“Griffiths’s paper and its reception served to reinforce an important distinction between the so-called classic psychedelics—psilocybin, LSD, DMT, and mescaline—and the more common drugs of abuse, with their demonstrated toxicity and potential for addiction. The American drug research establishment, such as it is, had signaled in the pages of one of its leading journals that these psychedelic drugs deserved to be treated very differently and had demonstrated, in the words of one commentator, “that, when used appropriately, these compounds can produce remarkable, possibly beneficial, effects that certainly deserve further study.”