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“Eliminate simple carbohydrates—sugar, candy, cookies, muffins, cakes, breads, pasta, crackers, white potatoes, grains, soft drinks (both regular and diet, since artificial sweeteners disrupt your gut health), fruit juices, alcohol, processed foods, and anything with high-fructose corn syrup. As you limit your intake of simple carbohydrates, you’ll be surprised to find that you fairly quickly lose your desire for sweet-tasting food.”
Dale E. Bredesen, The End of Alzheimer's Program: The First Protocol to Enhance Cognition and Reverse Decline at Any Age
“If your Cyrex Array 2 is positive or you have food sensitivities, bloating, constipation, or loose stools, you likely have leaky gut, meaning that the integrity of your gut lining has been compromised. Healing your gut reduces systemic inflammation, improves nutrient absorption, enhances immune responses, and supports an optimal microbiome, thus increasing the products of the microbiome, such as some hormones and neurotransmitters.”
Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline
“It is a good idea to take an occasional melatonin “holiday” (for example, skip one night per week). This allows your body to continue to make its own.”
Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline
“when something is ever present, you stop responding to it. This insulin resistance contributes not only to type 2 diabetes, fatty liver, and metabolic syndrome, but also to Alzheimer’s disease.”
Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline
“Eating fiber is a powerful way to reduce blood sugar—the carbohydrate absorption is curtailed and the optimal microbiome is supported.”
Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline
“During this struggle I could not help thinking about the birth of functional medicine, in which a physician determines the root causes of illnesses and treats all contributing factors. Drs. Jeffrey Bland, David Jones, David Perlmutter, Mark Hyman—starting about two decades ago, they began treating complex chronic problems like type 2 diabetes, lupus, and obesity with unprecedented success. Yet medical schools had virtually no interest in teaching about this approach. As the pioneers of functional medicine discovered, you know you are doing something that is paradigm changing when you are doing it right in front of everyone but no one can see it.”
Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline
“If your evaluation identified sleep apnea, it is critical to treat this.”
Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline
“One of the most important contributors to Alzheimer’s disease is inflammation, and one of the most common ways to create systemic inflammation is a leaky gut.”
Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline
“Make foods with a glycemic index lower than 35 the bulk of your diet.”
Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline
“your Cyrex Array 2 is positive or you have food sensitivities, bloating, constipation, or loose stools, you likely have leaky gut, meaning that the integrity of your gut lining has been compromised.”
Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline
“You need your stomach acid to allow your enzymes to break down your food so that it can be absorbed properly—along with zinc, magnesium, vitamin B12, and other essentials”
Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline
“The 12/3 part of Ketoflex 12/3 refers to fasting times.”
Dale E. Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline
“Success is how high you bounce when you hit bottom. —GEORGE S. PATTON JULIE”
Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline
“GOAL: vitamin B12 = 500–1500 pg/ml; folate = 10–25 ng/ml; vitamin B6 = 60–100 mcg/L.”
Dale E. Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline
“when evaluating thyroid status, you can get a good analysis of the actual thyroid function by evaluating basal body temperature in the morning, or using Thyroflex to measure the timing of one of your reflexes. If your temperature is not at least 97.8 degrees Fahrenheit (36.5 degrees Celsius), then your thyroid function is likely to be suboptimal.”
Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline
“In men, low progesterone levels are often associated with low testosterone, since progesterone is a precursor for testosterone. Since low testosterone is also a risk factor for cognitive decline, men should optimize their testosterone levels in coordination with their physician.”
Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline
“Avoid fruit juices in favor of whole fruits (which include the fiber).”
Dale E. Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline
“low rather than high cholesterol is associated with cognitive decline. When total cholesterol falls below 150, you are more likely to suffer brain atrophy—shrinking. Cholesterol is a key part of cell membranes, including those of brain”
Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline
“Another good indicator of metabolic status is your waistline: it should be less than 35 inches for females or 40 inches for males.”
Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline
“Stress also increases a number of risk factors for cognitive decline and Alzheimer’s disease, including blood glucose levels, body fat, risk for obesity, carbohydrate craving, leaky gut and the resulting inflammation, permeability of the blood-brain barrier, calcium release and hyperstimulation of neurons, and the risk of cardiovascular disease.”
Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline
“Include good fats in your diet, such as those from avocados, nuts, seeds, olive oil, and MCT oil.”
Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline
“a workaround to restore your nasal microbiome is to swab your nose with kimchi juice.”
Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline
“Insulin sensitivity is affected by zinc levels, so if yours is below 100, try 20 mg to 50 mg of zinc picolinate daily, then recheck your glucose after two months. High hemoglobin A1c reflects poor glucose control, which is affected by low magnesium. If your RBC magnesium is less than 5.2, try magnesium glycinate (500 mg per day) or magnesium threonate (2 g per day). Cinnamon turns out to be a wonderful way to improve glycemic control. You need only ¼ teaspoon each day, sprinkled on food, or you can easily take it as 1-gram capsules. Cinnamon also improves lipid profiles in people with type 2 diabetes.3 Alpha-lipoic acid is an antioxidant. Most people use 60 mg to 100 mg daily. Chromium picolinate also lowers blood glucose, and 400 micrograms to 1 milligram daily is the typical dosage. Berberine lowers blood glucose, and is usually taken at 300 to 500 milligrams three times per day. Your physician may also prescribe metformin to reduce blood glucose.”
Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline
“The BrainHQ group has optimized the programs so you need only 10 or 20 minutes per day, five days per week, to see improvements. Alternatively, you can use a schedule of 30 minutes, three times per week. Start with Hawkeye and Double Decision, and you can add memory and other processing speed games, but don’t get discouraged! The programs are set up to continue to challenge you, so as soon as you start doing well, they become more difficult.”
Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline
“melatonin at bedtime—anywhere from 0.3 mg to 0.5 mg. If you need more than this, it’s fine to take up to 20 mg.”
Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline
“Meat is a condiment, not the main course.”
Dale E. Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline
“gluten can damage the gut lining in most of us, leading to leaky gut and chronic inflammation, among other problems. As for dairy, many of us can “handle” the inflammation it causes (and, after all, what is better than pizza?).”
Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline
“The back of the eye, or retina, is an extension of the brain and therefore reflects what is ongoing in there. That makes evaluating the retina for amyloid plaques a highly promising approach.”
Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline

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