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“Glucose molecules are driven into cells in the presence of insulin. This is independent of the carbohydrate source (simple or complex, table sugar or broccoli). As dictated by the metabolic demands of the body at that instant, glucose is either utilized for ATP production or stored as glycogen or converted to fat. Eat an ice cream sundae and lay on the couch, for example. There is no immediate demand for the consumed glucose and all the surplus is therefore converted to fatty acids and stored as fat. This is why I am an advocate of short walks after a meal; just the opposite occurs. Create a demand and the body will utilize the consumed glucose for energy production, fueling your leg muscles! This equates to less circulating glucose and less AGE formation, in essence conferring protection to the endothelial lining of the blood vessels.”
Brett Osborn, Get Serious
“You are a reservoir of biochemical processes, an unbelievably complex machine, albeit with a high degree of predictability. Our bodies, for the most part, act according to a set of rules that evolved over eons as an adaptive response to environmental pressures. Health is attained through sound biochemistry. The absence of health (disease) is biochemical dysregulation. In other words, we start off healthy and we screw it up! A”
Brett Osborn, Get Serious
“Does it surprise you that Alzheimer’s disease is referred to as “type III diabetes” by virtue of their similar pathophysiology? It shouldn’t. Nor should the preventable nature of these diseases. So”
Brett Osborn, Get Serious
“This is not a race. There are no races when weights are involved (unless you are racing to a local ER having been injured as a result of stupidity).”
Brett Osborn, Get Serious
“As you learn to write with your left hand, for example, you learn to properly execute a squat. The process of learning literally rewires the brain. That’s why it takes time. You cannot master the squat overnight. Why? The brain has to change. Neuronal connections or “synapses” are formed through very complex biophysical mechanisms under the influence of growth factors such as NGF (nerve growth factor) and BDNF (brain-derived nerve factor).”
Brett Osborn, Get Serious
“Your brain is “plastic” even during your later years. You have within you the capability of altering your brain which will secondarily alter your body, at any age.”
Brett Osborn, Get Serious
“Yes. There are a variety of reasons that we as humans age, one of which is oxidant stress from free radical formation. Known as the Free Radical Theory of Aging, this explanation was first proposed by Denham Harman in the 1950s. Other theories include unchecked inflammation, glycation, cell membrane and DNA damage. Interestingly, they are interrelated as I will explain. Every cell in our body requires energy for a variety of processes. The production of such cellular energy or ATP (adenosine triphosphate) is occurring at the molecular level, unbeknownst to you, billions of times per second, in cellular structures known as mitochondria. Through a complex series of chemical reactions, electrons are ultimately transferred to oxygen, driving the formation of ATP molecules. No oxygen, no electron receptor, death ensues. (Note: Cyanide poisons this so-called “electron transport chain” often times resulting in death.) This process of ATP generation is imperfect.”
Brett Osborn, Get Serious
“Men with fasting glucose over 85 mg/dL had a 40 percent increased risk of death from cardiovascular disease.”
Brett Osborn, Get Serious
“I don’t believe in diets. In fact, there is no such thing as a diet. Well-fit individuals were around eons before the word “diet” even existed.”
Brett Osborn, Get Serious

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