like us.”
V.S. Ramachandran, The Tell-Tale Brain: A Neuroscientist's Quest for What Makes Us Human
“Getting trapped in narrow cul-de-sac specializations and “clubs” whose membership is open only to those who congratulate and fund each other is an occupational hazard in modern science”
V.S. Ramachandran, The Tell-Tale Brain: A Neuroscientist's Quest for What Makes Us Human
“How does language interact with thought? Does language enable us to think, or does thinking enable us to talk? Can we think in a sophisticated manner without silent internal speech? And lastly, how did this extraordinarily complex, multicomponent system originally come into existence in our hominin ancestors?”
V.S. Ramachandran, The Tell-Tale Brain: A Neuroscientist's Quest for What Makes Us Human
“Despite all their surface diversity, most jokes and funny incidents have the following logical structure: Typically you lead the listener along a garden path of expectation, slowly building up tension. At the very end, you introduce an unexpected twist that entails a complete reinterpretation of all the preceding data, and moreover, it's critical that the new interpretation, though wholly unexpected, makes as much "sense" of the entire set of facts as did the originally "expected" interpretation.
In this regard, jokes have much in common with scientific creativity, with what Thomas Kuhn calls a "paradigm shift" in response to a single "anomaly." (It's probably not coincidence that many of the most creative scientists have a great sense of humor.) Of course, the anomaly in the joke is the traditional punch line and the joke is "funny" only if the listener gets the punch line by seeing in a flash of insight how a completely new interpretation of the same set of facts can incorporate the anomalous ending.
The longer and more tortuous the garden path of expectation, the "funnier" the punch line when finally delivered.”
V.S. Ramachandran

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