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“If there is one central intellectual reality at the end of the twentieth century, it is that the biological approach to psychiatry--treating mental illness as a genetically influenced disorder of brain chemistry--has been a smashing success. Freud's ideas, which dominated the history of psychiatry for the past half century, are now vanishing like the last snows of winter.”
Edward Shorter, A History of Psychiatry: From the Era of the Asylum to the Age of Prozac
“In 1833, chemists isolated the alkaloid hyoscyamine from henbane and the Merck company in Darmstadt began marketing it for various nonpsychiatric indications. Finally in 1868, the Viennese pharmacologist Karl Schroff established that hyoscyamus acted as a sedative and hypnotic.”
Edward Shorter, A History of Psychiatry: From the Era of the Asylum to the Age of Prozac
“What has typically happened over the past two hundred years is the slow emergence of a concept as a gradual, evolutionary exercise in collective wisdom: People see something in their patients that hadn’t occurred to them before; they write about it; others start seeing the same thing – for example, that some patients seem to be driven by a kind of furious rage – and slowly the concept emerges. But what comes out of this collective filtering is often a powerful notion, because lots of thoughtful people have endorsed it. (..) in the absence of actual science, the disease designers of the 1970s who produced DSM- 3 in 1980 settled for “consensus”: If a group of influential persons sitting about a table could agree that a disease existed, then it existed.”
Edward Shorter, What Psychiatry Left Out of the DSM-5: Historical Mental Disorders Today

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A History of Psychiatry: From the Era of the Asylum to the Age of Prozac A History of Psychiatry
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How Everyone Became Depressed: The Rise and Fall of the Nervous Breakdown How Everyone Became Depressed
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Before Prozac: The Troubled History of Mood Disorders in Psychiatry Before Prozac
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Shock Therapy: A History of Electroconvulsive Treatment in Mental Illness Shock Therapy
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